Diacylglycerol acyltransferase inhibitors

1. A compound of formula (I):

wherein:

R 1 is phenyl or 5- or 6-membered heteroaryl, said phenyl and heteroaryl being unsubstituted or substituted with halogen, lower alkyl, alkoxy or O—CF 3 ;

R 2 is halogen, haloloweralkyl or alkoxy;

R 3 is hydroxy,

amine,

lower alkyl amine,

haloloweralkyl,

lower alkoxy,

lower alkenyloxy,

cycloloweralkyl, unsubstituted or substituted with one to four substituents from lower alkyl, hydroxy, halogen, —C(O)OH, —C(O)O-lower alkyl or —C(O)O-lower alkyl-phenyl,

5- or 6-membered heterocycloalkyl, unsubstituted or substituted, with one to four substituents from lower alkyl, hydroxy, halogen, —SO 2 -loweralkyl, —C(O)OH, —C(O)O-lower alkyl or —C(O)O-lower alkyl-phenyl,

6-membered aryl, unsubstituted or substituted with one to four substituents from lower alkyl, hydroxy, halogen, —C(O)OH, —C(O)O-lower alkyl or —C(O)O-lower alkyl-phenyl,

5- or 6-membered heteroaryl, unsubstituted or substituted with one to four substituents from lower alkyl, hydroxy, halogen, —C(O)OH, C(O)O-lower alkyl or —C(O)O-lower alkyl-phenyl,

(CH 2 ) n C(O)OH,

CH 2 C(lower alkyl) 2 C(O)OH,

CH 2 (cycloalkyl)C(O)OH,

(cycloalkyl)C(O)OH,

CH 2 C(CH 3 ) 3 ,

(CH 2 ) n -cycloalkyl,

cycloalkenyl,

bicycloalkenyl-C(O)OH,

O—C(═C)-lower alkyl,

O—(CH 2 ) n -phenyl,

NSO 2 -loweralkyl,

NSO 2 -cycloalkyl,

NSO 2 -aryl,

N-lower alkyl,

N-cycloalkyl, said cycloalkyl being unsubstituted or substituted with —C(O)OH,

N-heterocycloalkyl,

N-aryl,

N—(CH 2 ) n -aryl,

N-heteroaryl, said heteroaryl being unsubstituted or substituted with alkyl,

N—CH(lower alkyl)C(O)OH,

N-(cycloalkyl)C(O)OH,

N—CH(lower alkyl)C(O)O-lower alkyl, or

phenyl—C(O)OH;

X is 6-membered aryl, said aryl being unsubstituted or substituted with lower alkyl, halogen or cyano;

Y is 6-membered heterocycloalkyl, said heterocycloalkyl being unsubstituted or substituted with lower alkyl, halogen or cyano; and

n is 1, 2 or 3,

or pharmaceutically acceptable salts thereof.

2. The compound according to claim 1 , wherein:

R 1 is phenyl, unsubstituted or substituted with halogen, lower alkyl, alkoxy or O—CF 3 ;

R 2 is halogen, haloloweralkyl or alkoxy;

R 3 is hydroxy,

amine,

lower alkyl amine,

haloloweralkyl,

lower alkoxy,

lower alkenyloxy,

cycloloweralkyl, unsubstituted or substituted with one to four substituents from lower alkyl, hydroxy, halogen, —C(O)OH, —C(O)O-lower alkyl or —C(O)O-lower alkyl-phenyl,

5- or 6-membered heterocycloalkyl, unsubstituted or substituted with one to four substituents from lower alkyl, hydroxy, halogen, —SO 2 -loweralkyl, —C(O)OH, —C(O)O-lower alkyl or —C(O)O-lower alkyl-phenyl,

6-membered aryl, unsubstituted or substituted with one to four substituents from lower alkyl, hydroxy, halogen, —C(O)OH, —C(O)O-lower alkyl or —C(O)O-lower, alkyl-phenyl,

5- or 6-membered heteroaryl, unsubstituted or substituted with one to four substituents from lower alkyl, hydroxy, halogen, —C(O)OH, C(O)O-lower alkyl or —C(O)O-lower alkyl-phenyl,

(CH 2 ) n C(O)OH,

CH 2 C(lower alkyl) 2 C(O)OH,

CH 2 (cycloalkyl)C(O)OH,

(cycloalkyl)C(O)OH,

CH 2 C(CH 3 ) 3 ,

(CH 2 ) n -cycloalkyl,

cycloalkenyl,

bicycloalkenyl-C(O)OH,

(CH 2 ) n —O-alkyl,

O—C(═C)-lower alkyl,

O—(CH 2 ) n -phenyl,

NSO 2 -loweralkyl,

NSO 2 -cycloalkyl,

NSO 2 -aryl,

N-lower alkyl,

N-cycloalkyl, said cycloalkyl being unsubstituted or substituted with —C(O)OH,

N-heterocycloalkyl,

N-aryl,

N-(CH 2 ) n -aryl,

N-heteroaryl, said heteroaryl being unsubstituted or substituted with alkyl,

N—CH(lower alkyl)C(O)OH,

N-(cycloalkyl)C(O)OH,

N—CH(lower alkyl)C(O)O-lower alkyl, or

phenyl-C(O)OH;

X is 6-membered aryl, said aryl being unsubstituted or substituted with lower alkyl, halogen or cyano;

Y is 6 membered heterocycloalkyl, said heterocycloalkyl being unsubstituted or substituted with lower alkyl, halogen or cyano; and

n is 1, 2 or 3.

3. The compound according to claim 1 , wherein:

R 1 is 5- or 6-membered heteroaryl unsubstituted or substituted with halogen, lower alkyl, alkoxy or O—CF 3 ;

R 2 is halogen, haloloweralkyl or alkoxy;

R 3 is hydroxy,

amine,

lower alkyl amine,

haloloweralkyl,

lower alkoxy,

lower alkenyloxy,

cycloloweralkyl, unsubstituted or substituted with one to four substituents from lower alkyl, hydroxy, halogen, —C(O)OH, —C(O)O-lower alkyl or —C(O)O-lower alkyl-phenyl,

5- or 6-membered heterocycloalkyl, unsubstituted or substituted, with one to four substituents from lower alkyl, hydroxy, halogen, —SO 2 -loweralkyl, —C(O)OH, —C(O)O-lower alkyl or —C(O)O-lower alkyl-phenyl,

6-membered aryl, unsubstituted or substituted with one to four substituents from lower alkyl, hydroxy, halogen, —C(O)OH, —C(O)O-lower alkyl or —C(O)O-lower alkyl-phenyl,

5- or 6-membered heteroaryl, unsubstituted or substituted with one to four substituents from lower alkyl, hydroxy, halogen, —C(O)OH, C(O)O-lower alkyl or —C(O)O-lower alkyl-phenyl,

(CH 2 ) n C(O)OH,

CH 2 C(lower alkyl) 2 C(O)OH,

CH 2 (cycloalkyl)C(O)OH,

(cycloalkyl)C(O)OH,

CH 2 C(CH 3 ) 3 ,

(CH 2 ) n -cycloalkyl,

cycloalkenyl,

bicycloalkenyl-C(O)OH,

(CH 2 ) n —O-alkyl,

O—C(═C)-lower alkyl,

O—(CH 2 ) n -phenyl,

NSO 2 -loweralkyl,

NSO 2 -cycloalkyl,

NSO 2 -aryl,

N-lower alkyl,

N-cycloalkyl, said cycloalkyl being unsubstituted or substituted with —C(O)OH,

N-heterocycloalkyl,

N-aryl,

N—(CH 2 )n-aryl,

N-heteroaryl, said heteroaryl being unsubstituted or substituted with alkyl,

N—CH(lower alkyl)C(O)OH,

N-(cycloalkyl)C(O)OH,

N—CH(lower alkyl)C(O)O-lower alkyl, or

phenyl-C(O)OH;

X is 6-membered aryl, said aryl being unsubstituted or substituted with lower alkyl, halogen or cyano;

Y is 6-membered heterocycloalkyl, said heterocycloalkyl being unsubstituted or substituted with lower alkyl, halogen or cyano; and

n is 1, 2 or 3.

4. The compound according to claim 1 , wherein R 1 is phenyl, unsubstituted or substituted with halogen.

5. The compound according to claim 1 , wherein R 1 is pyridine, unsubstituted or substituted with halogen.

6. The compound according to claim 1 , wherein R 2 is halogen, trifluoromethyl, trifluoroethyl, methoxymethyl or methoxyethyl.

7. The compound according to claim 1 , wherein R 3 is lower alkyl amine; cycloloweralkyl, unsubstituted or substituted with one to four substituents from loweralkyl, hydroxy, halogen, —C(O)OH, —C(O)O-lower alkyl or —C(O)O-lower alkyl-phenyl; 5- or 6-membered heterocycloalkyl, unsubstituted or substituted, with one to four substituents from lower alkyl, hydroxy, halogen, —SO 2 -loweralkyl, —C(O)OH, —C(O)O-lower alkyl or —C(O)O-lower alkyl-phenyl; (CH 2 ) n C(O)OH; CH 2 C(lower alkyl) 2 C(O)OH; CH 2 (cycloalkyl)C(O)OH; (cycloalkyl)C(O)OH; NSO 2 -loweralkyl; N-lower alkyl; N-cycloalkyl, said cycloalkyl being unsubstituted or substituted with —C(O)OH; N—CH(lower alkyl)C(O)OH; or —N-(cycloalkyl)C(O)OH.

8. The compound according to claim 1 , wherein Y is piperazine or piperidine.

9. The compound according to claim 1 , selected from the group consisting of:

2,2-Dimethyl-4-oxo-4-(4-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperazin-1-yl)-butyric acid,

trans-4-(4-{4-[(2-Phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperazine-1-carbonyl)-cyclohexanecarboxylic acid,

(1R,2R)-2-(4-{4-[(2-Phenyl-5-trifluoromethyl -oxazole-4-carbonyl)-amino]-phenyl}-piperidine-1-carbonyl)-cyclopentanecarboxylic acid,

trans-4-(4-{4-[(2-Phenyl-5-tiifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperidine-1-carbonyl)-cyclohexanecarboxylic acid,

cis-4-(4-{4-[(2-Phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperidine-1-carbonyl)-cyclohexanecarboxylic acid,

(1R,2R)-2-(4-{4-[(2-Phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino] -phenyl}-piperazine-1-carbonyl)-cyclopentanecarboxylic acid,

cis-4-(4-{4-[(2-Phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperazine-1-carbonyl)-cyclohexanecarboxylic acid,

(1R,3S)-3-(4-{4-[(2-Phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperazine-1-carbonyl)-cyclohexanecarboxylic acid,

2-Phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid {4-[4-(2-methyl-propane-2-sulfonylamino carbonyl)-piperidin-1-yl]-phenyl}-amide.

10. A compound of the formula:

wherein:

R 2 is halogen, haloloweralkyl or alkoxy;

R 3 ′ is cycloloweralkyl or a 5 or 6 membered heterocycloalkyl, wherein the cycloloweralkyl or heterocycloalkyl can be unsubstituted or substituted with one substituent selected from lower alkyl, hydroxy, halogen, —C(O)OH, —C(O)O-lower alkyl or —C(O)O-lower alkyl-phenyl, and

Y′ is 6 membered heterocycloalkyl, said heterocycloalkyl being unsubstituted or substituted with lower alkyl, halogen or cyano;

or pharmaceutically acceptable salts thereof.

11. The compound of claim 10 wherein R 2 is halo lower alkyl.

12. The compound of claim 11 wherein R 3 ′ a substituted or unsubstituted 5 or 6 membered heterocycloalkyl wherein the cycloalkyl has one or two of its ring carbon atoms replaced by a nitrogen atom.

13. The compound of claim 11 wherein R 3 ′ is a substituted or unsubstituted cycloalkyl ring containing from 4 to 7 ring carbon atoms or its pharmaceutically acceptable salts.

14. The compound of claim 13 wherein said compound is 2-(4-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperazine-1-carbonyl)-cyclopentanecarboxylic acid or its pharmaceutically acceptable salts.

15. The compound of claim 13 wherein said compound is 2-(4-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperadine-1-carbonyl)-cyclopentanecarboxylic acid or its pharmaceutically acceptable salts.

16. The compound of claim 12 wherein said compound is 1-(4-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperidine-1-carbonyl)-piperidin-4- yl]-acetic acid or its pharmaceutically acceptable salts.

17. The compound of claim 14 wherein said compound is ((1R,2R)-2-(4-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperazine-1-carbonyl)-cyclopentanecarboxylic acid or its pharmaceutically acceptable salts.

18. The compound of claim 15 wherein said compound is ((1R,2R)-2-(4-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperadine-1-carbonyl)-cyclopentanecarboxylic acid or its pharmaceutically acceptable salts.