IP Library › Patent Application 12089592
Patent Application
App. No. 12/089,592

Pegylated glutenase polypeptides

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Quick Facts
Patent No.
US None
App. No.
12/089,592
Abstract

Glutenase proteins, such as prolyl endopeptidases, are stabilized by covalent PEG modification.

Claims (10)

1 . An isolated, biologically active glutenase conjugated to at least one polyethylene glycol (PEG) moiety.

2 . The isolated, biologically active glutenase of claim 1 that is a prolyl endopeptidase conjugated to at least one polyethylene glycol (PEG) moiety.

3 . The prolyl endopeptidase of claim 2 , wherein said PEG moiety is at least 2000 Da.

4 . The prolyl endopeptidase of claim 2 , wherein said PEG moiety is at least 5000 Da.

5 . The prolyl endopeptidase of claim 4 , wherein said said prolyl endopeptidase is Flavobacterium meningosepticum PEP; Myxococcus xanthus PEP; Sphingomonas capsulata PEP; Lactobacillus helveticus PEP; Aspergillus niger PEP or Penicillium citrinum PEP.

6 . A pharmaceutical formulation, comprising: an effective dose of the prolyl endopeptidase of claim 1 ; and a pharmaceutically acceptable excipient.

7 . The formulation according to claim 6 , wherein said formulation is suitable for oral administration.

8 . The formulation according to claim 6 , wherein said formulation comprises an enteric coating.

9 . A method of treating Celiac Sprue and/or dermatitis herpetiformis, the method comprising:

administering to a patient an effective dose of a glutenase according to claim 1 ; wherein said glutenase attenuates gluten toxicity in said patient.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 30, 2016
From: ALVINE PHARMACEUTICALS, INC.
To: IMMUNOGENICS LLC
Reel/Frame 039060/0975 →