IP Library › Granted Patent US 7,871,776
Granted Patent B2
US 7,871,776 · App. 12/090,101 · Granted Jan 18, 2011

Compositions and methods for enhancing the identification of prior protein PrP

Assignee: Trustees of Dartmouth College
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Quick Facts
Patent No.
US 7,871,776
App. No.
12/090,101
Granted
Jan 18, 2011
Kind
B2
Abstract

A method for purifying PrP c , a purified preparation of PrP c and methods and kits for identifying the presence of PrP c are provided.

Claims (5)

1. A method for identifying the presence of PrP sc comprising

(a) contacting a sample suspected of containing an infectious prion protein with

(i) a substantially purified preparation of PrP c obtained by immunoaffinity chromatography and ion exchange chromatography, wherein the substantially purified preparation is a preparation that comprises at least 95% PrP c , and

(ii) a nucleic acid molecule which enhances the amplification of PrP sc , wherein said nucleic acid molecule comprises at least 300 bases; and

(b) identifying the presence of PrP sc .

Assignments (2)
CONFIRMATORY LICENSE Recorded Jul 24, 2020
From: DARTMOUTH COLLEGE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 053310/0838 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 15, 2008
From: SUPATTAPONE, SURACHAI; DELEAULT, NATHAN
To: TRUSTEES OF DARTMOUTH COLLEGE
Reel/Frame 020802/0266 →
Continuity (1)
Related Publication 20080261316A1 · Oct 23, 2008