ALLOGENEIC STEM CELL BANK
This invention provides methods for supplying a therapy for individuals exposed to radiation following a nuclear event, through the prospective establishment of an undesignated allogeneic stem cell bank with prospective HLA typing of healthy potential recipients.
1 . A method for providing a hematopoietic stem cell unit in a racially diverse allogeneic stem cell bank for a potential recipient, said method comprising:
(i) providing a plurality of stem cell units having been typed to form an allogeneic stem cell bank having a plurality of typed stem cell units;
(ii) providing a record for each of said plurality of typed stem cell units;
(iii) providing typing for a potential recipient, said potential recipient having a type identifier;
(iv) storing said record for each of said plurality of typed stem cell units and said type identifier in a database;
(v) comparing said type identifier with said record for each of said plurality of typed stem cell units to find a matched stem cell unit; and
(vi) storing said matched stem cell unit in said allogeneic stem cell bank for said potential recipient's use, thereby providing said stem cell unit for said potential recipient.
2 . The method of claim 1 , wherein said potential recipient is a plurality of recipients.
3 . The method of claim 2 , wherein said plurality of typed stem cell units has not been exposed to a lethal dose of radiation.
4 . The method of claim 1 , wherein said hematopoietic stem cell unit is obtained from bone marrow.
5 . The method of claim 1 , wherein said hematopoietic stem cell unit is obtained from peripheral blood.
6 . The method of claim 1 , wherein said hematopoietic stem cell unit is obtained from umbilical cord blood.
7 . The method of claim 1 , wherein said hematopoietic stem cell unit is obtained from placental blood.
8 . The method of claim 1 , wherein said each of said plurality of stem cell units are cryogenically preserved.
9 . The method of claim 1 , wherein the type identifier of said potential recipient is 90%, 80%, 70%, 60%, or 40% similar to said matched stem cell unit.