Compounds with anti-cancer activity

1. A compound to treat cell proliferation disorders having the formula of Structure (II):

wherein

R 1 and R 2 are independently chosen from alkyl, substituted alkyl, and optionally substituted alkoxy, wherein at least one of R 1 and R 2 is methyl, and where R 1 and R 2 can be part of a cyclic alkylene chain that forms a fused ring structure;

X is NR 3 ;

R 3 is H, alkyl, or acyl;

A is N or CH;

B is CR 8 ;

R 6 is selected from H, alkyl, substituted alkyl, and halogen,

R 7 is selected from H, alkyl, substituted alkyl, halogen, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkoxy, optionally substituted aryloxy, cyano, optionally substituted alkylthio, optionally substituted alkylsufinyl, optionally substituted alkylsulfonyl, optionally substituted arylthio, optionally substituted acyl, optionally substituted amino, carboxyl, optionally substituted alkoxycarbonyl, optionally substituted carbamoyl, and wherein R 6 and R 7 can form an aryl group forming a fused ring structure when each of R 6 and R 7 is alkyl;

R 8 is selected from H, alkyl, substituted alkyl, halogen, and

R 9 is selected from H, alkyl, substituted alkyl, halogen, optionally substituted aryl, and cyano, wherein R 8 and R 9 can form one or more optionally substituted aryl groups forming a fused ring structure when each of R 8 and R 9 is alkyl or substituted alkyl

and wherein at least one of R 6 , R 7 ,R 8 , and R 9 is halogen selected from Br or Cl, or substituted alkyl substituted with halogen selected from Br, Cl, or F;

or a salt thereof.

2. The compound of claim 1 , wherein one of R 1 and R 2 is methyl, and the other of R 1 and R 2 is alkyl or alkyl substituted with alkoxy, hydroxy, carboxy, or alkoxycarbonyl.

3. The compound of claim 1 , wherein R 3 is H, methyl, or acyl.

4. The compound of claim 2 , wherein one of R 1 and R 2 is methyl, and the other of R 1 and R 2 is alkyl or alkyl substituted with alkoxy, hydroxy, carboxy, alkoxycarbonyl, wherein alkoxy includes cyclic alkoxy, and R 6 is H, R 7 is H, R 8 is CF 3 , and R 9 is Cl.

5. A compound to treat cell proliferation disorders having the formula of Structure (II):

wherein

R 1 and R 2 are independently chosen from alkyl, substituted alkyl, and optionally substituted alkoxy, optionally substituted alkylthio, halogen, optionally substituted aryl, optionally substituted aryloxy, optionally substituted arylthio, or H, where R 1 and R 2 can be part of a cyclic alkylene chain that forms a fused ring structure;

X is NR 3 ;

R 3 is H, alkyl, or acyl;

A is N or CH;

B is CR 8 or N;

R 6 , R 7 , R 8 , and R 9 are independently chosen from H, alkyl, substituted alkyl, halogen, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkoxy, optionally substituted aryloxy, cyano, optionally substituted alkylthio, optionally substituted alkylsufinyl, optionally substituted alkylsulfonyl, optionally substituted arylthio, optionally substituted acyl, optionally substituted amino, carboxyl, optionally substituted alkoxycarbonyl, optionally substituted carbamoyl, wherein R 6 and R 7 , or R 7 and R 8 , or R 8 and R 9 can be part of a cyclic alkylene group forming a fused ring structure;

wherein the compound is selected from the group consisting of

tert-butyl 3-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl) propanoate (S01860);

ethyl 3-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl) propanoate (S01861),

3,4-dimethyl-1-[(4,7,8-trichloro(2-quinolyl))amino]azoline-2,5-dione (S01078),

1-[(8-bromo-4-chloro(2-quinolyl))amino]-3,4-dimethylazoline-2,5-dione (S01247),

tert-butyl 4-({2-[(3,4-dimethyl-2,5-dioxoazolinyl)amino]-7-bromo-4-quinolyl}methyl) piperazinecarboxylate (S01589),

methyl 3-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)propanoate (S01648),

3-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)-N-methoxy-N-methylpropanamide (S01796),

1-{[7-bromo-4-({4-[(2-methoxyphenyl)carbonyl]piperazinyl}methyl)(2-quinolyl)]amino}-3,4-dimethylazoline-2,5-dione (S01879),

1-{[3-bromo-6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-3,4-dimethylazoline-2,5-dione (S01981),

1-{[6-chloro-3-(trifluoromethyl)(2-pyridyl)]amino}-3,4-dimethylazoline-2,5-dione (S00109),

1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]methylamino}-3,4-dimethylazoline-2,5-dione (S00170),

1-{[6-bromo-5-(trifluoromethyl)(2-pyridyl)]methylamino}-3,4-dimethylazoline-2,5-dione (S01007),

1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-3-(3-methylbutyl)azoline-2,5-dione (S01554),

1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-3-(methoxymethyl)-4-methylazoline-2,5-dione (S01599),

1-{[7,8-dichloro-4-(trifluoromethyl)(2-quinolyl)]amino}-3,4-dimethylazoline-2,5-dione (S01455),

3-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)-N,N-diethylpropanamide (S01711),

diethyl 2-[(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)methyl]propane-1,3-dioate (S01712),

N-(tert-butyl)-3-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)propanamide (S01758),

1-{[7-bromo-4-({4-[(3-methoxyphenyl)carbonyl]piperazinyl}methyl)(2-quinolyl)]amino}-3,4-dimethylazoline-2,5-dione (S01925),

1-{[6-bromo-5-(trifluoromethyl)(2-pyridyl)]amino}-3,4-dimethylazoline-2,5-dione (S00994),

1-[(4,8-dichloro(2-quinolyl))amino]-3,4-dimethylazoline-2,5-dione (S01005),

3,4-dimethyl-1-{[6-phenyl-5-(trifluoromethyl)(2-pyridyl)]amino}azoline-2,5-dione (S01266),

1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-3-(hydroxymethyl)-4-methylazoline-2,5-dione (S01470),

N-(3,4-dimethyl-2,5-dioxoazolinyl)-N-[6-chloro-5-(trifluoromethyl)(2-pyridyl)]acetamide (S01473),

1-{[7-bromo-4-({4-[(2-chlorophenyl)carbonyl]piperazinyl}methyl)(2-quinolyl)]amino}-3,4-dimethylazoline-2,5-dione (S01878),

3-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)-N-methylpropanamide (S01883),

1-[(8-chloro(2-quinolyl))amino]-3,4-dimethylazoline-2,5-dione (S00585),

3,4-dimethyl-1-[(3,4,5-trichlorophenyl)amino]azoline-2,5-dione (S00832),

3,4-dimethyl-1-{[4-(trifluoromethyl)(2-quinolyl)]amino}azoline-2,5-dione (S00873),

1-[(7-bromo-4-chloro(2-quinolyl))amino]-3,4-dimethylazoline-2,5-dione (S01311),

1-{[6-(3-chloro-4-fluorophenyl)-5-(trifluoromethyl)(2-pyridyl)]amino}-(3,4-dimethylmethylazoline-2,5-dione (S01313),

3,4-dimethyl-1-{[6-(2-methylpropyl)-5-(trifluoromethyl)(2-pyridyl)]amino}azoline-2,5-dione (S01457),

1-{[6-chloro-4-(trifluoromethyl)(2-pyridyl)]amino}-3,4-dimethylazoline-2,5-dione (S01737),

Methyl 3-(1-{[4-({4-[(tert-butyl)oxycarbonyl]piperazinyl}methyl)-7-bromo(2-quinolyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)propanoate (S01865),

1-({4-[(4-{[4-(dimethylamino)phenyl]carbonyl}piperazinyl)methyl]-7-bromo(2-quinolyl)}amino)-3,4-dimethylazoline-2,5-dione (S01880),

1-[(3-chloroisoquinolyl)amino]-3,4-dimethylazoline-2,5-dione (S01098),

1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-3-ethyl-4-methylazoline-2,5-dione (S01553),

1-{[4-chloro-6-phenyl-5-(trifluoromethyl)(2-pyridyl)]amino}-3,4-dimethylazoline-2,5-dione (S01734),

N-[1-({2-[(3,4-dimethyl-2,5-dioxoazolinyl)amino]-7-bromo(4-quinolyl)}methyl) pyrrolidin-3-yl](tert-butoxy)carboxamide (S01864),

1-{[7-bromo-4-({4-[(4-fluorophenyl)carbonyl]piperazinyl}methyl)(2-quinolyl)]amino}-3,4-dimethylazoline-2,5-dione (S01877),

6-[(3,4-dimethyl-2,5-dioxoazolinyl)amino]-3-(trifluoromethyl)pyridine-2-carbonitrile (S01475),

2-{[6-chloro-5-(trifluoromethyl)-2-pyridyl]amino}-4,5,6,7-tetrahydroisoindole-1,3-dione (S00186),

1-{[4-bromo-3-(trifluoromethyl)phenyl]amino}-3,4-dimethylazoline-2,5-dione (S00516),

1-[(4-chloronaphthyl)amino]-3,4-dimethylazoline-2,5-dione (S00738),

1-[(4-chloro-6-methyl(2-quinolyl))amino]-3,4-dimethylazoline-2,5-dione (S00935),

1-[(4-bromonaphthyl)amino]-3,4-dimethylazoline-2,5-dione (S00942),

1-{[7-bromo-4-(hydroxymethyl)(2-quinolyl)]amino}-3,4-dimethylazoline-2,5-dione (S01037),

{2-[(3,4-dimethyl-2,5-dioxoazolinyl)amino]-7-bromo-4-quinolyl}methyl acetate (S01047),

1-{[8-chloro-4-(4-methoxyphenyl)(2-quinolyl)]amino}-3,4-dimethylazoline-2,5-dione (S01191),

1-[(4-chlorobenzo[h]quinolin-2-yl)amino]-3,4-dimethylazoline-2,5-dione (S01207),

1-[(7-bromo-4-{[4-benzylpiperazinyl]methyl}(2-quinolyl))amino]-3,4-dimethylazoline-2,5-dione (S01268),

1-{[6-(4-chlorophenyl)-5-(trifluoromethyl)(2-pyridyl)]amino}-3,4-dimethylazoline-2,5-dione (S01371),

3,4-dimethyl-1-{[6-(4-methylphenyl)-5-(trifluoromethyl)(2-pyridyl)]amino}azoline-2,5-dione (S01393),

1-{[6-(3-chlorophenyl)-5-(trifluoromethyl)(2-pyridyl)]amino}-3,4-dimethylazoline-2,5-dione (S01474),

1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]methylamino}-3-(methoxymethyl)-4-methylazoline-2,5-dione (S01600),

phenylmethyl 4-({2-[(3,4-dimethyl-2,5-dioxoazolinyl)amino]-7-bromo-4-quinolyl}methyl)piperazinecarboxylate (S01683),

1-{[6-chloro-2-phenyl-3-(trifluoromethyl)(4-pyridyl)]amino}-3,4-dimethylazoline-2,5-dione (S01688),

3,4-dimethyl-1-({6-[3-(trifluoromethyl)phenyl](2-pyridyl)}amino)azoline-2,5-dione (S01691),

1-[(7-bromo-4-{[4-(phenylcarbonyl)piperazinyl]methyl}(2-quinolyl))amino]-3,4-dimethylazoline-2,5-dione (S01699),

3-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)-N-methyl-N-phenylpropanamide (S01759),

3,4-dimethyl-1-{[6-benzyl-5-(trifluoromethyl)(2-pyridyl)]amino}azoline-2,5-dione (S01762),

1-{[4-({4-[(2,4-dimethylphenyl)carbonyl]piperazinyl}methyl)-7-bromo(2-quinolyl)]amino}-3,4-dimethylazoline-2,5-dione (S01800),

1-{[7-bromo-4-({4-[(4-methoxyphenyl)carbonyl]piperazinyl}methyl)(2-quinolyl)]amino}-3,4-dimethylazoline-2,5-dione (S01801),

N-[6-chloro-5-(trifluoromethyl)(2-pyridyl)]-N-[4-(hydroxymethyl)-3-methyl-2,5-dioxoazolinyl]acetamide (S01820),

1-[(7-bromo-4-{[4-(phenylsulfonyl)piperazinyl]methyl}(2-quinolyl))amino]-3,4-dimethylazoline-2,5-dione (S01822),

1-[(4-chloro-8-methyl(2-quinolyl))amino]-3,4-dimethylazoline-2,5-dione (S00871),

tert-butyl 4-[({2-[(3,4-dimethyl-2,5-dioxoazolinyl)amino]-7-bromo-4-quinolyl}methyl)amino]piperidinecarboxylate (S01862),

tert-butyl 4-[4-({2-[(3,4-dimethyl-2,5-dioxoazolinyl)amino]-7-bromo-4-quinolyl}methyl)piperazinyl]piperidinecarboxylate (S01928),

1-[(4-{[4-(3,3-dimethylbutanoyl)piperazinyl]methyl}-7-bromo(2-quinolyl))amino]-3,4-dimethylazoline-2,5-dione (S01929),

Methylethyl 3-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)propanoate (S02022)

Methylpropyl 3-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)propanoate (S02264)

tert-Butyl 2-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)acetate (S02225)

1-{[6-Chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-3-(ethoxymethyl)-4-methylazoline-2,5-dione (S02366)

3-Butyl-1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methylazoline-2,5-dione (S03448)

1-{[6-Chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-3-[2-(2-methyl(1,3-dioxolan-2-yl))ethyl]azoline-2,5-dione (S03456)

1-{[6-Chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-3-[(2-methoxyethoxy)methyl]-4-methylazoline-2,5-dione (S03742)

1-{[6-Chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-(3-hydroxyhexyl)-3-methylazoline-2,5-dione (S03552)

1-{[6-Chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-(3-hydroxypentyl)-3-methylazoline-2,5-dione (S03745)

1-{[6-Chloro-5-(trilluoromethyl)(2-pyridyl)]amino}-4-methyl-3-[(3-methylbutoxy)methyl]azoline-2,5-dione (S03405)

3-(Butoxymethyl)-1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methylazoline-2,5-dione (S03518)

3-[(3,3-Dimethylbutoxy)methyl]-1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methylazoline-2,5-dione (S03747)

1-{[6-Chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-3-(2-ethoxyethyl)-4-methylazoline-2,5-dione (S03960)

1-{[6-Chloro-5-(trifluoro methyl)(2-pyridyl)]amino}-4-methyl-3-[(2-methylpropoxy)methyl]azoline-2,5-dione (S03963)

3-[(2,2-Dimethylpropoxy)methyl]-1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methylazoline-2,5-dione (S03962)

4-[(1,3-Dimethylbutoxy)methyl]-1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-3-methylazoline-2,5-dione (S03964)

4-[(tert-Butoxy)methyl]-1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-3-methylazoline-2,5-dione (S03873)

1-{[6-Chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-3-[2-(2-methylpropoxy)ethyl]azoline-2,5-dione (S03955)

1-{[6-Chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-3-[2-(3-methylbutoxy)ethyl]azoline-2,5-dione (S03956)

1-{[6-Chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-3-methyl-4-(2-propoxyethyl)azoline-2,5-dione (S04034);

and salts thereof.

6. The compound of claim 5 , wherein the compound is tert-butyl 3-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl) propanoate (S01860) or a salt thereof; having the following structure:

7. The compound of claim 5 , wherein the compound is ethyl 3-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)propanoate (S01861) or a salt thereof, having the following structure:

8. The compound of claim 5 , wherein the compound is 3,4-dimethyl-1-[(4,7,8-trichloro(2-quinolyl))amino]azoline-2,5-dione (S01078) or a salt thereof, having the following structure:

9. The compound of claim 5 , wherein the compound is 1-[(8-bromo-4-chloro(2-quinolyl))amino]-3,4-dimethylazoline-2,5-dione (S01247) or a salt thereof, having the following structure:

10. The compound of claim 5 , wherein the compound is tert-butyl4-({2-[(3,4-dimethyl-2,5-dioxoazolinyl)amino]-7-bromo-4-quinolyl}methyl) piperazinecarboxylate (S01589)or a salt thereof, having the following structure:

11. The compound of claim 5 , wherein the compound is methyl3-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)propanoate (S01648) or a salt thereof, having the following structure:

12. The compound of claim 5 , wherein the compound is 3-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)-N-methoxy-N-methylpropanamide (S01796) or a salt thereof, having the following structure:

13. The compound of claim 5 , wherein the compound is 1-{[7-bromo-4-({4-[(2-methoxyphenyl)carbonyl]piperazinyl}methyl)(2-quinolyl)]amino}-3,4-dimethylazoline-2,5-dione (S01879) or a salt thereof, having the following structure:

14. The compound of claim 5 , wherein the compound is 1-{[3-bromo-6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-3,4-dimethylazoline-2,5-dione (S01981) or a salt thereof, having the following structure:

15. The compound of claim 5 , wherein the compound is 1-{[6-chloro-3-(trifluoromethyl)(2-pyridyl)]amino}-3,4-dimethylazoline-2,5-dione (S00109) or a salt thereof, having the following structure:

16. The compound of claim 5 , wherein the compound is 1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]methylamino}-3,4-dimethylazoline-2,5-dione (S00170) or a salt thereof, having the following structure:

17. The compound of claim 5 , wherein the compound is 1-{[6-bromo-5-(trifluoromethyl)(2-pyridyl)]methylamino}-3,4-dimethylazoline-2,5-dione (S01007) or a salt thereof, having the following structure:

18. The compound of claim 5 , wherein the compound is 1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-3-(3-methylbutyl)azoline-2,5-dione (S01554), or a salt thereof, having the following structure:

19. The compound of claim 5 , wherein the compound is 1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-3-(methoxymethyl)-4-methyazoline-2,5-dione (S01599) or a salt thereof, having the following structure:

20. The compound of claim 5 , wherein the compound is 1-{[7,8-dichloro-4-(trifluoromethyl)(2-quinolyl)]amino}-3,4-dimethylazoline-2,5-dione (S01455) or a salt thereof, having the following structure:

21. The compound of claim 5 , wherein the compound is 3-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazol in-3-yl)-N,N-diethylpropanamide (S01711) or a salt thereof, having the following structure:

22. The compound of claim 5 , wherein the compound is diethyl 2-[(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)methyl]propane-1,3-dioate (S01712) or a salt thereof, having the following structure:

23. The compound of claim 5 , wherein the compound is N-(tert-butyl)-3-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)propanamide (S01758) or a salt thereof, having the following structure:

24. The compound of claim 5 , wherein the compound is 1-{[7-bromo-4-({4-[(3-methoxyphenyl)carbonyl]piperazinyl}methyl)(2-quinolyl)]amino}-3,4-dimethylazoline-2,5-dione (S01925) or a salt thereof, having the following structure:

25. The compound of claim 5 , wherein the compound is 1-{[6-bromo-5-(trifluoromethyl)(2-pyridyl)]amino}-3,4-dimethylazoline-2,5-dione (S00994) or a salt thereof, having the following structure:

26. The compound of claim 5 , wherein the compound is 1-[(4,8-dichloro(2-quinolyl))amino]-3,4-dimethylazoline-2,5-dione (S01005) or a salt thereof, having the following structure:

27. The compound of claim 5 , wherein the compound is 3,4-dimethyl-1-{[6-phenyl-5-(trifluoromethyl)(2-pyridyl)]amino}azoline-2,5-dione (S01266) or a salt thereof, having the following structure:

28. The compound of claim 5 , wherein the compound is 1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-3-(hydroxymethyl)-4-methylazoline-2,5-dione (S01470) or a salt thereof, having the following structure:

29. The compound of claim 5 , wherein the compound is N-(3,4-dimethyl-2,5-dioxoazolinyl)-N-[6-chloro-5-(trifluoromethyl)(2-pyridyl)]acetamide (S01473) or a salt thereof, having the following structure:

30. The compound of claim 5 , wherein the compound is 1-{[7-bromo-4-({4-[(2-chlorophenyl)carbonyl]piperazinyl}methyl)(2-quinolyl)]amino}-3,4-dimethylazoline-2,5-dione (S01878) or a salt thereof, having the following structure:

31. The compound of claim 5 , wherein the compound is 3-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)-N-methylpropanamide (S01883) or a salt thereof, having the following structure:

32. The compound of claim 5 , wherein the compound is 1-[(8-chloro(2-quinolyl))amino]-3,4-dimethylazoline-2,5-dione (S00585) or a salt thereof, having the following structure:

33. The compound of claim 5 , wherein the compound is 3,4-dimethyl-1-[(3,4,5-trichlorophenyl)amino]azoline-2,5-dione (S00832) or a salt thereof, having the following structure:

34. The compound of claim 5 , wherein the compound is 3,4-dimethyl-1-{[4-(trifluoromethyl)(2-quinolyl)]amino}azoline-2,5-dione (S00873) or a salt thereof, having the following structure:

35. The compound of claim 5 , wherein the compound is 1-[(7-bromo-4-chloro(2-quinolyl))amino]-3,4-dimethylazoline-2,5-dione (S01311) or a salt thereof, having the following structure:

36. The compound of claim 5 , wherein the compound is 1-{[6-(3-chloro-4-fluorophenyl)-5-(trifluoromethyl)(2-pyridyl)]amino}-(3,4-dimethylazoline-2,5-dione (S01313) or a salt thereof, having the following structure:

37. The compound of claim 5 , wherein the compound is 3,4-dimethyl-1-{[6-(2-methylpropyl)-5-(trifluoromethyl)(2-pyridyl)]amino}azoline-2,5-dione (S01457) or a salt thereof, having the following structure:

38. The compound of claim 5 , wherein the compound is 1-{[6-chloro-4-(trifluoromethyl)(2-pyridyl)]amino}-3,4-dimethylazoline-2,5-dione (S01737) or a salt thereof, having the following structure:

39. The compound of claim 5 , wherein the compound is methyl 3-(1-{[4-({4-[(tert-butyl)oxycarbonyl]piperazinyl}methyl)-7-bromo(2-quinolyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)propanoate (S01865) or a salt thereof, having the following structure:

40. The compound of claim 5 , wherein the compound is 1-({4-[(4-{[4-(dimethylamino)phenyl]carbonyl}piperazinyl)methyl]-7-bromo(2-quinolyl)}amino)-3,4-dimethylazoline-2,5-dione (S01880) or a salt thereof, having the following structure:

41. The compound of claim 5 , wherein the compound is 1-[(3-chloroisoquinolyl)amino]-3,4-dimethylazoline-2,5-dione (S01098) or a salt thereof, having the following structure:

42. The compound of claim 5 , wherein the compound is 1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-3-ethyl-4-methylazoline-2,5-dione (S01553) or a salt thereof, having the following structure:

43. The compound of claim 5 , wherein the compound is 1-{[4-chloro-6-phenyl-5-(trifluoromethyl)(2-pyridyl)]amino}-3,4-dimethyazoline-2,5-dione (S01734) or a salt thereof, having the following structure:

44. The compound of claim 5 , wherein the compound is N-[1-({2-[(3,4-dimethyl-2,5-dioxoazolinyl)amino]-7-bromo(4-quinolyl)}methyl)pyrrolidin-3-yl](tert-butoxy)carboxamide (S01864) or a salt thereof, having the following structure:

45. The compound of claim 5 , wherein the compound is 1-{[7-bromo-4-({4-[(4-fluorophenyl)carbonyl]piperazinyl}methyl)(2-quinolyl)]amino}-3,4-dimethylazoline-2,5-dione (S01877) or a salt thereof, having the following structure:

46. The compound of claim 5 , wherein the compound is 6-[(3,4-dimethyl-2,5-dioxoazolinyl)amino]-3-(trifluoromethyl)pyridine-2-carbonitrile (S01475) or a salt thereof, having the following structure:

47. The compound of claim 5 , wherein the compound is 2-{[6-chloro-5-(trifluoromethyl)-2-pyridyl]amino}-4,5,6,7-tetrahydroisoindole-1,3-dione (S00186) or a salt thereof, having the following structure:

48. The compound of claim 5 , wherein the compound is 1-{[4-bromo-3-(trifluoromethyl)phenyl]amino}-3,4-dimethylazoline-2,5-dione (S00516) or a salt thereof, having the following structure:

49. The compound of claim 5 , wherein the compound is 1-[(4-chloronaphthyl)amino]-3,4-dimethylazoline-2,5-dione (S00738) or a salt thereof, having the following structure:

50. The compound of claim 5 , wherein the compound is 1-[(4-chloro-6-methyl(2-quinolyl))amino]-3,4-dimethylazoline-2,5-dione (S00935) or a salt thereof, having the following structure:

51. The compound of claim 5 , wherein the compound is 1-[(4-bromonaphthyl)amino]-3,4-dimethylazoline-2,5-dione (S00942) or a salt thereof, having the following structure:

52. The compound of claim 5 , wherein the compound is 1-{[7-bromo-4-(hydroxymethyl)(2-quinolyl)]amino}-3,4-dimethylazoline-2,5-dione (S01037) or a salt thereof, having the following structure:

53. The compound of claim 5 , wherein the compound is {2-[(3,4-dimethyl-2,5-dioxoazolinyl)amino]-7-bromo-4-quinolyl}methyl acetate (S01047) or a salt thereof, having the following structure:

54. The compound of claim 5 , wherein the compound is 1-{[8-chloro-4-(4-methoxyphenyl)(2-quinolyl)]amino}-3,4-dimethylazoline-2,5-dione (S01191) or a salt thereof, having the following structure:

55. The compound of claim 5 , wherein the compound is 1-[(4-chlorobenzo[h]quinolin-2-y)amino]-3,4-dimethylazoline-2,5-dione (S01207) or a salt thereof, having the following structure:

56. The compound of claim 5 , wherein the compound is 1-[(7-bromo-4-{[4-benzylpiperazinyl]methyl}(2-quinolyl))amino]-3,4-dimethylazoline-2,5-dione (S01268) or a salt thereof, having the following structure:

57. The compound of claim 5 , wherein the compound is 1-{[6-(4-chlorophenyl)-5-(trifluoromethyl)(2-pyridyl)]amino}-3,4-dimethylazoline-2,5-dione (S01371) or a salt thereof, having the following structure:

58. The compound of claim 5 , wherein the compound is 3,4-dimethyl-1-{[6-(4-methylphenyl)-5-(trifluoromethyl)(2-pyridyl)]amino}azoline-2,5-dione (S01393) or a salt thereof, having the following structure:

59. The compound of claim 5 , wherein the compound is 1-{[6-(3-chlorophenyl)-5-(trifluoromethyl)(2-pyridyl)]amino}-3,4-dimethylazoline-2,5-dione (S01474) or a salt thereof, having the following structure:

60. The compound of claim 5 , wherein the compound is 1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]methylamino}-3-(methoxymethyl)-4-methylazoline-2,5-dione (S01600) or a salt thereof, having the following structure:

61. The compound of claim 5 , wherein the compound is phenylmethyl 4-({2-[(3,4-dimethyl-2,5-dioxoazolinyl)amino]-7-bromo-4-quinolyl}methyl) piperazinecarboxylate (S01683) a salt thereof, having the following structure:

62. The compound of claim 5 , wherein the compound is 1-{[6-chloro-2-phenyl-3-(trifluoromethyl)(4-pyridyl)]amino}-3,4-dimethylazoline-2,5-dione (S01688) or a salt thereof, having the following structure:

63. The compound of claim 5 , wherein the compound is 3,4-dimethyl-1-({6-[3-(trifluoromethyl)phenyl](2-pyridyl)}amino)azoline-2,5-dione (S01691) or a salt thereof, having the following structure:

64. The compound of claim 5 , wherein the compound is 1-[7-bromo-4-{[4-(phenylcarbonyl)piperazinyl]methyl}(2-quinolyl))amino]-3,4-dimethylazoline-2,5-dione (S01699) or a salt thereof, having the following structure:

65. The compound of claim 5 , wherein the compound is 3-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)-N-methyl-N-phenylpropanamide (S01759) or a salt thereof, having the following structure:

66. The compound of claim 5 , wherein the compound is 3,4-dimethyl-1-{[6-benzyl-5-(trifluoromethyl)(2-pyridyl)]amino}azoline-2,5-dione (S01762) or a salt thereof, having the following structure:

67. The compound of claim 5 , wherein the compound is 1-{[4-({4-[(2,4-dimethylphenyl)carbonyl]piperazinyl}methyl)-7-bromo(2-quinolyl)]amino}-3,4-dimethylazoline-2,5-dione (S01800) or a salt thereof, having the following structure:

68. The compound of claim 5 , wherein the compound is 1-{[7-bromo-4-({4-[(4-methoxyphenyl)carbonyl]piperazinyl}methyl)(2-quinolyl)]amino}-3,4-dimethylazoline-2,5-dione (S01801) or a salt thereof, having the following structure:

69. The compound of claim 5 , wherein the compound is N-[6-chloro-5-(trifluoromethyl)(2-pyridyl)]-N-[4-(hydroxymethyl)-3-methyl-2,5-dioxoazolinyl]acetamide (S01820) or a salt thereof, having the following structure:

70. The compound of claim 5 , wherein the compound is 1-[(7-bromo-4-{[4-(phenylsulfonyl)piperazinyl]methyl}(2-quinolyl))amino]-3,4-dimethylazoline-2,5-dione (S01822) or a salt thereof, having the following structure:

71. The compound of claim 5 , wherein the compound is 1-[(4-chloro-8-methyl(2-quinolyl))amino]-3,4-dimethylazoline-2,5-dione (S00871) or a salt thereof, having the following structure:

72. The compound of claim 5 , wherein the compound is tert-butyl 4-[({2-[(3,4-dimethyl-2,5-dioxoazolinyl)amino]-7-bromo-4-quinolyl}methyl)amino]piperidinecarboxylate (S01862) or a salt thereof, having the following structure:

73. The compound of claim 5 , wherein the compound is tert-butyl 4-[4-({2-[(3,4-dimethyl-2,5-dioxoazolinyl)amino]-7-bromo-4-quinolyl }methyl) piperazinyl]piperidinecarboxylate (S01928) or a salt thereof, having the following structure:

74. The compound of claim 5 , wherein the compound is 1-[(4-{[4-(3,3-dimethylbutanoyl)piperazinyl]methyl}-7-bromo(2-quinolyl))amino]-3,4-dimethylazoline-2,5-dione (S01929) or a salt thereof, having the following structure:

75. The compound of claim 5 , wherein the compound is methylethyl 3-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)propanoate (S02022) or a salt thereof, having the following structure:

76. The compound of claim 5 , wherein the compound is methylpropyl 3-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)propanoate (S02264) or a salt thereof, having the following structure:

77. The compound of claim 5 , wherein the compound is tert-butyl 2-(1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-2,5-dioxoazolin-3-yl)acetate (S02225) or a salt thereof, having the following structure:

78. The compound of claim 5 , wherein the compound is 1-{[6-Chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-3-(ethoxymethyl)-4-methylazoline-2,5-dione (S02366) or a salt thereof, having the following structure:

79. The compound of claim 5 , wherein the compound is 3-Butyl-1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methylazoline-2,5-dione (S03448) or a salt thereof, having the following structure:

80. The compound of claim 5 , wherein the compound is 1-{[6-Chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-3-[2-(2-methyl(1,3-dioxolan-2-yl))ethyl]azoline-2,5-dione (S03456) or a salt thereof, having the following structure:

81. The compound of claim 5 , wherein the compound is 1-{[6-Chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-3-[(2-methoxyethoxy)methyl]-4-methylazoline-2,5-dione (S03742) or a salt thereof, having the following structure:

82. The compound of claim 5 , wherein the compound is 1-{[6-Chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-(3-hydroxyhexyl)-3-methylazoline-2,5-dione (S03552) or a salt thereof, having the following structure:

83. The compound of claim 5 , wherein the compound is 1-{[6-Chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-(3-hydroxypentyl)-3-methylazoline-2,5-dione (S03745) or a salt thereof, having the following structure:

84. The compound of claim 5 , wherein the compound is 1-{[6-Chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-3-[(3-methylbutoxy)methyl]azoline-2,5-dione (S03405) or a salt thereof, having the following structure:

85. The compound of claim 5 , wherein the compound is 3-(Butoxymethyl)-1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methylazoline-2,5-dione (S03518) or a salt thereof, having the following structure:

86. The compound of claim 5 , wherein the compound is 3-[(3,3-Dimethylbutoxy)methyl]-1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methylazoline-2,5-dione (S03747) or a salt thereof, having the following structure:

87. The compound of claim 5 , wherein the compound is 1-{[6-Chloro-5-(tri tluoromethyl)(2-pyridyl)]amino}-3-(2-ethoxyethyl)-4-methyazoline-2,5-dione (S03960) or a salt thereof, having the following structure:

88. The compound of claim 5 , wherein the compound is 1-{[6-Chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-3-[(2-methylpropoxy)methyl]azoline-2,5-dione (S03963) or a salt thereof, having the following structure:

89. The compound of claim 5 , wherein the compound is 3-[(2,2-Dimethylpropoxy)methyl]-1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methylazoline-2,5-dione (S03962) or a salt thereof, having the following structure:

90. The compound of claim 5 , wherein the compound is 4-[(1,3-Dimethylbutoxy)methyl]-1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-3-methylazoline-2,5-dione (S03964) or a salt thereof, having the following structure:

91. The compound of claim 5 , wherein the compound is 4-[(tert-Butoxy)methyl]-1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-3-methylazoline-2,5-dione (S03873) or a salt thereof, having the following structure:

92. The compound of claim 5 , wherein the compound is 1-{[6-Chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-3-[2-(2-methylpropoxy)ethyl]azoline-2,5-dione (S03955) or a salt thereof, having the following structure:

93. The compound of claim 5 , wherein the compound is 1-{[6-Chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-4-methyl-3-[2-(3-methylbutoxy)ethyl]azoline-2,5-dione (S03956) or a salt thereof, having the following structure:

94. The compound of claim 5 , wherein the compound is 1-{[6-Chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-3-methyl-4-(2-propoxyethyl)azoline-2,5-dione (S04034) or a salt thereof, having the following structure:

95. A pharmaceutical composition comprising the compound of claim 1 in combination with a pharmaceutically acceptable excipient.