Granted Patent
B2
US 7,959,916 · App. 12/108,069 · Granted Jun 14, 2011
Negative immunomodulation of immune responses by ERp5
Assignee:
Fred Hutchinson Cancer Research Center
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Abstract
The present invention relates to methods of treating immune disorders and cancers. In particular the invention provides methods of inhibiting the negative immunomodulatory effects of ERp-5 on T cells and dendritic cells, in conjunction with other surface receptors.
Claims (4)
1. A method of inhibiting shedding of MIC polypeptides from a MIC expressing cancer cell comprising contacting a MIC expressing cancer cell with an anti-MIC α3 domain antibody.
2. The method of claim 1 , wherein said MIC is MICA.
3. The method of claim 1 , wherein said MIC is MICB.
4. The method of claim 1 , wherein said anti-MIC antibody is a bi-specific antibody comprising at least one binding region that is specific for surface-bound MIC.
Assignments (5)
CORRECTIVE ASSIGNMENT TO CORRECT THE PATENT APPLICATION NUMBER 63/242,906 PREVIOUSLY RECORDED ON REEL 060439 FRAME 0279. ASSIGNOR(S) HEREBY CONFIRMS THE MERGER AND CHANGE OF NAME.
Recorded Nov 4, 2022
From: FRED HUTCHINSON CANCER RESEARCH CENTER; SEATTLE CANCER CARE ALLIANCE
To: FRED HUTCHINSON CANCER CENTER
Reel/Frame 061847/0594 →
MERGER AND CHANGE OF NAME
Recorded Jun 23, 2022
From: FRED HUTCHINSON CANCER RESEARCH CENTER; SEATTLE CANCER CARE ALLIANCE
To: FRED HUTCHINSON CANCER CENTER
Reel/Frame 060439/0279 →
CONFIRMATORY LICENSE
Recorded Oct 24, 2016
From: FRED HUTCHINSON CANCER RESEARCH CENTER
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 040259/0933 →
CONFIRMATORY LICENSE
Recorded Oct 1, 2009
From: FRED HUTCHINSON CANCER RESEARCH CENTE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 023310/0330 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 23, 2008
From: SPIES, THOMAS; GROH-SPIES, VERONIKA
To: FRED HUTCHINSON CANCER RESEARCH CENTER
Reel/Frame 021136/0290 →
Continuity (2)
Provisional Application
60913467
· Apr 23, 2007