Pyridine derivatives and their use in the treatment of psychotic disorders
There are provided according to the invention novel compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein all variables are defined herein. Also provided are pharmaceutical compositions containing the same and methods for their use in therapy.
1. A compound of formula
or a pharmaceutically acceptable salt thereof.
2. 2-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide.
3. 2-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide hydrochloride.
4. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier or excipient.
5. A pharmaceutical composition comprising a compound according to claim 2 and a pharmaceutically acceptable carrier or excipient.
6. A pharmaceutical composition comprising a compound according to claim 3 and a pharmaceutically acceptable carrier or excipient.
7. A method of treatment of a Depressive Disorder or schizophrenia which comprises administering to a human in need thereof an effective amount of a compound according to claim 1 .
8. A method of treatment of a Depressive Disorder or schizophrenia which comprises administering to a human in need thereof an effective amount of a compound according to claim 2 .
9. A method of treatment of a Major Depressive Disorder which comprises administering to a human in need thereof an effective amount of a compound according to claim 1 .
10. A method of treatment of a Major Depressive Disorder which comprises administering to a human in need thereof an effective amount of a compound according to claim 2 .
11. A method of treatment of schizophrenia which comprises administering to a human in need thereof an effective amount of a compound according to claim 1 .
12. A method of treatment of schizophrenia which comprises administering to a human in need thereof an effective amount of a compound according to claim 2 .