EP
A compound of formula (III): or a salt, solvate and chemically protected form thereof, wherein: R 5 is an optionally substituted C 5-20 aryl or C 4-20 alkyl group; L′ is a single bond, —O— or —C(═O)—; A is selected from the group consisting of: formula (i) (ii) (iii) wherein X and Y are selected from the group consisting of: O and CR 3 ; S and CR 3 ; NH and CR 3 ; NH and N; O and N; S and N; N and S; and N and O, and where the dotted lines indicate a double bond in the appropriate location, and where Q is either N or CH; D is selected from: formula (i) (ii) (iii) (iv) (v) (vii) (viii) (ix) B is selected from the group consisting of: formula (A) (B) where R P6 is selected from fluoro and chloro; and R 2 is either: (i) —CO 2 H; (ii) —CONH 2 ; (iii) —CH 2 —OH; or (iv) tetrazol-5-yl.
1. A compound of formula (III):
or a salt or an ester thereof, wherein:
R 5 is phenyl or substituted phenyl wherein each substitution is independently selected from the group consisting of C 1-4 alkoxy, C 1-4 alkyl, halo, acyl, and amino;
L′ is a single bond, —O— or —C(═O)—;
A is selected from the group consisting of:
D is selected from:
B is selected from the group consisting of:
where R P6 is selected from fluoro and chloro;
where R P4 is H and R P3 is —CH═CH—R 2 ;
n is 0 or 1;
R N is H or optionally substituted C 1-4 alkyl; and
R 2 is either:
(i) —CO 2 H;
(ii) —CONH 2 ;
(iii) —CH 2 —OH; or
(iv) tetrazol-5-yl.
2. A compound according to claim 1 , wherein R 5 is phenyl.
3. A compound according to claim 1 , wherein L′ is a single bond.
4. A compound according to claim 1 , wherein D is
5. A compound according to claim 4 , wherein R N is H.
6. A compound according to claim 1 , wherein B is:
7. A compound according to claim 1 , wherein R 2 is —CO 2 H.
8. A compound according to claim 1 , wherein n is 0.
9. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier or diluent.
10. The compound according to claim 6 wherein L′ is a single bond.
11. The compound according to claim 10 where D is
and R N is H.
12. The compound according to claim 11 wherein n is 0.
13. The compound according to claim 11 wherein R 2 is —CO 2 H.
14. The compound according to claim 13 wherein R 5 is phenyl or substitued phenyl wherein each substitution is independently selected from the group consisting of C 1-4 alkoxy, C 1-4 alky, halo, acyl, and amino.
15. The compound according to claim 13 wherein R 5 is phenyl or substituted phenyl wherein each substitution is independently selected from the group consisting of —OCH 3 , —OCF 3 , —OCH 2 CH 3 , —OCHF 2 , —CH 3 , —CF 3 , —CH(CH 3 ) 2 , Cl, and F.
16. The compound according to claim 15 wherein n is 0.
17. The compound according to claim 16 wherein R 5 is phenyl.
18. The compound according to claim 1 wherein R 5 is phenyl or substituted phenyl wherein each substitution is independently selected from the group consisting of —OCH 3 , —OCF 3 , —OCH 2 CH 3 , —OCHF 2 , —CH 3 , —CF 3 , —CH(CH 3 ) 2 , Cl, and F.
19. The compound according to claim 18 wherein R 2 is —CO 2 H.
20. The compound according to claim 19 wherein n is 0.
21. The compound according to claim 20 wherein R 5 is phenyl.