Process for producing tablet by high-speed direct compression
A process for producing a tablet characterized by performing high-speed direct compression with a moving speed of a pestle of 800 mm/s or more while compressing a powder which contains at least 15 to 80% by mass of cellulose, an active ingredient and a lubricant and has an angle of repose of 50° C. or less, a compression degree of 20% or more and an elongation at break of 30 μm or more.
1. A process for producing a tablet, characterized by comprising performing high-speed direct compression at a punch moving speed of 800 mm/s or more; while compacting a powder which comprises at least 15 to 80% by mass of cellulose, an active ingredient, and a lubricant and has an angle of repose of 50° or less, a compressibility of 20% or more, and a tensile elongation at break of 30 μm or more, wherein said powder is prepared without a fluidizer.
2. The process according to claim 1 , wherein the cellulose is crystalline cellulose of which an average degree of polymerization is 150 to 450, a rate of particles remaining on a sieve of 250 μm in mesh size is 10% by mass or less, average L/D of particles of 75 μm or smaller is 2.0 or more, a bulk density is 0.25 g/cm 3 or less, and an angle of repose is 43° or more.
3. The process according to claim 1 , wherein the powder requires flow energy of 400 mJ or less during aeration.
4. The process according to claim 3 , wherein the powder requires flow energy of 350 mJ or less during aeration.
5. The process according to claim 1 , wherein the powder has an angle of repose of 30 to 50°.
6. The process according to claim 1 , wherein the powder has a compressibility of 20 to 50%.
7. The process according to claim 1 , wherein the powder has a tensile elongation at break of 100 μm or less.
8. The process according to claim 3 , wherein the powder requires flow energy of 100 mJ or more during aeration.
9. The process according to claim 1 , wherein the compaction is performed with a stirring feeder attached to a tablet machine.
10. The process according to claim 2 , wherein the powder requires flow energy of 400 mJ or less during aeration.
11. The process according to claim 10 , wherein the powder requires flow energy of 350 mJ or less during aeration.
12. The process according to claim 2 , wherein the powder has an angle of repose of 30 to 50°.
13. The process according to claim 2 , wherein the powder has a compressibility of 20 to 50%.
14. The process according to claim 2 , wherein the powder has a tensile elongation at break of 100 μm or less.
15. The process according to claim 11 , wherein the powder requires flow energy of 100 mJ or more during aeration.
16. The process according to claim 10 , wherein the compaction is performed with a stirring feeder attached to a tablet machine.