IP Library › Granted Patent US 8,597,646
Granted Patent B2
US 8,597,646 · App. 12/084,098 · Granted Dec 3, 2013

Methods and compositons featuring TGF-beta antagonists for the treatment of marfan syndrome and associated disorders

Inventors: Harry C. Dietz (Towson, MD); Daniel P. Judge (Baltimore, MD); Enid R. Neptune (Baltimore, MD); Ronald Cohn (Pikesville, MD); Jennifer Habashi (Annapolis, MD)
Assignee: The Johns Hopkins University
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Quick Facts
Patent No.
US 8,597,646
App. No.
12/084,098
Granted
Dec 3, 2013
Kind
B2
Abstract

The instant invention provides methods and compositions for the treatment and prevention of Marfan syndrome and related diseases, disorders and conditions. The invention further provides pharmaceutical compositions and kits for the treatment and prevention of Marfan syndrome and related diseases, disorders and conditions.

Claims (2)

1. A method of treating a subject having a Marfan-associated condition selected from the group consisting of aneurysm, an aortic aneurysm, emphysema, valve disease, hypotonia, and myopathy comprising:

administering to the subject post-natally an effective amount of an antibody or antibody fragment selected from the group consisting of an F(ab) fragment, F(ab) 2 fragment, Fv fragment, or a single chain antibody that binds and neutralizes TGFβ; thereby treating the subject.

Assignments (2)
CONFIRMATORY LICENSE Recorded Oct 27, 2017
From: JOHNS HOPKINS UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 044637/0296 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 25, 2008
From: DIETZ, HARRY C.; JUDGE, DANIEL P.; NEPTUNE, ENID R.; COHN, RONALD; HABASHI, JENNIFER
To: JOHNS HOPKINS UNIVERSITY, THE
Reel/Frame 020899/0746 →
Continuity (2)
Provisional Application 60729976 · Oct 25, 2005
Related Publication 20100034806A1 · Feb 11, 2010