Methods and Compositions For Treating Sleep-Related Breathing Disorders
Provided herein are methods of treating a sleep-related breathing disorder, such as obstructive sleep apnea, comprising the administration of O-desmethylvenlafaxine or duloxetine.
1 . A method of treating a sleep-related breathing disorder in a patient, comprising administering to a patient a therapeutically effective amount of O-desmethylvenlafaxine, or a pharmaceutically acceptable salt or solvate thereof.
2 . The method of claim 1 , wherein the O-desmethylvenlafaxine is enriched for the (+) enantiomer.
3 . The method of claim 2 , wherein the O-desmethylvenlafaxine is enriched for the (−) enantiomer.
4 . The method of claim 3 , wherein the O-desmethylvenlafaxine is substantially free of (+)-O-desmethylvenlafaxine.
5 . The method of claim 1 , wherein the O-desmethylvenlafaxine is administered conjointly with a second active agent, wherein said second active agent is a sleep enhancer, an agent that treats excessive daytime drowsiness, an anti-obesity agent, or an agent that stabilizes respiratory drive.
6 . The method of claim 1 , wherein the O-desmethylvenlafaxine is administered conjointly with positive airway pressure treatment.
7 . The method of claim 1 , wherein the O-desmethylvenlafaxine is administered orally, sublingually, or by oral inhalation.
8 . A method of treating a sleep-related breathing disorder in a patient, comprising administering to a patient a therapeutically effective amount of duloxetine, or a pharmaceutically acceptable salt or solvate thereof.
9 . The method of claim 8 , wherein the duloxetine is administered conjointly with a second active agent, wherein said second active agent is a sleep enhancer, an agent that treats excessive daytime drowsiness, an anti-obesity agent, or an agent that stabilizes respiratory drive.
10 . The method of claim 8 , wherein the duloxetine is administered conjointly with positive airway pressure treatment.
11 . The method of claim 8 , wherein the duloxetine is administered orally, sublingually, or by oral inhalation.
12 . The method of claim 8 , wherein the sleep-related breathing disorder is obstructive sleep apnea.