Morpholine carboxamide prokineticin receptor antagonists

1. A compound of the formula I:

wherein:

A is selected from the group consisting of phenyl, napthyl and heteroaryl;

B is selected from the group consisting of:

X and Y are independently —(C 1-6 alkylene)-, which is unsubstituted or substituted with one or more substituents selected from R 13 ;

R 1a , R 1b and R 1c may be absent if the valency of A does not permit such substitution and are independently selected from the group consisting of:

(1) hydrogen,

(2) halogen,

(3) hydroxyl,

(4) —(C═O) m —O p -C 1-6 alkyl, where m is 0 or 1, p is 0 or 1 (wherein if m is 0 or p is 0, a bond is present) and where the alkyl is unsubstituted or substituted with one or more substituents selected from R 13 ,

(5) —(C═O) m —O p -C 3-6 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents selected from R 13 ,

(6) —(C═O) m —C 2-4 alkenyl, where the alkenyl is unsubstituted or substituted with one or more substituents selected from R 13 ,

(7) —(C═O) m —O p -phenyl or —(C═O) m —O p -napthyl, where the phenyl or napthyl is unsubstituted or substituted with one or more substituents selected from R 13 ,

(8) —(C═O) m —O p -heterocycle, where the heterocycle is unsubstituted or substituted with one or more substituents selected from R 13 ,

(9) —(C═O) m —NR 10 R 11 , wherein R 10 and R 11 are independently selected from the group consisting of:

(a) hydrogen,

(b) C 1-6 alkyl, which is unsubstituted or substituted with R 13 ,

(c) C 3-6 alkenyl, which is unsubstituted or substituted with R 13 ,

(d) cycloalkyl which is unsubstituted or substituted with R 13 ,

(e) phenyl, which is unsubstituted or substituted with R 13 , and

(f) heterocycle, which is unsubstituted or substituted with R 13 ,

(10) —S(O) 2 —NR 10 R 11 ,

(11) —S(O) t —R 12 , where t is 0, 1 or 2 and where R 12 is selected from the definitions of R 10 and R 11 ,

(12) —CO 2 H,

(13) —CN, and

(14) —NO 2 ;

R 2 is selected from the group consisting of:

(1) hydrogen,

(2) C 1-6 alkyl, which is unsubstituted or substituted with one or more substituents selected from R 13 ,

(3) —C 3-6 cycloalkyl, which is unsubstituted or substituted with one or more substituents selected from R 13 ,

(4) -phenyl which is unsubstituted or substituted with one or more substituents selected from R 13 ;

R 3 is independently selected from:

(1) hydrogen,

(2) halogen,

(3) hydroxy, and

(4) C 1-6 alkyl, which is unsubstituted or substituted with one or more substituents selected from R 13 ,

or two R 3 at the same position are joined to form a furan, oxetane or pyran ring,

or two R 3 at adjacent positions are joined to form a phenyl ring;

R 13 is selected from the group consisting of:

(1) halogen,

(2) hydroxyl,

(3) —(C═O) m —O p -C 1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents selected from R 14 ,

(4) —O n —(C 1-3 )perfluoroalkyl,

(5) —(C═O) m —O p -C 3-6 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents selected from R 14 ,

(6) —(C═O) m —C 2-4 alkenyl, where the alkenyl is unsubstituted or substituted with one or more substituents selected from R 14 ,

(7) —(C═O) m —O p -phenyl or —(C═O) m —O p -napthyl, where the phenyl or napthyl is unsubstituted or substituted with one or more substituents selected from R 14 ,

(8) —(C═O) m —O p -heterocycle, where the heterocycle is unsubstituted or substituted with one or more substituents selected from R 14 ,

(9) —(C═O) m —NR 10 R 11 ,

(10) —S(O) 2 —NR 10 R 11 ,

(11) —S(O) t —R 12 ,

(12) —CO 2 H,

(13) —CN, and

(14) —NO 2 ;

R 14 is selected from the group consisting of:

(1) hydroxyl,

(2) halogen,

(3) C 1-6 alkyl,

(4) —C 3-6 cycloalkyl,

(5) —O—C 1-6 alkyl,

(6) —O(C═O)—C 1-6 alkyl,

(7) —NH—C 1-6 alkyl,

(8) phenyl,

(9) heterocycle,

(10) —CO 2 H, and

(11) —CN;

n is 0, 1, 2, 3, 4, 5 or 6;

q is 0, 1, 2, 3 or 4;

or an N-oxide thereof or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 of the formula Ib:

or a pharmaceutically acceptable salt thereof.

3. The compound of claim 1 of the formula Ic:

or a pharmaceutically acceptable salt thereof.

4. The compound of claim 1 of the formula Id:

or a pharmaceutically acceptable salt thereof.

5. The compound of claim 1 of the formula If:

or a pharmaceutically acceptable salt thereof.

6. The compound of claim 1 of the formula Ig:

or a pharmaceutically acceptable salt thereof.

7. The compound of claim 1 wherein A is phenyl.

8. The compound of claim 1 wherein A is pyridyl.

9. The compound of claim 1 wherein X is —CH 2 —.

10. The compound of claim 1 wherein Y is —CH 2 —.

11. The compound of claim 1 wherein R 1a , R 1b and R 1c are independently selected from the group consisting of:

(1) hydrogen,

(2) halogen,

(3) C 1-6 alkyl, which is unsubstituted or substituted with halogen, hydroxyl, phenyl or

—O—C 1-6 alkyl,

(4) C 2-4 alkenyl, which is unsubstituted or substituted with C 3-6 cycloalkyl or phenyl,

(5) —O—C 1-6 alkyl, which is unsubstituted or substituted with halogen, hydroxyl, phenyl or

—O—C 1-6 alkyl,

(6) phenyl, which is unsubstituted or substituted with halogen, hydroxyl, C 1-6 alkyl, —O—C 1-6 alkyl, —SH, —NO 2 , —CO 2 H, or —CN,

(7) —NR 10 R 11 , wherein R 10 and R 11 are independently selected from hydrogen and

C 1-6 alkyl,

(8) tetrazolyl,

(9) thienyl,

(10) triazolyl,

(11) benzothienyl,

(12) pyrazolyl,

(13) imidazolyl,

(14) —NO 2 ,

(15) hydroxyl, and

(16) —CN.

12. The compound of claim 11 wherein R 1b is hydrogen, R 1c is hydrogen and R 1a selected from the group consisting of:

(1) hydrogen,

(2) fluoro,

(3) —O—C 1-6 alkyl, and

(4) phenyl.

13. The compound of claim 7 wherein A is phenyl, R 1b is hydrogen, R 1c is hydrogen and R 1a selected from the group consisting of:

(1) hydrogen,

(2) fluoro, and

(3) —O—CH 3 .

14. The compound of claim 1 wherein R 2 is selected from the group consisting of:

(1) C 1-6 alkyl, and

(2) C 1-6 alkyl-C 3-6 cycloalkyl.

15. The compound of claim 1 wherein R 3 is independently selected from:

(1) hydrogen,

(2) halogen, and

(3) C 1-6 alkyl.

16. The compound of claim 15 wherein R 3 is independently selected from:

(1) hydrogen,

(2) fluoro, and

(3) methyl.

17. A compound which is selected from the group consisting of:

4-Benzyl-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

(2R)—N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-(2-methoxybenzyl)morpholine-2-carboxamide;

4-Benzyl-N-isobutyl-N-(2,3,4,5-tetrahydro-1,6-benzodioxocin-8-ylmethyl)morpholine-2-carboxamide;

4-Benzyl-N-isobutyl-N-[(3,3,4,4-tetrafluoro-2,3,4,5-tetrahydro-1,6-benzodioxocin-8-yl)methyl]-morpholine-2-carboxamide;

4-Benzyl-N-[(3,3-difluoro-3,4-dihydro-2H-1,5-benzodioxepin-7-yl)methyl]-N-isobutylmorpholine-2-carboxamide;

(2R)—N-[(3-fluoro-3,4-dihydro-2H-1,5-benzodioxepin-7-yl)methyl]-N-isobutyl-4-(2-methoxybenzyl)morpholine-2-carboxamide;

4-benzyl-N-(2,3-dihydro-1-benzofuran-5-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-benzyl-N-[(5,5-dimethyl-2,3,4,5-tetrahydro-1-benzoxepin-7-yl)methyl]-N-isobutylmorpholine-2-carboxamide;

(2R)—N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(3-methoxypyrazin-2-yl)methyl]morpholine-2-carboxamide;

(2R)—N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(5-methoxypyridin-3-yl)methyl]morpholine-2-carboxamide;

(2R)—N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(2-methoxy-6-methylpyrimidin-4-yl)methyl]morpholine-2-carboxamide;

(2R)—N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(3-methoxypyridin-4-yl)methyl]morpholine-2-carboxamide;

(2R)—N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(4-methoxypyrimidin-5-yl)methyl]morpholine-2-carboxamide;

(2R)—N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-(2-methoxybenzyl)morpholine-2-carboxamide;

N-Isobutyl-4-(2-methoxybenzyl)-N-(2,3,4,5-tetrahydro-1-benzoxepin-8-ylmethyl)morpholine-2-carboxamide;

4-Benzyl-N-isobutyl-N-(2,3,4,5-tetrahydro-1-benzoxepin-8-ylmethyl)morpholine-2-carboxamide;

N-Isobutyl-4-(2-methoxybenzyl)-N-(2,3,4,5-tetrahydro-1-benzoxepin-7-ylmethyl)morpholine-2-carboxamide;

4-Benzyl-N-isobutyl-N-(2,3,4,5-tetrahydro-1-benzoxepin-8-ylmethyl)morpholine-2-carboxamide;

N-(3,4-Dihydro-2H-chromen-7-ylmethyl)-N-isobutyl-4-(2-methoxybenzyl)morpholine-2-carboxamide;

4-Benzyl-N-(3,4-dihydro-2H-chromen-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-Dihydro-2H-chromen-6-ylmethyl)-N-isobutyl-4-(2-methoxybenzyl)morpholine-2-carboxamide;

N-[(9-Hydroxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)methyl]-N-isobutyl-4-(2-methoxybenzyl)morpholine-2-carboxamide;

4-Benzyl-N-[(9-hydroxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)methyl]-N-isobutylmorpholine-2-carboxamide;

N-Isobutyl-4-(2-methoxybenzyl)-N-[(9-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)methyl]morpholine-2-carboxamide;

4-Benzyl-N-isobutyl-N-[(9-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)methyl]morpholine-2-carboxamide;

N-Isobutyl-4-(2-methoxybenzyl)-N-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-ylmethyl)morpholine-2-carboxamide;

4-Benzyl-N-isobutyl-N-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-ylmethyl)morpholine-2-carboxamide;

4-benzyl-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

(R)-4-benzyl-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

(S)-4-benzyl-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-benzyl-N-cyclopentyl-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)morpholine-2-carboxamide;

4-benzyl-N-(cyclohexylmethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)morpholine-2-carboxamide;

4-benzyl-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-(2,2-dimethylpropyl)morpholine-2-carboxamide;

4-benzyl-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-propylmorpholine-2-carboxamide;

4-benzyl-N-(cyclopropylmethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)morpholine-2-carboxamide;

4-benzyl-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)morpholine-2-carboxamide;

N-(1,3-benzodioxol-5-ylmethyl)-4-benzylmorpholine-2-carboxamide;

N-(1,3-benzodioxol-5-ylmethyl)-4-benzyl-N-isobutylmorpholine-2-carboxamide;

4-benzyl-N-(cyclopentylmethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)morpholine-2-carboxamide;

4-cyclobutyl-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-cyclopentyl-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydroL1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-isopropylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-(4-fluorobenzyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-(pyridin-2-ylmethyl)morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-(2-phenylethyl)morpholine-2-carboxamide;

4-benzyl-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-benzyl-N-[1-(2,3-dihydro-1,4-benzodioxin-6-ypethyl]-N-isobutylmorpholine-2-carboxamide;

4-benzyl-N-(2,3-dihydro-1-benzofuran-5-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-benzyl-N-isobutyl-N-[(3-oxo-1,3-dihydro-2-benzofuran-5-yl)methyl]morpholine-2-carboxamide;

4-benzyl-N-[(2,2-dimethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-N-isobutylmorpholine-2-carboxamide;

(2S)-4-benzyl-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

(2R)-4-benzyl-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-benzyl-N-(2,3-dihydro-1-benzofuran-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[1-phenylethyl)morpholine-2-carboxamide;

4-benzyl-N-(3,4-dihydro-2H-chromen-8-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-benzyl-N-(3,4-dihydro-2H-chromen-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-(2,3,4-trifluorobenzyl)morpholine-2-carboxamide;

4-[(4-chloro-1-methyl-1H-pyrazol-3-yl)methyl]-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-(2,3,5,6-tetrafluorobenzyl)morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)methyl]-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[(1-methyl-1H-pyrrol-2-yl)methyl]morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-(2-furylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[(5-methyl-2-furyl)methyl]morpholine-2-carboxamide;

4[4-(diethylamino)-2-hydroxybenzyl]-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-(2-methylbenzyl)morpholine-2-carboxamide;

4-[4-(acetylamino)benzyl]-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-[4-(dimethylamino)benzyl]-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[(5-methyl-2-thienyl)methyl]morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[(6-methylpyridin-2-yl)methyl]morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-(4-hydroxy-3,5-dimethylbenzyl)-N-isobutylmorpholine-2-carboxamide;

4-(1,3-benzodioxol-5-ylmethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[4-(methylthio)benzyl]morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[4-(trifluoromethyl)benzyl]morpholine-2-carboxamide;

4-[3,5-bis(trifluoromethyl)benzyl]-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-(3,5-difluorobenzyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-(3-furylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-{[4-(dimethylamino)-1-naphthyl]methyl}-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-(4-propoxybenzyl)morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-[(5-ethyl-2-furyl)methyl]-N-isobutylmorpholine-2-carboxamide;

4-(2-chloro-4-fluorobenzyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[4-(trifluoromethoxy)benzyl]morpholine-2-carboxamide;

4-[(6,8-dichloro-4-oxo-4H-chromen-3-yl)methyl]-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-[(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)methyl]-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-(biphenyl-4-ylmethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[(1-methyl-1H-imidazol-2-yl)methyl]morpholine-2-carboxamide;

4-[(4′-chlorobiphenyl-4-yl)methyl]-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-(1-benzothien-2-ylmethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-(2,5-difluorobenzyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[3-(trifluoromethyl)benzyl]morpholine-2-carboxamide;

4-(4-cyanobenzyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-(2-fluorobenzyl)-N-isobutylmorpholine-2-carboxamide;

4-(2,4-difluorobenzyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-(2-cyanobenzyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-(4-methoxybenzyl)morpholine-2-carboxamide;

4-(3-chlorobenzyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-(4-chlorobenzyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-(3,4-dimethylbenzyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[(2′-methylbiphenyl-4-yl)methyl]morpholine-2-carboxamide;

4-(2-chlorobenzyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-(2-methoxybenzyl)morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-(3-methoxybenzyl)morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-(1H-indol-3-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[1,3-thiazol-4-ylmethyl)morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[(2-phenylimidazo[1,2-a]pyridin-3-yl)methyl]morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-{4-[(4-methoxybenzyl)oxy]benzyl} morpholine-2-carboxamide;

4-{[2-(diethylamino)-1,3-thiazol-5-yl]methyl}-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-(1,3-benzothiazol-2-ylmethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[(1-methyl-1H-pyrazol-3-yl)methyl]morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-[(1,3-diphenyl-1H-pyrazol-4-yl)methyl]-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[(1-methyl-1H-pyrazol-4-yl)methyl]morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-(pyrazin-2-ylmethyl)morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[(1-methyl-1,2,3,4-tetrahydroquinolin-6-yl)methyl]morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[(5-piperidin-1-yl-2-furyl)methyl]morpholine-2-carboxamide;

4-(biphenyl-2-ylmethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-(biphenyl-3-ylmethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[(2′-methylbiphenyl-3-yl)methyl]morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[1-(1,3-thiazol-2-yl)-1H-pyrrol-2-yl]methyl)morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[(4-methyl-1H-imidazol-2-yl)methyl]morpholine-2-carboxamide;

4-{[1-(5-chloropyridin-2-yl)-1H-pyrrol-2-yl]methyl}-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[(2-phenyl-1,3-thiazol-5-yl)methyl]morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[(4-phenyl-1,3-thiazol-2-yl)methyl]morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[(6-methylimidazol[2,1-b][1,3]thiazol-5-yl)methyl]morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-[(1,5-dimethyl-1H-pyrazol-4-yl)methyl]-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[1,3-oxazol-5-ylmethyl)morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[(1-methyl-3-phenyl-1H-pyrazol-4-yl)methyl]morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[(1-phenyl-1H-pyrazol-4-yl)methyl]morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[(1-pyridin-2-yl-1H-pyrrol-2-yl)methyl]morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-{[5-(methoxymethyl)-2-furyl]methyl} morpholine-2-carboxamide;

4-[(2-chloro-6-methylpyridin-4-yOmethyl]-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-(4-cyano-3-fluorobenzyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-(2,1,3-benzoxadiazol-5-ylmethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[(1-isopropyl-1H-pyrazol-4-yl)methyl]morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-(isoxazol-3-ylmethyl)morpholine-2-carboxamide;

4-[3-(cyclopentyloxy)benzyl]-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-[2-(cyclopentyloxy)benzyl]-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-(2,1,3-benzoxadiazol-4-ylmethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-[(6-fluoro-1H-benzimidazol-2-yl)methyl]-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[4-(2-oxopyrrolidin-1-yl)benzyl]morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-(pyrazolo[1,5-a]pyridin-3-ylmethyl)morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-{[1-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl}-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-(pyrazolo[1,5-a]pyridin-2-ylmethyl)morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-(2-methoxybenzyl)morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-(3-methoxybenzyl)morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(1-methyl-1H-pyrazol-4-yl)methyl]morpholine-2-carboxamide;

4-[(2-chloro-6-methylpyridin-4-yl)methyl]-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-(pyrazolo[1,5-a]pyridin-3-ylmethyl)morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-[(2-methoxypyridin-3-yl)methyl]morpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-[(3-fluoropyridin-4-yl)methyl]-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-(2-fluoro-5-methoxybenzyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-(5-fluoro-2-methoxybenzyl)-N-isobutylmorpholine-2-carboxamide;

N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-[(5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(4-methoxypyridin-3-yl)methyl]morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-[(5-fluoro-2-methoxypyridin-3-yl)methyl]-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-[(3-fluoropyridin-4-yl)methyl]-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-(2-fluoro-5-methoxybenzyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-(5-fluoro-2-methoxybenzyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-[(5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]-N-isobutylmorpholine-2-carboxamide;

(2R)—N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(3-methoxypyridin-4-yl)methyl]morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-(4-hydroxybutyl)-N-isobutylmorpholine-2-carboxamide;

4-benzyl-N-isobutyl-N-(2,3,4,5-tetrahydro-1,6-benzodioxocin-8-ylmethyl)morpholine-2-carboxamide;

(2R)-4-benzyl-N-isobutyl-N-(2,3,4,5-tetrahydro-1-benzoxepin-7-ylmethyl)morpholine-2-carboxamide;

(2S)—N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(4-methoxypyridin-3-yl)methyl]morpholine-2-carboxamide;

(2R)—N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(4-methoxypyridin-3-yl)methyl]morpholine-2-carboxamide;

(2R)—N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(3-methoxypyrazin-2-yl)methyl]morpholine-2-carboxamide;

(2R)—N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(2-methoxy-6-methylpyrimidin-4-yl)methyl]morpholine-2-carboxamide;

8-[(4-benzylmorpholin-2-yl)carbonyl]-3,4,7,8,9,10-hexahydro-2H-[1,4]dioxepino[2,3-g]isoquinoline

8-{[4-(2-methoxybenzyl)morpholin-2-yl]carbonyl}-3,4,7,8,9,10-hexahydro-2H-[1,4]dioxepino[2,3-g]isoquinoline

(2R)—N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-isobutyl-4-(2-methoxybenzyl)morpholine-2-carboxamide;

(2R)—N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-(2-methoxybenzyl)morpholine-2-carboxamide;

(2R)-4-[(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)methyl]-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

(2S)-4-[(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)methyl]-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]-N-isobutylmorpholine-2-carboxamide;

N-isobutyl-N-(2,3,4,5-tetrahydro-1,6-benzodioxocin-8-ylmethyl)morpholine-2-carboxamide;

N-isobutyl-4-(2-methoxybenzyl)-N-(2,3,4,5-tetrahydro-1,6-benzodioxocin-8-ylmethyl)morpholine-2-carboxamide;

4-[(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)methyl]-N-isobutyl-N-(2,3,4,5-tetrahydro-1,6-benzodioxocin-8-ylmethyl)morpholine-2-carboxamide;

4-benzyl-N-isobutyl-N-[(3,3,4,4-tetrafluoro-2,3,4,5-tetrahydro-1,6-benzodioxocin-8-yl)methyl]morpholine-2-carboxamide;

(2R)—N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(4-methoxypyrimidin-5-yl)methyl]morpholine-2-carboxamide;

(2R)—N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(5-methoxypyridin-3-yl)methyl]morpholine-2-carboxamide;

4-benzyl-N-[(3,3-difluoro-3,4-dihydro-2H-1,5-benzodioxepin-7-yl)methyl]-N-isobutylmorpholine-2-carboxamide;

N-isobutyl-4-(2-methoxybenzyl)-N-(2,3,4,5-tetrahydro-1-benzoxepin-8-ylmethyl)morpholine-2-carboxamide;

4-benzyl-N-isobutyl-N-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-ylmethyl)morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-[(1,2-dimethyl-1H-indol-3-yl)methyl]-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(5-methoxy-1,3-dimethyl-1H-pyrazol-4-yl)methyl]morpholine-2-carboxamide;

4-[(5-chloro-1-methyl-1H-pyrazol-4-yl)methyl]-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-{2-[(trifluoromethyl)thio]benzyl}morpholine-2-carboxamide;

4-benzyl-N-isobutyl-N-(2,3,4,5-tetrahydro-1-benzoxepin-8-ylmethyl)morpholine-2-carboxamide;

4-benzyl-N-(3,4-dihydro-2H-chromen-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-chromen-7-ylmethyl)-N-isobutyl-4-(2-methoxybenzyl)morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-[(2,5-dimethyl-3-furyl)methyl]-N-isobutylmorpholine-2-carboxamide;

N-(2-methylpropyl)-4-(phenylmethyl)-N-[(3,4,5,6-tetrahydro-2H-1,7-benzodioxonin-9-yl)methyl]morpholine-2-carboxamide;

4-benzyl-N-(2,3,4,5,6,7-hexahydro-1,8-benzodioxecin-10-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-benzyl-N-isobutyl-N-(spiro[1,5-benzodioxepine-3,3′-oxetan]-7-ylmethyl)morpholine-2-carboxamide;

N-(2,3,4,5,6,7-hexahydro-1,8-benzodioxecin-10-ylmethyl)-N-isobutyl-4-(2-methoxybenzyl)morpholine-2-carboxamide;

N-isobutyl-4-(2-methoxybenzyl)-N-(spiro[1,5-benzodioxepine-3,3′-oxetan]-7-ylmethyl)morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(1-methyl-1H-indol-3-yl)methyl]morpholine-2-carboxamide;

4-[(2-chloro-1-methyl-1H-indol-3-yl)methyl]-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(2-methylimidazo[1,2-a]pyridin-3-yl)methyl]morpholine-2-carboxamide;

4-benzyl-N-(6,11-dihydrodibenzo[b,f][1,4]dioxocin-2-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-isobutyl-4-(2-methoxybenzyl)-N-(3,4,5,6-tetrahydro-2H-1,7-benzodioxonin-9-ylmethyl)morpholine-2-carboxamide;

N-(6,11-dihydrodibenzo[b,f][1,4]dioxocin-2-ylmethyl)-N-isobutyl-4-(2-methoxybenzyl)morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-(pyridin-3-ylmethyl)morpholine-2-carboxamide;

4-[(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-(pyridin-4-ylmethyl)morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-(2,5-dimethoxybenzyl)-N-isobutylmorpholine-2-carboxamide;

4-(1,3-benzodioxol-4-ylmethyl)-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-(2,3-dihydro-1,4-benzodioxin-5-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-(3,4-dihydro-2H-1,5-benzodioxepin-6-ylmethyl)-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(6-methylpyridin-2-yl)methyl]morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-[(3,5-dimethylisoxazol-4-yl)methyl]-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-(2,3-dimethoxybenzyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-(2,6-dimethoxybenzyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-(2-fluoro-3-methoxybenzyl)-N-isobutylmorpholine-2-carboxamide;

4-[(2-chloropyridin-3-ylmethyl]-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(6-methoxypyridin-3-yl)methyl]morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-(2-ethoxybenzyl)-N-isobutylmorpholine-2-carboxamide;

4-[(6-chloropyridin-3-yl)methyl]-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-(4-fluoro-3-methoxybenzyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(2-methoxypyridin-3-yl)methyl]morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[2-(trifluoromethoxy)benzyl]morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-(3-ethoxybenzyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-(2-fluoro-6-methoxybenzyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-(1,6-naphthyridin-8-ylmethyl)morpholine-2-carboxamide;

4-benzyl-N-isobutyl-N-[(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-5-yl)methyl]morpholine-2-carboxamide;

(2R)—N-[(3-fluoro-3,4-dihydro-2H-1,5-benzodioxepin-7-yl)methyl]-N-isobutyl-4-(2-methoxybenzyl)morpholine-2-carboxamide;

(2R)—N-{[3-(benzyloxy)-3,4-dihydro-2H-1,5-benzodioxepin-7-yl]methyl}-N-isobutyl-4-(2-methoxybenzyl)morpholine-2-carboxamide;

(2R)—N-{[(3R)-3-hydroxy-3,4-dihydro-2H-1,5-benzodioxepin-7-yl]methyl}-N-isobutyl-4-(2-methoxybenzyl)morpholine-2-carboxamide;

(2R)—N-{[(3S)-3-hydroxy-3,4-dihydro-2H-1,5-benzodioxepin-7-yl]methyl}-N-isobutyl-4-(2-methoxybenzyl)morpholine-2-carboxamide;

4-[(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)methyl]-N-isobutyl-N-(2,3,4,5-tetrahydro-1-benzoxepin-7-ylmethyl)morpholine-2-carboxamide;

N-isobutyl-4-(2-methoxybenzyl)-N-(2,3,4,5-tetrahydro-1-benzoxepin-7-ylmethyl)morpholine-2-carboxamide;

4-benzyl-N-(3,4-dihydro-2H-1,5-benzodioxepin-6-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-benzyl-N-isobutyl-N-[(3-methyl-3,4-dihydro-2H-1,5-benzodioxepin-7-yl)methyl]morpholine-2-carboxamide;

4-benzyl-N-[(9-hydroxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)methyl]-N-isobutylmorpholine-2-carboxamide;

4-benzyl-N-isobutyl-N-[(9-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)methyl]morpholine-2-carboxamide;

N-[(9-hydroxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)methyl]-N-isobutyl-4-(2-methoxybenzyl)morpholine-2-carboxamide;

N-isobutyl-4-(2-methoxybenzyl)-N-[(9-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)methyl]morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-(3-methoxy-4-methylbenzyl)morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-(4-fluoro-2-methoxybenzyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-(5-isopropyl-2-methoxybenzyl)morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-(2,3-dihydro-1-benzofuran-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

4-(4-chloro-2-fluoro-5-methoxybenzyl)-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-[(2-hydroxypyridin-4-yl)methyl]-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[3-(trifluoromethoxy)benzyl]morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(2-methylimidazo[1,2-a]pyrimidin-3-yl)methyl]morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-(pyridazin-4-ylmethyl)morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-[(3-methylpyridazin-4-yl)methyl]morpholine-2-carboxamide;

4-benzyl-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-2-methylmorpholine-2-carboxamide;

4-benzyl-N-(2,3-dihydro-1H-inden-5-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

(2R)—N-(3,4-dihydro-2H-chromen-7-ylmethyl)-N-isobutyl-4-(2-methoxybenzyl)morpholine-2-carboxamide;

N-isobutyl-4-(2-methoxybenzyl)-N-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-ylmethyl)morpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-(2-hydroxybenzyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-(3-fluoro-2-methoxybenzyl)-N-isobutylmorpholine-2-carboxamide;

(2R)—N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-(2,3-dihydro-1-benzofuran-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

(2R)—N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-(4-fluoro-2-methoxybenzyl)-N-isobutylmorpholine-2-carboxamide;

N-(3,4-dihydro-2H-chromen-6-ylmethyl)-N-isobutyl-4-(2-methoxybenzyl)morpholine-2-carboxamide;

(2R)—N-[3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]methyl-N-isobutyl-4-(2-methoxybenzyl)morpholine-2-carboxamide;

(−)-(2R)—N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-(4-fluoro-3-methoxybenzyl)-N-isobutylmorpholine-2-carboxamide;

(−)-(2R)-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-(2-fluoro-5-methoxybenzyl)-N-isobutylmorpholine-2-carboxamide;

(−)-(2R)-4-(2-fluoro-5-methoxybenzyl)-N-isobutyl-N-(2,3,4,5-tetrahydro-1-benzoxepin-8-ylmethyl)morpholine-2-carboxamide;

(−)-(2R)-4-[(2-chloro-6-methylpyridin-4-yl)methyl]-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide;

(−)-(2R)—N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutyl-4-(quinolin-8-ylmethyl)morpholine-2-carboxamide;

(−)-(2R)—N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-(3-fluoro-2-hydroxybenzyl)-N-isobutylmorpholine-2-carboxamide;

(−)-(2R)—N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-(3-hydroxybenzyl)-N-isobutylmorpholine-2-carboxamide;

(−)-(2R)—N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-(2-hydroxy-5-methoxybenzyl)-N-isobutylmorpholine-2-carboxamide;

(−)-(2R)—N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-4-{[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]methyl}-N-isobutylmorpholine-2-carboxamide;

(2R)—N-isobutyl-4-(3-methoxy-4-methylbenzyl)-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)—N-isobutyl-4-(2-methoxy-4-methylbenzyl)-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-(2,3-dihydro-1-benzofuran-7-ylmethyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-(2-hydroxybenzyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-(4-chloro-2-fluoro-5-methoxybenzyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-(4-fluoro-2-methoxybenzyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-(2-fluoro-6-methoxybenzyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-(3-ethoxybenzyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-(4-fluoro-3-methoxybenzyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-(2-ethoxybenzyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-[(2-chloropyridin-3-yl)methyl]-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-(2-fluoro-3-methoxybenzyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-(2,6-dimethoxybenzyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-(2,3-dimethoxybenzyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-[(3,5-dimethylisoxazol-4-yl)methyl]-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)—N-isobutyl-4-[(6-methylpyridin-2-yl)methyl]-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)—N-isobutyl-N-(quinolin-6-ylmethyl)-4-[(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]morpholine-2-carboxamide;

(2R)-4-(3,4-dihydro-2H-1,5-benzodioxepin-6-ylmethyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-(2,3-dihydro-1,4-benzodioxin-5-ylmethyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-(1,3-benzodioxol-4-ylmethyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-(2,5-dimethoxybenzyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-[(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-[(2-chloro-1-methyl-1H-indol-3-yl)methyl]-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)—N-isobutyl-4-[(1-methyl-1H-pyrazol-4-yl)methyl]-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-(4-chlorobenzyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide

(2R)-4-[(2-chloro-6-methylpyridin-4-yl)methyl]-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-(3-chlorobenzyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-(2,4-difluorobenzyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-(2-fluorobenzyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-[(5-fluoro-2-methoxypyridin-3-yl)methyl]-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-(5-fluoro-2-methoxybenzyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-(2-fluoro-5-methoxybenzyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)—N-isobutyl-4-[(2-methoxypyridin-3-yl)methyl]-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-[(4-bromo-2-thienyl)methyl]-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-[(1,5-dimethyl-1H-pyrazol-4-yl)methyl]-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)—N-isobutyl-4-(3-methoxybenzyl)-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-(3,4-dimethylbenzyl)-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)—N-isobutyl-N-(quinolin-6-ylmethyl)-4-[(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]morpholine-2-carboxamide;

(2R)—N-isobutyl-4-[(5-methyl-2-thienyl)methyl]-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)—N-isobutyl-4-(2-methylbenzyl)-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)—N-isobutyl-4-(pyrazolo[1,5-a]pyridin-7-ylmethyl)-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

(2R)-4-benzyl-N-isobutyl-N-(quinolin-6-ylmethyl)morpholine-2-carboxamide;

or a pharmaceutically acceptable salt thereof.

18. A pharmaceutical composition which comprises an inert carrier and a compound of claim 1 or a pharmaceutically acceptable salt thereof.

19. A method for treating a syndrome or disorder selected from: non-24-hour sleep-wake syndrome; rapid time-zone change syndrome; work-shift syndrome; delayed phase sleep syndrome; advanced sleep phase syndrome; irregular sleep-wake pattern syndrome; syndrome associated with decreased amplitude; seasonal affective disorder; and a condition due to a drug which cause reductions in REM sleep as a side effect, in a mammalian patient in need thereof which comprises administering to the patient a therapeutically effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof.