Method for inhibiting scavenger receptor-A and increasing immune response to antigens
Provided is a method for enhancing an immune response to a desired antigen in an individual. The method is performed by administering to the individual an agent capable of inhibiting class A macrophage scavenger receptor (SR-A) and optionally administering the desired antigen. Also provided is a method for enhancing an immune response to an antigen by administering to an individual a composition containing antigen presenting cells that are characterized by specifically inhibited SR-A. Substantially purified populations of mammalian dendritic cells characterized by specifically inhibited SR-A are also provided.
1. A method for enhancing in an individual an immune response to a desired antigen comprising administering to the individual an effective amount of a composition comprising dendritic cells, wherein the dendritic cells are characterized by having specifically inhibited class A macrophage scavenger receptor (SR-A), wherein the SR-A activity of the dendritic cells is specifically inhibited by an shRNA that is targeted to SR-A mRNA, and wherein the administering the composition enhances the immune response to the desired antigen in the individual.
2. The method of claim 1 , wherein the dendritic cells have been exposed to the desired antigen prior to administration to the individual.
3. The method of claim 1 , wherein the individual has been diagnosed with a tumor which expresses the desired antigen, and wherein the growth of the tumor is inhibited subsequent to administering the composition comprising the dendritic cells.
4. The method of claim 1 , wherein the dendritic cells are isolated from the individual and are exposed to the desired antigen after isolation but prior to administering the composition to the individual.