Diacylglycerol acyltransferase inhibitors

1. A compound of formula (I):

wherein:

R 1 is phenyl unsubstituted or substituted with halogen, lower alkyl, alkoxy or O—CF 3 ;

R 2 is N;

R 3 is N;

R 4 is C;

R 5 is CH;

R 6 is halogen, lower alkyl, haloloweralkyl or alkoxy;

R 7 is NR a , O or absent, wherein R a is H or lower alkyl;

R 8 is CR b R c , NR b , O or absent, wherein each of R b and R c , independently, is H or lower alkyl; wherein both R 7 and R 8 are not absent;

R 9 is

-lower alkyl,

-alkoxy,

-hydroxy,

-amine,

-lower alkyl amine,

-haloloweralkyl,

-lower alkoxy,

-lower alkenyloxy,

-cycloloweralkyl, unsubstituted or substituted with one to four substituents selected from lower alkyl, hydroxy, halogen, —C(O)OH, —C(O)O-lower alkyl and —C(O)O-lower alkyl-phenyl,

-5- or 6-membered heterocycloalkyl, unsubstituted or substituted, with one to four substituents selected from lower alkyl, hydroxy, halogen, —SO 2 -loweralkyl, —C(O)OH, —C(O)O-lower alkyl and —C(O)O-lower alkyl-phenyl,

-6-membered aryl, unsubstituted or substituted with one to four substituents selected from lower alkyl, hydroxy, halogen, —C(O)OH, —C(O)O-lower alkyl and —C(O)O-lower alkyl-phenyl,

-5- or 6-membered heteroaryl, unsubstituted or substituted with one to four substituents selected from lower alkyl, hydroxy, halogen, —C(O)OH, C(O)O-lower alkyl and —C(O)O-lower alkyl-phenyl,

—(CH 2 ) n C(O)OH,

—CH 2 C(lower alkyl) 2 C(O)OH,

—CH 2 (cycloalkyl)C(O)OH,

-(cycloalkyl)C(O)OH,

—CH 2 C(CH 3 ) 3 ,

—(CH 2 ) n -cycloalkyl,

-cycloalkenyl,

-bicycloalkenyl-C(O)OH,

—(CH 2 ) n —O-alkyl,

—O—C(═C)-lower alkyl,

—O—(CH 2 ) n -phenyl,

—NSO 2 -loweralkyl,

—NSO 2 -cycloalkyl,

—NSO 2 -aryl,

—N-lower alkyl,

—N-cycloalkyl, said cycloalkyl being unsubstituted or substituted with —C(O)OH,

—N-heterocycloalkyl,

—N-aryl,

—N—(CH 2 ) n -aryl,

—N-heteroaryl, said heteroaryl being unsubstituted or substituted with alkyl,

—N—CH(lower alkyl)C(O)OH,

—N-(cycloalkyl)C(O)OH,

—N—CH(lower alkyl)C(O)O-lower alkyl, or

-phenyl-C(O)OH,

X is 6-membered aryl or 5- or 6-membered heteroaryl, said aryl or heteroaryl being unsubstituted or substituted with lower alkyl, halogen or cyano;

Y is phenyl, heteroaryl, cycloloweralkyl, or 5- or 6-membered heterocycloalkyl, said phenyl, cycloloweralkyl or heterocycloalkyl being unsubstituted or substituted with lower alkyl, halogen or cyano; and

n is 1, 2 or 3,

or pharmaceutically acceptable salts thereof.

2. The compound according to claim 1 , wherein:

R 1 is phenyl unsubstituted or substituted with halogen, lower alkyl, alkoxy or O—CF 3 ;

R 2 is N;

R 3 is N;

R 4 is C;

R 5 is CH;

R 6 is halogen, lower alkyl, haloloweralkyl or alkoxy;

R 7 is NR a , O or absent, wherein R a is H or lower alkyl;

R 8 is CR b R c , NR b , O or absent, wherein each of R b and R c , independently, is H or lower alkyl; wherein both R 7 and R 8 are not absent;

R 9 is

-lower alkyl,

-alkoxy,

-hydroxy,

-amine,

-lower alkyl amine,

-haloloweralkyl,

-lower alkoxy,

-lower alkenyloxy,

-cycloloweralkyl, unsubstituted or substituted with one to four substituents selected from lower alkyl, hydroxy, halogen, —C(O)OH, —C(O)O-lower alkyl and —C(O)O-lower alkyl-phenyl,

-5- or 6-membered heterocycloalkyl, unsubstituted or substituted, with one to four substituents selected from lower alkyl, hydroxy, halogen, —SO 2 -loweralkyl, —C(O)OH, —C(O)O-lower alkyl and —C(O)O-lower alkyl-phenyl,

-6-membered aryl, unsubstituted or substituted with one to four substituents selected from lower alkyl, hydroxy, halogen, —C(O)OH, —C(O)O-lower alkyl and —C(O)O-lower alkyl-phenyl,

-5- or 6-membered heteroaryl, unsubstituted or substituted with one to four substituents selected from lower alkyl, hydroxy, halogen, —C(O)OH, C(O)O-lower alkyl and —C(O)O-lower alkyl-phenyl,

—(CH 2 ) n C(O)OH,

—CH 2 C(lower alkyl) 2 C(O)OH,

—CH 2 (cycloalkyl)C(O)OH,

-(cycloalkyl)C(O)OH,

—CH 2 C(CH 3 ) 3 ,

—(CH 2 ) n -cycloalkyl,

-cycloalkenyl,

-bicycloalkenyl-C(O)OH,

—O—C(═C)-lower alkyl,

—O—(CH 2 ) n -phenyl,

—NSO 2 -loweralkyl,

—NSO 2 -cycloalkyl,

—NSO 2 -aryl,

—N-lower alkyl,

—N-cycloalkyl, said cycloalkyl being unsubstituted or substituted with —C(O)OH,

—N-heterocycloalkyl,

—N-aryl,

—N—(CH 2 ) n -aryl,

—N-heteroaryl, said heteroaryl being unsubstituted or substituted with alkyl,

—N—CH(lower alkyl)C(O)OH,

—N-(cycloalkyl)C(O)OH,

—N—CH(lower alkyl)C(O)O-lower alkyl, or

-phenyl-C(O)OH,

X is 6-membered aryl, unsubstituted or substituted with lower alkyl, halogen or cyano;

Y is phenyl, heteroaryl, cycloloweralkyl, or 5- or 6-membered heterocycloalkyl, said phenyl, cycloloweralkyl or heterocycloalkyl being unsubstituted or substituted with lower alkyl, halogen or cyano; and

n is 1, 2 or 3.

3. The compound according to claim 1 , wherein:

R 1 is phenyl unsubstituted or substituted with halogen, lower alkyl, alkoxy or O—CF 3 ;

R 2 is N;

R 3 is N;

R 4 is C;

R 5 is CH;

R 6 is halogen, lower alkyl, haloloweralkyl or alkoxy;

R 7 is NR a , O or absent, wherein R a is H or lower alkyl;

R 8 is CR b R c , NR b , O or absent, wherein each of R b and R c , independently, is H or lower alkyl; wherein both R 7 and R 8 are not absent;

R 9 is

-lower alkyl,

-alkoxy,

-hydroxy,

-amine,

-lower alkyl amine,

-haloloweralkyl,

-lower alkoxy,

-lower alkenyloxy,

-cycloloweralkyl, unsubstituted or substituted with one to four substituents selected from lower alkyl, hydroxy, halogen, —C(O)OH, —C(O)O-lower alkyl and —C(O)O-lower alkyl-phenyl,

-5- or 6-membered heterocycloalkyl, unsubstituted or substituted, with one to four substituents selected from lower alkyl, hydroxy, halogen, —SO 2 -loweralkyl, —C(O)OH, —C(O)O-lower alkyl and —C(O)O-lower alkyl-phenyl,

-6-membered aryl, unsubstituted or substituted with one to four substituents selected from lower alkyl, hydroxy, halogen, —C(O)OH, —C(O)O-lower alkyl and —C(O)O-lower alkyl-phenyl,

-5- or 6-membered heteroaryl, unsubstituted or substituted with one to four substituents selected from lower alkyl, hydroxy, halogen, —C(O)OH, C(O)O-lower alkyl and —C(O)O-lower alkyl-phenyl,

—(CH 2 ) n C(O)OH,

—CH 2 C(lower alkyl) 2 C(O)OH,

—CH 2 (cycloalkyl)C(O)OH,

-(cycloalkyl)C(O)OH,

—CH 2 C(CH 3 ) 3 ,

—(CH 2 ) n -cycloalkyl,

-cycloalkenyl,

-bicycloalkenyl-C(O)OH,

—(CH 2 ) n —O-alkyl,

—O—C(═C)-lower alkyl,

—O—(CH 2 ) n -phenyl,

—NSO 2 -loweralkyl,

—NSO 2 -cycloalkyl,

—NSO 2 -aryl,

—N-lower alkyl,

—N-cycloalkyl, said cycloalkyl being unsubstituted or substituted with —C(O)OH,

—N-heterocycloalkyl,

—N-aryl,

—N—(CH 2 ) n -aryl,

—N-heteroaryl, said heteroaryl being unsubstituted or substituted with alkyl,

—N—CH(lower alkyl)C(O)OH,

—N-(cycloalkyl)C(O)OH,

—N—CH(lower alkyl)C(O)O-lower alkyl, or

-phenyl-C(O)OH,

X is 5- or 6-membered heteroaryl, unsubstituted or substituted with lower alkyl, halogen or cyano;

Y is phenyl, heteroaryl, cycloloweralkyl, or 5- or 6-membered heterocycloalkyl, said phenyl, cycloloweralkyl or heterocycloalkyl being unsubstituted or substituted with lower alkyl, halogen or cyano; and

n is 1, 2 or 3.

4. The compound according to claim 1 , wherein:

R 1 is phenyl, unsubstituted or substituted with halogen, lower alkyl, alkoxy or O—CF 3 ;

R 2 is N;

R 3 is N;

R 4 is C;

R 5 is CH;

R 6 is halogen, lower alkyl, haloloweralkyl or alkoxy;

R 7 is NR a , O or absent, wherein R a is H or lower alkyl;

R 8 is CR b R c , NR b , O or absent, wherein each of R b and R c , independently, is H or lower alkyl; wherein both R 7 and R 8 are not absent;

R 9 is

-lower alkyl,

-alkoxy,

-hydroxy,

-amine,

-lower alkyl amine,

-haloloweralkyl,

-lower alkoxy,

-lower alkenyloxy,

-cycloloweralkyl, unsubstituted or substituted with one to four substituents selected from lower alkyl, hydroxy, halogen, —C(O)OH, —C(O)O-lower alkyl and —C(O)O-lower alkyl-phenyl,

-5- or 6-membered heterocycloalkyl, unsubstituted or substituted, with one to four substituents selected from lower alkyl, hydroxy, halogen, —SO 2 -loweralkyl, —C(O)OH, —C(O)O-lower alkyl and —C(O)O-lower alkyl-phenyl,

-6-membered aryl, unsubstituted or substituted with one to four substituents selected from lower alkyl, hydroxy, halogen, —C(O)OH, —C(O)O-lower alkyl and —C(O)O-lower alkyl-phenyl,

-5- or 6-membered heteroaryl, unsubstituted or substituted with one to four substituents selected from lower alkyl, hydroxy, halogen, —C(O)OH, C(O)O-lower alkyl and —C(O)O-lower alkyl-phenyl,

—(CH 2 ) n C(O)OH,

—CH 2 C(lower alkyl) 2 C(O)OH,

—CH 2 (cycloalkyl)C(O)OH,

-(cycloalkyl)C(O)OH,

—CH 2 C(CH 3 ) 3 ,

—(CH 2 ) n -cycloalkyl,

-cycloalkenyl,

-bicycloalkenyl-C(O)OH,

—(CH 2 ) n —O-alkyl,

—O—C(═C)-lower alkyl,

—O—(CH 2 ) n -phenyl,

—NSO 2 -loweralkyl,

—NSO 2 -cycloalkyl,

—NSO 2 -aryl,

—N-lower alkyl,

—N-cycloalkyl, said cycloalkyl being unsubstituted or substituted with —C(O)OH,

—N-heterocycloalkyl,

—N-aryl,

—N—(CH 2 ) n -aryl,

—N-heteroaryl, said heteroaryl being unsubstituted or substituted with alkyl,

—N—CH(lower alkyl)C(O)OH,

—N-(cycloalkyl)C(O)OH,

—N—CH(lower alkyl)C(O)O-lower alkyl, or

-phenyl-C(O)OH,

X is 6-membered aryl or 5- or 6-membered heteroaryl, said aryl or heteroaryl being unsubstituted or substituted with lower alkyl, halogen or cyano;

Y is phenyl, unsubstituted or substituted with lower alkyl, halogen or cyano; and

n is 1, 2 or 3.

5. The compound according to claim 1 , wherein:

R 1 is phenyl unsubstituted or substituted with halogen, lower alkyl, alkoxy or O—CF 3 ;

R 2 is N;

R 3 is N;

R 4 is C;

R 5 is CH;

R 6 is halogen, lower alkyl, haloloweralkyl or alkoxy;

R 7 is NR a , O or absent, wherein R a is H or lower alkyl;

R 8 is CR b R c , NR b , O or absent, wherein each of R b and R c , independently, is H or lower alkyl; wherein both R 7 and R 8 are not absent;

R 9 is

-lower alkyl,

-alkoxy,

-hydroxy,

-amine,

-lower alkyl amine,

-haloloweralkyl,

-lower alkoxy,

-lower alkenyloxy,

-cycloloweralkyl, unsubstituted or substituted with one to four substituents selected from lower alkyl, hydroxy, halogen, —C(O)OH, —C(O)O-lower alkyl and —C(O)O-lower alkyl-phenyl,

-5- or 6-membered heterocycloalkyl, unsubstituted or substituted, with one to four substituents selected from lower alkyl, hydroxy, halogen, —SO 2 -loweralkyl, —C(O)OH, —C(O)O-lower alkyl and —C(O)O-lower alkyl-phenyl,

-6-membered aryl, unsubstituted or substituted with one to four substituents selected from lower alkyl, hydroxy, halogen, —C(O)OH, —C(O)O-lower alkyl and —C(O)O-lower alkyl-phenyl,

-5- or 6-membered heteroaryl, unsubstituted or substituted with one to four substituents selected from lower alkyl, hydroxy, halogen, —C(O)OH, C(O)O-lower alkyl and —C(O)O-lower alkyl-phenyl,

—(CH 2 ) n C(O)OH,

—CH 2 C(lower alkyl) 2 C(O)OH,

—CH 2 (cycloalkyl)C(O)OH,

-(cycloalkyl)C(O)OH,

—CH 2 C(CH 3 ) 3 ,

—(CH 2 ) n -cycloalkyl,

-cycloalkenyl,

-bicycloalkenyl-C(O)OH,

—(CH 2 ) n —O-alkyl,

—O—C(═C)-lower alkyl,

—O—(CH 2 ) n -phenyl,

—NSO 2 -loweralkyl,

—NSO 2 -cycloalkyl,

—NSO 2 -aryl,

—N-lower alkyl,

—N-cycloalkyl, said cycloalkyl being unsubstituted or substituted with —C(O)OH,

—N-heterocycloalkyl,

—N-aryl,

—N—(CH 2 ) n -aryl,

—N-heteroaryl, said heteroaryl being unsubstituted or substituted with alkyl,

—N—CH(lower alkyl)C(O)OH,

—N-(cycloalkyl)C(O)OH,

—N—CH(lower alkyl)C(O)O-lower alkyl, or

-phenyl-C(O)OH,

X is 6-membered aryl or 5- or 6-membered heteroaryl, said aryl or heteroaryl being unsubstituted or substituted with lower alkyl, halogen or cyano;

Y is cycloloweralkyl or 5- or 6-membered heterocycloalkyl, said cycloloweralkyl or heterocycloalkyl being unsubstituted or substituted with lower alkyl, halogen or cyano; and

n is 1, 2 or 3.

6. The compound according to claim 1 , wherein:

R 1 is phenyl, unsubstituted or substituted with halogen, lower alkyl, alkoxy or O—CF 3 ; and

X is 6-membered aryl, unsubstituted or substituted with lower alkyl, halogen or cyano.

7. The compound according to claim 1 , wherein:

R 1 is phenyl, unsubstituted or substituted with halogen, lower alkyl, alkoxy or O—CF 3 ; and

X is 5- or 6-membered heteroaryl, unsubstituted or substituted with lower alkyl, halogen or cyano.

8. The compound according to claim 1 , wherein:

R 1 is phenyl, unsubstituted or substituted with halogen, lower alkyl, alkoxy or O—CF 3 ; and

Y is phenyl, unsubstituted or substituted with lower alkyl, halogen or cyano.

9. The compound according to claim 1 , wherein:

R 1 is phenyl, unsubstituted or substituted with halogen, lower alkyl, alkoxy or O—CF 3 ; and

Y is cycloloweralkyl or 5- or 6-membered heterocycloalkyl, said cycloloweralkyl or heterocycloalkyl being unsubstituted or substituted with lower alkyl, halogen or cyano.

10. The compound according to claim 1 , wherein:

X is 6-membered aryl, unsubstituted or substituted with lower alkyl, halogen or cyano; and

Y is phenyl, heteroaryl, cycloloweralkyl, or 5- or 6-membered heterocycloalkyl, said phenyl, cycloloweralkyl or heterocycloalkyl being unsubstituted or substituted with lower alkyl, halogen or cyano.

11. The compound according to claim 1 , wherein:

X is 5- or 6-membered heteroaryl, unsubstituted or substituted with lower alkyl, halogen or cyano; and

Y is phenyl, heteroaryl, cycloloweralkyl, or 5- or 6-membered heterocycloalkyl, said phenyl, cycloloweralkyl or heterocycloalkyl being unsubstituted or substituted with lower alkyl, halogen or cyano.

12. The compound according to claim 1 , wherein:

X is 6-membered aryl or 5- or 6-membered heteroaryl, said aryl or heteroaryl being unsubstituted or substituted with lower alkyl, halogen or cyano; and

Y is phenyl, unsubstituted or substituted with lower alkyl, halogen or cyano.

13. The compound according to claim 1 , wherein:

X is 6-membered aryl or 5- or 6-membered heteroaryl, said aryl or heteroaryl being unsubstituted or substituted with lower alkyl, halogen or cyano; and

Y is cycloloweralkyl or 5- or 6-membered heterocycloalkyl, said cycloloweralkyl or heterocycloalkyl being unsubstituted or substituted with lower alkyl, halogen or cyano.

14. The compound according to claim 1 , wherein X is phenyl, pyridine or pyrimidine.

15. The compound according to claim 1 , wherein R 6 is halogen, trifluoromethyl, trifluoroethyl, methyl, ethyl, propyl, methoxymethyl or methoxyethyl.

16. The compound according to claim 1 , wherein R 7 is NR a , wherein R a is H or lower alkyl.

17. The compound according to claim 1 , wherein R 8 is NR b , wherein R b is H or lower alkyl.

18. The compound according to claim 1 , wherein R 9 is lower alkyl, alkoxy, hydroxy, lower alkyl amine; cycloloweralkyl, unsubstituted or substituted with one to four substituents from loweralkyl, hydroxy, halogen, —C(O)OH, —C(O)O-lower alkyl or —C(O)O-lower alkyl-phenyl; 5- or 6-membered heterocycloalkyl, unsubstituted or substituted, with one to four substituents from lower alkyl, hydroxy, halogen, —SO2-loweralkyl, —C(O)OH, —C(O)O-lower alkyl or —C(O)O-lower alkyl-phenyl; (CH 2 ) n C(O)OH; CH 2 C(lower alkyl) 2 C(O)OH; CH 2 (cycloalkyl)C(O)OH; (cycloalkyl)C(O)OH; NSO 2 -loweralkyl; N-lower alkyl; N-cycloalkyl, said cycloalkyl being unsubstituted or substituted with —C(O)OH; N—CH(lower alkyl)C(O)OH; or —N-(cycloalkyl)C(O)OH.

19. The compound according to claim 1 , wherein Y is phenyl, pyridine, piperazine, piperidine, pyrrolidine or cyclopentane.

20. A compound selected from the group consisting of:

(S)-3-{5-[(1-Pyridin-2-yl-3-trifluoromethyl-1H-pyrazole-4-carbonyl)-amino]-pyridin-2-ylamino}-pyrrolidine-1-carboxylic acid ethyl ester,

(S)-3-{4-[(1-Phenyl-3-trifluoromethyl-1H-pyrazole-4-carbonyl)-amino]-phenylamino}-pyrrolidine-1-carboxylic acid ethyl ester,

(S)-3-{5-[(1-Phenyl-3-trifluoromethyl-1H-pyrazole-4-carbonyl)-amino]-pyridin-2-ylamino}-pyrrolidine-1-carboxylic acid ethyl ester,

(S)-3-{5-[(4-Methyl-2-pyridin-2-yl-thiazole-5-carbonyl)-amino]-pyridin-2-ylamino}-pyrrolidine-1-carboxylic acid ethyl ester, and

(S)-3-5-[(4-Methyl-2-pyridin-2-yl-thiazole-5-carbonyl)-amino]-pyridin-2-ylamino}-pyrrolidine-1-carboxylic acid tert-butyl ester.

21. A compound of the formula

wherein:

R 1 is a phenyl ring unsubstituted or substituted with halogen, lower alkyl, alkoxy or O—CF 3 ;

R 6 is halogen, lower alkyl, haloloweralkyl or alkoxy;

X is 6-membered aryl or 5- or 6-membered heteroaryl, said aryl or heteroaryl being unsubstituted or substituted with lower alkyl, halogen or cyano;

Y is a phenyl ring, a heteroaryl ring, cycloloweralkyl ring, or 5- or 6-membered heterocycloalkyl ring, said phenyl, cycloloweralkyl or heterocycloalkyl rings being unsubstituted or substituted with lower alkyl, halogen or cyano; and

R 9 is halogen, lower alkyl, haloloweralkyl or alkoxy;

or pharmaceutically acceptable salts thereof.

22. The compound of claim 21 wherein Y is a 5 or 6 heterocycloalkyl ring having one of its ring carbon atoms replaced by a nitrogen atom.

23. A compound selected from 3-{5-[(1-phenyl-3-trifluoromethyl-1H-pyrazole-4-carbonyl)-amino]-pyridin-2-ylamino}-pyrrolidine-1- carboxylic acid ethyl ester, 3-{4-[(1-phenyl-3-trifluoromethyl-1H-pyrazole-4-carbonyl)-amino]-phenylamino}-pyrrolidine-1-carboxylic acid ethyl ester, and their pharmaceutically acceptable salts.