Therapeutic Compounds 570
Compounds of formula I or pharmaceutically acceptable salts thereof: wherein R 1 , R 2 , R 3 , R 4 , and R 5 and are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
1 . A compound of formula I, a pharmaceutically acceptable salt thereof, a diastereomer, an enantiomer, or a mixture thereof:
wherein:
R 1 and R 2 are independently selected from hydrogen, C 1-6 alkyl-C(═O)—, C 1-6 alkyl, C 2-6 alkenyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl-C 1-6 alkyl, C 3-7 cycloalkyl fused with a phenyl, C 3-7 cycloalkyl fused with a phenyl and a C 2-6 heteroaryl, C 6-10 aryl fused with a C 3-7 cycloalkyl, C 1-14 heterocyclyl, C 1-14 heterocyclyl-C 1-6 alkyl, C 6-10 aryl, C 6-10 aryl-C 1-6 alkyl, or R 1 and R 2 together with the nitrogen connected thereto form a C 2-9 heterocyclyl; wherein said C 1-6 alkyl-C(═O)—, C 1-6 alkyl, C 2-6 alkenyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl-C 1-6 alkyl, C 3-7 cycloalkyl fused with a phenyl, C 3-7 cycloalkyl fused with a phenyl and a C 2-6 heteroaryl, C 6-10 aryl fused with a C 3-7 cycloalkyl, C 1-14 heterocyclyl, C 1-14 heterocyclyl-C 1-6 alkyl, C 6-10 aryl, C 6-10 aryl-C 1-6 alkyl and C 2-9 heterocyclyl are optionally substituted by one or more groups selected from, halogen, cyano, nitro, C 1-6 alkoxy, C 1-4 haloalkoxy, C 1-6 alkyl, halogenated C 1-6 alkyl, C 3-6 -cycloalkyl, C 3-6 cycloalkoxy, C 3-6 cycloalkyl-C 1-4 alkoxy, —(CH 2 ) m —C(═O)NR 7 R 8 , —(CH 2 ) m —S(═O) 2 NR 7 R 8 , —(CH 2 ) m NH—C(═O)NR 7 R 8 , —(CH 2 ) m —N(R 7 )C(═O)R 8 , —(CH 2 ) m —N(R 7 )C(═O)—OR 8 , —(CH 2 ) m —C(═O)—OR 7 —(CH 2 ) m —C(═O)R 7 —(CH 2 ) m —S(═O) 2 R 7 , —(CH 2 ) m —S(═O)R 7 —(CH 2 ) m —SR 7 , —(CH 2 ) m —O—C(═O)—R 7 —(CH 2 ) m —OR 7 —(CH 2 ) m —NR 7 R 8 hydroxy, C 1-14 heterocyclyl-C 0-4 -alkyl, phenyl, benzyl, phenylethyl, wherein said C 1-14 heterocyclyl-C 0-4 -alkyl, phenyl, benzyl or phenethyl optionally substituted by one or more groups selected from halogen, cyano, nitro, oxo, C 1-6 alkoxy, C 1-4 haloalkoxy, C 1-6 alkyl, halogenated C 1-6 alkyl, C 3-6 -cycloalkyl, C 3-6 cycloalkoxy, —(CH 2 ) m —C(═O)NR 7 R 8 , —C(═O)—(CH 2 ) m —NR 7 R 8 , —(CH 2 ) m —S(═O) 2 NR 7 R 8 , —(CH 2 ) m NH—C(═O)NR 7 R 8 , —(CH 2 ) m —N(R 7 )C(═O)R 8 , —(CH 2 ) m —N(R 7 )C(═O)—OR 8 , —(CH 2 ) m —C(═O)—OR 7 —(CH 2 ) m —C(═O)R 7 —(CH 2 ) m —S(═O) 2 R 7 —(CH 2 ) m —S(═O)R 7 —(CH 2 ) m —SR 7 —(CH 2 ) m —O—C(═O)—R 7 —(CH 2 ) m —R 7 , —(CH 2 ) m —NR 7 R 8 and hydroxy;
R 3 and R 4 are independently selected from hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl-C 1-6 alkyl, C 6-10 aryl, C 6-10 aryl-C 1-6 alkyl, C 3-6 heterocyclyl, and C 3-6 heterocyclyl-C 1-6 alkyl; or R 3 and R 4 together with the nitrogen connected thereto form a C 2-9 heterocyclyl; wherein said C 1-6 alkyl, C 2-6 alkenyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl-C 1-6 alkyl, C 6-10 aryl, C 6-10 aryl-C 1-6 alkyl, C 3-6 heterocyclyl, C 3-6 heterocyclyl-C 1-6 alkyl and C 2-9 heterocyclyl are optionally substituted by one or more groups selected from C 1-6 alkyl, halogenated C 1-6 alkyl, carboxy, halogen, cyano, nitro, oxo, C 1-4 -alkoxy, C 1-4 haloalkoxy, hydroxy, C 3-6 cycloalkyl-C 1-4 alkoxy, C 3-6 heterocycloalkyl, —(CH 2 ) m —C 3-6 heterocyclyl, —(CH 2 ) m —C(═O)NR 7 R 8 , —C(═O)—(CH 2 ) m —NR 7 R 8 , —(CH 2 ) m —S(═O) 2 NR 7 R 8 , —(CH 2 ) m NH—C(═O)NR 7 R 8 , —(CH 2 ) m —N(R 7 )C(═O)R 8 , —(CH 2 ) m —N(R 7 )C(═O)—OR 8 , —(CH 2 ) m —C(═O)—OR 7 —(CH 2 ) m —C(═O)R 7 —(CH 2 ) m —S(═O) 2 R 7 , —(CH 2 ) m —O—C(═O)—R 7 —(CH 2 ) m —OR 7 and —(CH 2 ) m —NR 7 R 8 ;
R 5 is selected from hydrogen and C 1-6 alkyl, C 3-7 -cycloalkyl, C 1-6 heterocyclyl, and —(CH 2 ) m —C 6-10 aryl, optionally substituted with one or more groups selected from OH, C 1-4 alkoxy, halogenated C 1-4 alkoxy, and halogen;
R 7 and R 8 are independently selected from —H, C 1-6 alkyl, C 6-10 aryl, C 6-10 aryl-C 1-4 alkyl, C 1-5 heterocyclyl, and C 3-6 cycloalkyl-C 0-4 alkyl, wherein said C 1-6 alkyl, C 6-10 aryl, C 6-10 aryl-C 1-4 alkyl, C 1-5 heterocyclyl, and C 3-6 cycloalkyl-C 0-4 alkyl are optionally substituted with one or more groups selected from —OH, C 1-4 alkyl, methoxy, ethoxy and halogen; and
m is 0, 1, 2 or 3,
with a proviso that at least one of R 1 , R 2 , R 3 and R 4 is not hydrogen with a further proviso that the compound is not selected from 5-[2-(4-{4-[(4-chlorophenyl)amino]-6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl}piperazin-1-yl)-2-oxoethyl]imidazolidine-2,4-dione
2-amino-4-anilino-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
1-[4-[(4-chlorophenyl)amino]-6,7-dihydro-6-(1-methylethyl)-7-oxo-5H-pyrrolo[3,4-d]pyrimidin-2-yl]-4-[2-(hydroxyimino)-1-oxopropyl]-piperazine;
4-[(4-chlorophenyl)amino]-5,6-dihydro-2-(4-morpholinyl)-6-[2-(4-morpholinyl)ethyl]-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-[(2-aminophenyl)amino]-5,6-dihydro-5-imino-6-propyl-2-(1-pyrrolidinyl)-7H-pyrrolo[3,4-d]pyrimidin-7-one;
5,6-dihydro-5-imino-6-propyl-4-(propylamino)-2-(1-pyrrolidinyl)-7H-pyrrolo[3,4-d]pyrimidin-7-one;
5-amino-2-(1-piperidinyl)-4-(propylamino)-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4,5-diamino-2-(1-piperidinyl)-7H-Pyrrolo[3,4-d]pyrimidin-7-one;
5-amino-4-(1-piperidinyl)-2-(1-pyrrolidinyl)-7H-pyrrolo[3,4-d]pyrimidin-7-one;
5-amino-4-(propylamino)-2-(1-pyrrolidinyl) 7H-pyrrolo[3,4-d]pyrimidin-7-one;
4,5-diamino-2-(1-pyrrolidinyl)-7H-pyrrolo[3,4-d]pyrimidin-7-one;
N-[6,7-dihydro-7-oxo-6-phenyl-4-(1-piperidinyl)-5H-pyrrolo[3,4-d]pyrimidin-2-yl]-N-phenylbenzamide;
5-[(dimethylamino)methylene]-5,6-dihydro-6-phenyl-2-(phenylamino)-4-(1-piperidinyl)-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2,4-bis(dimethylamino)-5,6-dihydro-6-phenyl-7H-pyrrolo[3,4-d]pyrimidin-7-one;
5,6-dihydro-6-phenyl-2-(phenylamino)-4-(1-piperidinyl)-7H-pyrrolo[3,4-d]pyrimidin-7-one;
5,6-dihydro-6-methyl-2,4-di-1-piperidinyl-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-anilino-6-butyl-2-(butylamino)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-anilino-2-p-anisidino-5,6-dihydro-6-(p-methoxyphenyl)-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-anilino-5,6-dihydro-4-(p-hydroxyanilino)-6-phenyl-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2,4-dianilino-5,6-dihydro-6-phenyl-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-[(2-chloroethyl)amino]-5,6-dihydro-6-phenyl-2-piperidino-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-anilino-5,6-dihydro-6-(p-methoxyphenyl)-2-morpholino-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-anilino-5,6-dihydro-6-(p-methoxyphenyl)-2-piperidino-7H-pyrrolo[3,4-d]pyrimidin-7-one;
5,7-dihydro-2,4-dimorpholino-7-oxo-6H-Pyrrolo[3,4-d]pyrimidine-6-acetic acid 2-hydroxyethyl ester;
6-benzyl-5,6-dihydro-2,4-dimorpholino-7H-pyrrolo[3,4-d]pyrimidin-7-one;
5,6-dihydro-2,4-dimorpholino-6-phenyl-7H-pyrrolo[3,4-d]pyrimidin-7-one;
5,6-dihydro-6-(2-hydroxyethyl)-2,4-dipiperidino-7H-pyrrolo[3,4-d]pyrimidin-7-one; and
5,6-dihydro-6-phenyl-2,4-di-1-piperidinyl-7H-pyrrolo[3,4-d]pyrimidin-7-one.
2 . A compound as claimed in claim 1 , wherein
R 1 is hydrogen or C 1-4 alkyl; and
R 2 is C 2-10 heteroaryl-C 1-4 alkyl, C 3-6 heterocycloalkyl, or C 6-10 aryl-C 1-4 alkyl, wherein said C 2-10 heteroaryl-C 1-4 alkyl, C 3-6 heterocycloalkyl, and C 6-10 aryl-C 1-4 alkyl are optionally substituted with one or more groups selected from halogen, cyano, nitro, C 1-4 alkoxy, C 1-6 alkyl, halogenated C 1-6 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkoxy, —(CH 2 ) m —C(═O)NR 7 R 8 , —(CH 2 ) m —S(═O) 2 NR 7 R 8 , —(CH 2 ) m NH—C(═O)NR 7 R 8 , —(CH 2 ) m —N(R 7 )C(═O)R 3 , —(CH 2 ) m —N(R 7 )C(═O)—OR 8 , —(CH 2 ) m —C(═O)—OR 7 , —(CH 2 ) m —C(═O)R 7 , —(CH 2 ) m —S(═O) 2 R 7 , —(CH 2 ) m —S(═O)R 7 , —(CH 2 ) m —SR 7 , —(CH 2 ) m —C(═O)—R 7 , —(CH 2 ) m —OR 7 , —(CH 2 ) m —NR 7 R 8 , hydroxy, phenyl, benzyl, phenylethyl, halogenated phenyl, halogenated benzyl and halogenated phenylethyl, wherein said phenyl, benzyl, phenylethyl, halogenated phenyl, halogenated benzyl and halogenated phenylethyl are optionally substituted with one or more groups selected from —OH, methoxy, ethoxy, halogenated C 1-6 alkyl, and C 1-6 alkyl, wherein said R 7 and R 3 are independently selected from —H, C 1-6 alkyl, C 6-10 aryl, C 1-5 heterocyclyl, and C 3-6 cycloalkyl-C 0-4 alkyl, wherein said C 1-6 alkyl, C 6-10 aryl, C 1-5 heterocyclyl, and C 3-6 cycloalkyl-C 0-4 alkyl used in defining R 7 and R 8 are optionally substituted with one or more groups selected from —OH, methoxy, ethoxy and halogen.
3 . A compound as claimed in claim 1 , wherein
R 1 is hydrogen or C 1-4 alkyl; and R 2 is selected from cyclopentyl, 10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridine-5-yl, phenyl, tetrahydronaphthalenylmethyl, 1,7-diazabicyclo[4.3.0]nona-2,4,6,8-teraen-8-ylmethyl, 6,7-diazabicylco[3.3.0]octa-7,9-dien-8-ylmethyl, oxadiazolylmethyl, oxazolylmethyl, 2,3-dihydro-1H-indenyl, 1,2,3,4-tetrahydroquinolinylmethyl, quinolinylmethyl, isoquinolinylmethyl, pyrrolidinyl, pyrazolylmethyl, dihydrobenzofuranylmethyl, pyridinylmethyl, chromanylmethyl, isochromanylmethyl, indolylmethyl, benzothiozolylmethyl, benzyl and phenylethyl, wherein said cyclopentyl, 10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridine-5-yl, phenyl, tetrahydronaphthalenylmethyl, 1,7-diazabicyclo[4.3.0]nona-2,4,6,8-teraen-8-ylmethyl, 6,7-diazabicylco[3.3.0]octa-7,9-dien-8-ylmethyl, oxadiazolylmethyl, oxazolylmethyl, 2,3-dihydro-1H-indenyl, 1,2,3,4-tetrahydroquinolinylmethyl, quinolinylmethyl, isoquinolinylmethyl, pyrrolidinyl, pyrazolylmethyl, dihydrobenzofuranylmethyl, pyridinylmethyl, chromanylmethyl, isochromanylmethyl, indolylmethyl, benzothiozolylmethyl, benzyl and phenylethyl are optionally substituted with one or more groups selected from halogen, cyano, nitro, C 1-4 alkoxy, C 1-6 alkyl, halogenated C 1-6 alkyl, C 3-6 heterocycloalkyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl-C 1-4 alkoxy, C 3-6 cycloalkoxy, —(CH 2 ) m —C(═O)NR 7 R 8 , —(CH 2 ) m —S(═O) 2 NR 7 R 8 , —(CH 2 ) m NH—C(═O)NR 7 R 8 , —(CH 2 ) m —N(R 7 )C(═O)R 8 —(CH 2 ) m —N(R 7 )C(═O)—OR 8 —(CH 2 ) m —C(═O)—OR 7 —(CH 2 ) m —C(═O)R 7 , —(CH 2 ) m —S(═O) 2 R 7 , —(CH 2 ) m —S(═O)R 7 —(CH 2 ) m —SR 7 —(CH 2 ) m —O—C(═O)—R 7 —(CH 2 ) m —OR 7 —(CH 2 ) m —NR 7 R 8 hydroxy, phenyl, benzyl, phenylethyl, halogenated phenyl, halogenated benzyl and halogenated phenylethyl.
4 . A compound as claimed in claim 1 , wherein
R 1 is hydrogen or C 1-4 alkyl; and R 2 is selected from cyclopentyl, 10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridine-5-yl, phenyl, tetrahydronaphthalenylmethyl, 1,7-diazabicyclo[4.3.0]nona-2,4,6,8-teraen-8-ylmethyl, 6,7-diazabicylco[3.3.0]octa-7,9-dien-8-ylmethyl, oxadiazolylmethyl, oxazolylmethyl, 2,3-dihydro-1H-indenyl, 1,2,3,4-tetrahydroquinolinylmethyl, quinolinylmethyl, isoquinolinylmethyl, pyrrolidinyl, pyrazolylmethyl, dihydrobenzofuranylmethyl, pyridinylmethyl, chromanylmethyl, isochromanylmethyl, indolylmethyl, benzothiozolylmethyl, benzyl and phenylethyl wherein said cyclopentyl, 10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridine-5-yl, phenyl, tetrahydronaphthalenylmethyl, 1,7-diazabicyclo[4.3.0]nona-2,4,6,8-teraen-8-ylmethyl, 6,7-diazabicylco[3.3.0]octa-7,9-dien-8-ylmethyl, oxadiazolylmethyl, oxazolylmethyl, 2,3-dihydro-1H-indenyl, 1,2,3,4-tetrahydroquinolinylmethyl, quinolinylmethyl, isoquinolinylmethyl, pyrrolidinyl, pyrazolylmethyl, dihydrobenzofuranylmethyl, pyridinylmethyl, chromanylmethyl, isochromanylmethyl, indolylmethyl, benzothiozolylmethyl, benzyl and phenylethyl are optionally substituted with one or more groups selected from hydroxyl, methoxy, ethoxy, methoxymethyl, cyclopropylmethoxy, halogenated C 1-3 alkoxy, halogenated C 1-3 alkyl, halogen, methyl, ethyl, isopropyl, phenyl, benzyl, phenylethyl, halogenated phenyl, halogenated benzyl and halogenated phenylethyl.
5 . A compound as claimed in claim 1 , wherein R 1 and R 2 together with the nitrogen connected thereto form a C 3-6 heterocycloalkyl, wherein said C 3-6 heterocycloalkyl is optionally substituted with one or more groups selected from halogen, cyano, nitro, C 1-4 alkoxy, C 1-6 alkyl, halogenated C 1-6 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkoxy, —(CH 2 ) m —C(═O)NR 7 R 8 , —(CH 2 ) m —S(═O) 2 NR 7 R 8 , —(CH 2 ) m NH—C(═O)NR 7 R 8 , —(CH 2 ) m —N(R 7 )C(═O)R 8 , —(CH 2 ) m —N(R 7 )C(═O)—OR 8 —(CH 2 ) m —C(═O)—OR 7 —(CH 2 ) m —C(═O)R 7 —(CH 2 ) m —S(═O) 2 R 7 —(CH 2 ) m —S(═O)R 7 , —(CH 2 ) m —SR 7 —(CH 2 ) m —O—C(═O)—R 7 —(CH 2 ) m —R 7 , (CH 2 ) m —NR 7 R 8 hydroxy C 2-9 heterocyclyl, phenyl, benzyl, phenylethyl, halogenated phenyl, halogenated benzyl and halogenated phenylethyl, wherein said C 2-9 heterocyclyl, phenyl, benzyl, phenylethyl, halogenated phenyl, halogenated benzyl and halogenated phenylethyl are optionally substituted with one or more groups selected from hydroxyl, methoxy, ethoxy, methoxymethyl, cyclopropylmethoxy, halogen, methyl, ethyl, phenyl, benzyl, phenylethyl, halogenated phenyl, halogenated benzyl and halogenated phenylethyl.
6 . A compound as claimed in claim 1 , wherein R 1 and R 2 together with the nitrogen connected thereto form pyrrolidinyl, morpholinyl or azetidinyl, wherein said pyrrolidinyl, morpholinyl, and azetidinyl are optionally substituted with one or more groups selected from methoxy, ethoxy, halogen, methyl, ethyl, quinolinyl, isoquinolinyl, oxadiazolyl, phenyl, and benzyl; wherein said quinolinyl, isoquinolinyl, oxadiazolyl, phenyl, and benzyl groups may be optionally substituted from halogen, cyano, nitro, C 1-4 alkoxy, C 1-6 alkyl, halogenated C 1-6 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkoxy, —(CH 2 ) m —C(═O)NR 7 R 8 , —(CH 2 ) m —S(═O) 2 NR 7 R 8 , —(CH 2 ) m NH—C(═O)NR 7 R 8 , —(CH 2 ) m —N(R 7 )C(═O)R 8 —(CH 2 ) m —N(R 7 )C(═O)—OR 8 , —(CH 2 ) m —C(═O)—OR 7 , —(CH 2 ) m —C(═O)R 7 , —(CH 2 ) m —S(═O) 2 R 7 , —(CH 2 ) m —S(═O)R 7 —(CH 2 ) m —SR 7 , —(CH 2 ) m —O—C(═O)—R 7 , —(CH 2 ) m —OR 7 —(CH 2 ) m —NR 7 R 8 hydroxy, phenyl, benzyl, phenylethyl, halogenated phenyl, halogenated benzyl and halogenated phenylethyl.
7 . A compound as claimed in claim 1 , wherein R 3 is hydrogen and R 4 is quinuclidinyl or C 1-4 alkyl, wherein said quinuclidinyl and C 1-4 alkyl are optionally substituted with one or more groups selected from methylsulfonyl, dimethylamino, methylamino, acetylamino, hydroxy, methoxy, ethoxy, halogen, methyl, ethyl, 2-oxopyrrolidin-1-yl, tetrahydrofuranyl, phenyl, halogenated phenyl, pyridyl, halogenated pyridyl, halogenated benzyl and benzyl.
8 . A compound as claimed in claim 1 , wherein R 3 and R 4 together with the nitrogen connected thereto form a C 2-9 heterocyclyl, wherein said C 2-9 heterocyclyl is optionally substituted by one or more groups selected from C 1-6 alkyl, halogenated C 1-6 alkyl, halogen, methoxy, ethoxy, morpholinyl, hydroxy, —(CH 2 ) m —C(═O)NR 7 R 8 , —C(═O)—(CH 2 ) m —NR 7 R 8 , —(CH 2 ) m —S(═O) 2 NR 7 R 8 , —(CH 2 ) m —N(R 7 )C(═O)R 8 , —(CH 2 ) m —C(═O)R 7 , —(CH 2 ) m —S(═O) 2 R 7 , and —(CH 2 ) m —NR 7 R 8 ; wherein R 7 and R 3 are independently selected from —H, C 1-6 alkyl, and C 3-6 cycloalkyl-C 0-4 alkyl; and m is 0, 1, 2 or 3.
9 . A compound as claimed in claim 1 , wherein R 3 and R 4 together with the nitrogen connected thereto form a group selected from piperazinyl, piperidinyl, hexahydro-oxazolo[3,4-a]pyrazin-3-one-7-yl, hexahydro-pyrrolo[1,2-a]pyrazin-2-yl, 3-oxopiperazin-1-yl, 1,4-diazepan-1-yl, 2,5-diazabicyclo[2.2.1]hept-2-yl, 6-oxohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl, morpholinyl and pyrrolidinyl, wherein piperazinyl, piperidinyl, hexahydro-oxazolo[3,4-a]pyrazin-3-one-7-yl, hexahydro-pyrrolo[1,2-a]pyrazin-2-yl, 3-oxopiperazin-1-yl, 1,4-diazepan-1-yl, 2,5-diazabicyclo[2.2.1]hept-2-yl, 6-oxohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl, 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl, morpholinyl and pyrrolidinyl are optionally substituted by one or more groups selected from methyl, ethyl, isopropyl, cyclopropyl, acetyl, cyclopropylcarbonyl, isopropylcarbonyl, ethylcarbonyl, acetylamino, methylsulfonyl, and dimethylaminocarbonylmethyl.
10 . A compound as claimed in claim 1 , wherein R 5 is n-propyl or isopropyl.
11 . A compound as claimed in claim 1 wherein each R 7 and R 8 are independently selected from —H and C 1-6 alkyl.
12 . A compound as claimed in claim 1 wherein
each R 7 and R 8 are independently selected from —H, C 1-6 alkyl, C 6-10 aryl, C 1-5 heterocyclyl, and C 3-6 cycloalkyl-C 0-4 alkyl, wherein said C 1-6 alkyl, C 6-10 aryl, C 1-5 heterocyclyl, and C 3-6 cycloalkyl-C 0-4 alkyl are optionally substituted with one or more groups selected from —OH, methoxy, ethoxy and halogen.
13 . A compound as claimed in claim 1 wherein m is 0.
14 . A compound as claimed in claim 1 wherein m is 1.
15 . A compound as claimed in claim 1 wherein m is 2.
16 . A compound selected from:
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(1,2,3,4-tetrahydronaphthalen-1-ylamino)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
ethyl 3-{[2-(4-acetylpiperazin-1-yl)-6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl]amino}-2-phenylpropanoate;
2-(4-acetylpiperazin-1-yl)-4-[benzyl(tetrahydrofuran-2-ylmethyl)amino]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-[cyclopentyl(4-fluorobenzyl)amino]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-{[1-(4-tert-butylphenyl)ethyl]amino}-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-{[1-(4-isobutylphenyl)ethyl]amino}-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-{[2-(dimethylamino)ethyl]amino}-6-isopropyl-4-{[(4-methylphenyl)(phenyl)methyl]amino}-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-{[2-(4-chlorophenyl)propyl]amino}-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-{[(4-chlorophenyl)(phenyl)methyl]amino}-2-{[2-(dimethylamino)ethyl]amino}-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-{[1-(4-isopropylphenyl)-2-methylpropyl]amino}-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-{[(1R)-1-(4-methoxyphenyl)ethyl]amino}-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-{[2-(4-fluorophenyl)-1-methylethyl]amino}-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-{[1-(3-phenyl-1,2,4-oxadiazol-5-yl)ethyl]amino}-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-{[2-(4-fluorophenyl)-1,1-dimethylethyl]amino}-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-({[1-(4-chlorophenyl)cyclobutyl]methyl}amino)-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-{[2-(4-chlorophenyl)-2-methylpropyl]amino}-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-{[bis(4-fluorophenyl)methyl]amino}-2-{[2-(dimethylamino)ethyl]amino}-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-{[(4-chlorophenyl)(phenyl)methyl]amino}-2-(4-ethylpiperazin-1-yl)-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-{[(4-chlorophenyl)(phenyl)methyl]amino}-2-[[2-(dimethylamino)ethyl](methyl)amino]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-{[(4-chlorophenyl)(phenyl)methyl]amino}-6-isopropyl-2-(5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-{[2-(dimethylamino)ethyl]amino}-4-[(9-fluoro-10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-yl)amino]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-{[2-(dimethylamino)ethyl]amino}-4-[(7-fluoro-10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-yl)amino]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-{[bis(4-fluorophenyl)methyl]amino}-6-isopropyl-2-(5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-{[bis(4-fluorophenyl)methyl]amino}-2-[[2-(dimethylamino)ethyl](methyl)amino]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-({1-[4-(trifluoromethoxy)phenyl]ethyl}amino)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-{[1-(4-ethoxyphenyl)ethyl]amino}-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-{[(4-chlorophenyl)(cyclopropyl)methyl]amino}-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-({1-[4-(trifluoromethyl)phenyl]ethyl}amino)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-{[1-(4-propylphenyl)ethyl]amino}-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-{[4-(trifluoromethoxy)benzyl]amino}-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-({1-[4-(trifluoromethyl)phenyl]propyl}amino)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-{[trans-2-(4-chlorophenyl)cyclopentyl]amino}-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-{[(1R)-1-(4-methylphenyl)ethyl]amino}-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
{[2-(4-acetylpiperazin-1-yl)-6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl]amino}[4-(trifluoromethyl)phenyl]acetic acid;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-{[1-(4-methylphenyl)propyl]amino}-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-{[(1-methyl-1,2,3,4-tetrahydroquinolin-6-yl)methyl]amino}-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-[2-ethyl-2-(4-methylphenyl)hydrazino]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-{[1-(4-isopropylphenyl)ethyl]amino}-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-{[2-(4-chlorophenyl)ethyl]amino}-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-{[2-(4-methylphenyl)ethyl]amino}-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-[(4-isopropylbenzyl)amino]-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-[2-(4-chlorobenzyl)pyrrolidin-1-yl]-6-isopropyl-2-[(2-methoxyethyl)amino]-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
N-[2-({4-[2-(4-chlorobenzyl)pyrrolidin-1-yl]-6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl}amino)ethyl]acetamide;
2-(4-acetylpiperazin-1-yl)-4-[2-(2-chlorobenzyl)pyrrolidin-1-yl]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-[2-(4-methylbenzyl)pyrrolidin-1-yl]-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-[2-(3-chlorobenzyl)pyrrolidin-1-yl]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-[2-(4-chlorobenzyl)pyrrolidin-1-yl]-6-isopropyl-2-(3-oxopiperazin-1-yl)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-[2-(4-chlorobenzyl)pyrrolidin-1-yl]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-[benzyl(cyclopropylmethyl)amino]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-[2-(4-chlorophenyl)pyrrolidin-1-yl]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-{[1-(4-chlorophenyl)ethyl]amino}-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-(2-benzylpyrrolidin-1-yl)-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-{[2-(3,4-dimethylphenyl)ethyl]amino}-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-{[2-(2,4-dimethylphenyl)ethyl]amino}-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-[2-(4-chlorobenzyl)pyrrolidin-1-yl]-2-{[2-(dimethylamino)ethyl]amino}-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-[benzyl(4-chlorobenzyl)amino]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-[(4-chlorobenzyl)(cyclopropylmethyl)amino]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-{[2-(4-chlorophenyl)-1,1-dimethylethyl]amino}-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-{[2-(4-chlorophenyl)-1,1-dimethylethyl]amino}-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
N-[1-(4-{[2-(4-chlorophenyl)-1,1-dimethylethyl]amino}-6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)pyrrolidin-3-yl]acetamide;
2-[4-(4-{[2-(4-chlorophenyl)-1,1-dimethylethyl]amino}-6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)piperazin-1-yl]-N,N-dimethylacetamide;
4-{[2-(4-chlorophenyl)-1,1-dimethylethyl]amino}-2-(4-ethylpiperazin-1-yl)-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetyl-1,4-diazepan-1-yl)-4-{[2-(4-chlorophenyl)-1,1-dimethylethyl]amino}-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-{[2-(4-chlorophenyl)-1,1-dimethylethyl]amino}-6-isopropyl-2-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
N-[1-(4-{[2-(4-chlorophenyl)-1,1-dimethylethyl]amino}-6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)pyrrolidin-3-yl]-N-methylacetamide;
4-{[2-(4-chlorophenyl)-1,1-dimethylethyl]amino}-6-isopropyl-2-(5-oxo-1,4-diazepan-1-yl)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-{[2-(4-chlorophenyl)-1,1-dimethylethyl]amino}-6-isopropyl-2-(4-methyl-3-oxopiperazin-1-yl)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-{[2-(4-chlorophenyl)-1,1-dimethylethyl]amino}-6-isopropyl-2-{[2-(2-oxopyrrolidin-1-yl)ethyl]amino}-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-{[2-(4-chlorophenyl)-1,1-dimethylethyl]amino}-6-isopropyl-2-(4-propionylpiperazin-1-yl)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-Acetyl-piperazin-1-yl)-4-(benzhydryl-amino)-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
4-(Benzhydryl-amino)-6-isobutyl-2-morpholin-4-yl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
4-(Benzhydryl-amino)-6-cyclopropyl-2-morpholin-4-yl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
4-(Benzhydryl-amino)-6-cyclopentyl-2-morpholin-4-yl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
6-isopropyl-2-morpholin-4-yl-[(phenyl-p-tolyl-methyl)-amino]-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
4-{[(4-Chloro-phenyl)-phenyl-methyl]-amino}-6-isopropyl-2-morpholin-4-yl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
4-(Benzhydryl-amino)-2-(4-ethyl-piperazin-1-yl)-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
4-(Benzhydryl-amino)-2-(4-cyclopropanecarbonyl-piperazin-1-yl)-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
4-(Benzhydryl-amino)-2-(4-isobutyryl-piperazin-1-yl)-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
4-(Benzhydryl-amino)-6-isopropyl-2-morpholin-4-yl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
4-(Benzhydryl-amino)-6-dimethylamino-2-(4-methyl-piperazin-1-yl)-5,6-dihydro-cyclopentapyrimidin-7-one;
4-(Benzhydryl-amino)-6-isopropyl-2-piperazin-1-yl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
4-(Benzhydryl-amino)-2-benzylamino-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
4-(Benzhydryl-amino)-6-isopropyl-2-(2-methoxy-ethylamino)-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
4-(Benzhydryl-amino)-2-(2,6-dimethyl-morpholin-4-yl)-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
4-(Benzhydryl-amino)-6-isopropyl-2-(4-propionyl-piperazin-1-yl)-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-Acetyl-piperazin-1-yl)-4-(1,2-diphenyl-ethylamino)-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
4-(Benzhydryl-amino)-2-diethylamino-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
2-{4-[4-(Benzhydryl-amino)-6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl]-piperazin-1-yl}-N,N-dimethyl-acetamide;
2-(4-acetylpiperazin-1-yl)-4-[(2,2-diphenylethyl)amino]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-(Benzhydryl-amino)-6-isopropyl-2-(4-methanesulfonyl-piperazin-1-yl)-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
N-{2-[4-(Benzhydryl-amino)-6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamino]-ethyl}-acetamide;
4-(Benzhydryl-amino)-6-isopropyl-2-[(pyridin-3-ylmethyl)-amino]-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-Acetyl-piperazin-1-yl)-4-dibenzylamino-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]-pyrimidin-7-one;
N-{1-[4-(Benzhydryl-amino)-6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl]-pyrrolidin-3-yl}-acetamide;
4-(Benzhydryl-amino)-2-(2-dimethylamino-ethylamino)-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
6-isopropyl-2-(2-methoxy-ethylamino)-4-[(phenyl-p-tolyl-methyl)-amino]-5,6-dihydro-pyrrolo[3,4-d]-pyrimidin-7-one;
4-(Benzhydryl-amino)-2-[4-(2-dimethylamino-acetyl)-piperazin-1-yl]-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
4-(Benzhydryl-amino)-6-dimethylamino-2-(2-hydroxy-ethylamino)-5,6-dihydro-cyclopentapyrimidin-7-one;
2-(4-Ethyl-piperazin-1-yl)-6-isopropyl-4-[(phenyl-p-tolyl-methyl)-amino]-5,6-dihydro-pyrrolo[3,4-d]-pyrimidin-7-one;
2-(4-isopropyl-piperazin-1-yl)-6-isopropyl-4-[(phenyl-p-tolyl-methyl)-amino]-5,6-dihydro-pyrrolo[3,4-d]-pyrimidin-7-one;
2-(4-Acetyl-piperazin-1-yl)-6-isopropyl-4-{[(4-methoxy-phenyl)-phenyl-methyl]-amino}-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-Acetyl-piperazin-1-yl)-4-(4-chloro-benzylamino)-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]-pyrimidin-7-one;
2-(4-Acetyl-piperazin-1-yl)-6-isopropyl-4-(3-isopropyl-phenyl amino)-5,6-dihydro-pyrrolo[3,4-d]-pyrimidin-7-one;
4-Dibenzylamino-2-(2-dimethylamino-ethylamino)-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]-pyrimidin-7-one;
4-(2,2-Diphenyl-ethylamino)-2-(4-ethyl-piperazin-1-yl)-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
2-(3-Dimethylamino-propylamino)-4-(2,2-diphenyl-ethylamino)-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
4-(2,2-Diphenyl-ethylamino)-6-isopropyl-2-(2-methylamino-ethylamino)-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
4-[(diphenylmethyl)amino]-2-morpholin-4-yl-6-propyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-[(4-chlorobenzyl)(methyl)amino]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-({(1R)-1-[4-(trifluoromethoxy)phenyl]ethyl}amino)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-({[1-(4-chlorophenyl)cyclopentyl]methyl}amino)-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-({(1R)-1-[4-(difluoromethoxy)phenyl]ethyl}amino)-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-{[(1R)-1-(4-ethoxyphenyl)ethyl]amino}-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-[(2R)-2-benzylpyrrolidin-1-yl]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-[(2S)-2-benzylpyrrolidin-1-yl]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-ethyl-4-{[2-(4-fluorophenyl)-1,1-dimethylethyl]amino}-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-ethylpiperazin-1-yl)-6-isopropyl-4-{[phenyl(pyridin-2-yl)methyl]amino}-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-ethylpiperazin-1-yl)-4-[(9-fluoro-10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-yl)amino]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-[[2-(dimethylamino)ethyl](methyl)amino]-4-[(9-fluoro-10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-yl)amino]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-{[2-methyl-4-(trifluoromethoxy)benzyl]amino}-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-[2-(4-chlorophenyl)-2-methylmorpholin-4-yl]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-{[2-(4-chlorophenyl)-1,1-dimethylethyl]amino}-2-(4-isobutyrylpiperazin-1-yl)-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-{[2-(4-chlorophenyl)-1,1-dimethylethyl]amino}-2-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-{[2-(4-chlorophenyl)-1,1-dimethylethyl]amino}-2-[4-(cyclopropylcarbonyl)piperazin-1-yl]-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-(4-{[2-(4-chlorophenyl)-1,1-dimethylethyl]amino}-6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)-N,N-dimethylpiperazine-1-carboxamide;
4-(4-{[2-(4-chlorophenyl)-1,1-dimethylethyl]amino}-6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)piperazine-1-carbaldehyde;
2-(4-Acetylpiperazin-1-yl)-4-[2-(4-fluorobenzyl)-pyrrolidin-1-yl]-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-Acetylpiperazin-1-yl)-4-[1-(4-fluorophenyl)-cyclopropylamino]-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-Acetylpiperazin-1-yl)-6-isopropyl-4-(2-(3-methoxyphenyl)pyrrolidin-1-yl)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-Acetylpiperazin-1-yl)-4-(2-(3-chlorophenyl)pyrrolidin-1-yl)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
4-[(4-benzylphenyl)amino]-6-isopropyl-2-morpholin-4-yl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-Acetylpiperazin-1-yl)-4-(5-chloro-2,3-dihydro-1H-inden-1-ylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
4-(1-(4-Fluorophenyl)-2-methylpropan-2-ylamino)-6-isopropyl-2-(6-oxohexahydro[1,2-a]pyrazin-2(1H)-yl)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
6-Isopropyl-2-(6-oxohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-4-(quinolin-3-ylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
6-Isopropyl-2-(6-oxohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-4-(quinolin-3-ylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(5,6-Dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-6-isopropyl-4-(quinolin-3-ylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-Acetyl-3-methyl-piperazin-1-yl)-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylamino]-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-Acetyl-2-methyl-piperazin-1-yl)-4-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethylamino]-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
(R)-7-{4-[2-(4-Fluoro-phenyl)-1,1-dimethyl-ethylamino]-6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl}-hexahydro-oxazolo[3,4-a]pyrazin-3-one;
(R)-2-(Hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-6-isopropyl-4-[(quinolin-3-ylmethyl)-amino]-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-Acetyl-3-methyl-piperazin-1-yl)-6-isopropyl-4-[(quinolin-3-ylmethyl)-amino]-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one;
4-(4-acetylpiperazin-1-yl)-8-propan-2-yl-2-[(5-tert-butyl-1H-pyrazol-3-yl)methylamino]-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-[(5-phenyl-1,2-oxazol-3-yl)methylamino]-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-[(3-phenyl-1,2,4-oxadiazol-5-yl)methylamino]-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-[(1-phenylpyrazol-4-yl)methylamino]-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-[(3-phenyl-1,2-oxazol-5-yl)methylamino]-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methylamino]-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-[1-[1-(2-fluorophenyl)pyrazol-4-yl]ethylamino]-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-[1-(1-phenylpyrazol-4-yl)ethylamino]-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-(6,7-diazabicyclo[3.3.0]octa-7,9-dien-8-ylmethylamino)-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-[(1-cyclopentyl-3-methyl-pyrazol-4-yl)methylamino]-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-2,4,10-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-[(1-methyl-5-phenyl-pyrazol-3-yl)methylamino]-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-[(2-methyl-5-phenyl-pyrazol-3-yl)methylamino]-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-(1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-8-ylmethylamino)-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(3-ethoxyphenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-((1-(4-ethoxyphenyl)ethyl)(methyl)amino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-ethoxy-3-fluorophenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(3-chloro-4-ethoxyphenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(2,3-dihydrobenzofuran-5-yl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-(1-(2-(4-acetylpiperazin-1-yl)-6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-ylamino)ethyl)phenyl)-2-methylpropanenitrile;
2-(4-acetylpiperazin-1-yl)-4-((cyclopropylmethyl)(4-ethoxybenzyl)amino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-(1-(2-(4-acetylpiperazin-1-yl)-6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-ylamino)ethyl)-2-fluorophenyl)-2-methylpropanenitrile;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(2-methyl-1-p-tolylpropan-2-ylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-iodophenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-ethoxy-3-methylphenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-ethoxy-2-methylphenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(2,2-dimethylchroman-6-yl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(3,4-dimethylphenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-chloro-3-(trifluoromethyl)phenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(2,3-dihydro-1H-inden-5-yl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(2-ethoxyphenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(3-ethoxy-4-methylphenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-ethoxyphenyl)propylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-isopropoxyphenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(S)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-ethoxyphenyl)-2,2,2-trifluoroethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-(1-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one (Isomer 1);
2-(4-acetylpiperazin-1-yl)-4-(1-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one (Isomer 2);
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-ethoxyphenyl)-2-hydroxyethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(3-(difluoromethoxy)phenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(3-fluoro-4-(trifluoromethyl)phenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(2-fluoro-5-(trifluoromethyl)phenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(3-fluoro-5-(trifluoromethyl)phenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(cyclopropyl(4-ethoxyphenyl)methylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(2-fluoro-4-(trifluoromethyl)phenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(2-fluoro-3-(trifluoromethyl)phenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-fluoro-3-(trifluoromethyl)phenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(S)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-ethoxyphenyl)-2-hydroxyethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(3-fluoro-4-isopropoxyphenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-cyclobutoxyphenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-cyclopropylphenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(3-fluoro-4-propoxyphenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(5-chloro-6-ethoxypyridin-3-yl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(1-(2-methoxyphenyl)-2-methylpropan-2-ylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(1-(4-methoxyphenyl)-2-methylpropan-2-ylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(2-methyl-1-o-tolylpropan-2-ylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-(1-(4-ethoxyphenyl)-2-methylpropan-2-ylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-(benzo[d]thiazol-2-ylmethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
6-isopropyl-4-((isoquinolin-3-ylmethyl)(methyl)amino)-2-(4-methyl-3-oxopiperazin-1-yl)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-4-(1-(4-ethoxy-3-fluorophenyl)ethylamino)-6-isopropyl-2-(4-methyl-3-oxopiperazin-1-yl)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-ethoxy-2-methoxyphenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-isopropoxy-2-methoxyphenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-ethoxy-2-fluorophenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-(isochroman-1-ylmethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
6-isopropyl-2-(3-oxopiperazin-1-yl)-4-(quinolin-3-ylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
N-(1-(6-isopropyl-7-oxo-4-(quinolin-3-ylmethylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)pyrrolidin-3-yl)acetamide;
N-(1-(6-isopropyl-7-oxo-4-(quinolin-3-ylmethylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)pyrrolidin-3-yl)-N-methylacetamide;
1-(6-isopropyl-7-oxo-4-(quinolin-3-ylmethylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)piperidine-4-carboxamide;
6-isopropyl-2-(4-methyl-3-oxopiperazin-1-yl)-4-(quinolin-3-ylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
6-isopropyl-2-morpholino-4-(quinolin-3-ylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
6-isopropyl-2-[2-(morpholinomethyl)pyrrolidin-1-yl]-4-(3-quinolylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(3-dimethylaminopyrrolidin-1-yl)-6-isopropyl-4-(3-quinolylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7-one;
6-isopropyl-4-(3-quinolylmethylamino)-2-(quinuclidin-3-ylamino)-5H-pyrrolo[3,4-d]pyrimidin-7-one;
6-isopropyl-2-(2-methylsulfonylethylamino)-4-(3-quinolylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(3,3-difluoropyrrolidin-1-yl)-6-isopropyl-4-(3-quinolylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7-one;
6-isopropyl-2-(methyl-(tetrahydrofuran-2-ylmethyl)amino)-4-(3-quinolylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-dimethylamino-1-piperidyl)-6-isopropyl-4-(3-quinolylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7-one;
6-(1-methylethyl)-4-[(quinolin-3-ylmethyl)amino]-2-[(tetrahydro-2H-pyran-4-ylmethyl)amino]-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(dimethylamino)-6-(1-methylethyl)-4-[(quinolin-3-ylmethyl)amino]-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
N,N-dimethyl-4-{6-(1-methylethyl)-7-oxo-4-[(quinolin-3-ylmethyl)amino]-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl}piperazine-1-carboxamide;
2-[4-(cyclopropylcarbonyl)piperazin-1-yl]-6-(1-methylethyl)-4-[(quinolin-3-ylmethyl)amino]-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-(2-(4-ethylpiperazin-1-yl)-4-(trifluoromethyl)benzylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(1-m-tolylpyrrolidin-3-ylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(2-methoxy-4-(trifluoromethyl)benzylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(1-(2-(trifluoromethyl)phenyl)ethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(1-(3-methoxyphenyl)ethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-((6-phenylpyridin-3-yl)methylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(isoquinolin-4-ylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(1-(3-(trifluoromethyl)phenyl)ethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(4-(trifluoromethyl)benzylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(2-methoxy-4-(trifluoromethoxy)benzylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(1-(quinolin-3-yl)ethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(S)-2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(1-(quinolin-3-yl)ethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(quinolin-6-ylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-(1-(benzo[d]thiazol-2-yl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-((1-methyl-1H-indol-2-yl)methylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(isoquinolin-3-ylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(methyl(quinolin-6-ylmethyl)amino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-((8-methoxyquinolin-5-yl)methylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-((2-methylquinolin-3-yl)methylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-((2-methylquinolin-6-yl)methylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(1-(quinolin-6-yl)ethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(S)-2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(1-(quinolin-6-yl)ethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-(ethyl(isoquinolin-3-ylmethyl)amino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-(ethyl(quinolin-3-ylmethyl)amino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-((8-methylquinolin-6-yl)methylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(quinolin-2-ylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(methyl(quinolin-2-ylmethyl)amino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-(1,3-difluoropropan-2-yloxy)phenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(S)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-(1,3-difluoropropan-2-yloxy)phenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-((1-(dimethylamino)isoquinolin-3-yl)methylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-((cyclopropylmethyl)(isoquinolin-3-ylmethyl)amino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(isopropyl(isoquinolin-3-ylmethyl)amino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-((isoquinolin-3-ylmethyl)(methyl)amino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-((2,2-difluoroethyl)(isoquinolin-3-ylmethyl)amino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-(ethyl(1-(quinolin-6-yl)ethyl)amino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one (Enantiomer 1);
2-(4-acetylpiperazin-1-yl)-4-(ethyl(1-(quinolin-6-yl)ethyl)amino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one (Enantiomer 2);
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-((1-methylisoquinolin-3-yl)methylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(methyl(1-(quinolin-6-yl)ethyl)amino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one (Enantiomer 1);
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(methyl(1-(quinolin-6-yl)ethyl)amino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one (Enantiomer 2);
(R)-2-(4-acetylpiperazin-1-yl)-4-((1-(4-ethoxy-3-fluorophenyl)ethyl)(methyl)amino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(methyl((1-methylisoquinolin-3-yl)methyl)amino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-((isoquinolin-3-ylmethyl)(2,2,2-trifluoroethyl)amino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
benzyl (2R)-1-[4-(4-acetylpiperazin-1-yl)-7-oxo-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-2-yl]pyrrolidine-2-carboxylate;
4-(4-acetylpiperazin-1-yl)-2-(2-benzyl-1-piperidyl)-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-[2-(4-dimethylaminophenyl)pyrrolidin-1-yl]-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-[2-[(4-fluorophenyl)methyl]-1-piperidyl]-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-[2-(3-methylphenyl)pyrrolidin-1-yl]-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-2,4,10-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-[2-(3,5-dimethylphenyl)pyrrolidin-1-yl]-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-2,4,10-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-(2-phenethylpyrrolidin-1-yl)-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-[2-(4-ethoxyphenyl)pyrrolidin-1-yl]-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-2,4,10-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-(2-benzylazetidin-1-yl)-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
4-(4-acetylpiperazin-1-yl)-8-propan-2-yl-2-(2-quinolin-3-ylpyrrolidin-1-yl)-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-[2-(1-phenylpropyl)pyrrolidin-1-yl]-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-2,4,10-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-[(3-cyclopentyl-1,2,4-oxadiazol-5-yl)methylamino]-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
tert-butyl (2R)-1-[4-(4-acetylpiperazin-1-yl)-7-oxo-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-2-yl]pyrrolidine-2-carboxylate;
4-(4-acetylpiperazin-1-yl)-2-[(5-cyclobutyl-1,2,4-oxadiazol-3-yl)methylamino]-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-[(2R)-2-(2,3-dihydroindole-1-carbonyl)pyrrolidin-1-yl]-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
4-(4-acetylpiperazin-1-yl)-2-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl]-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
4-(4-acetylpiperazin-1-yl)-8-propan-2-yl-2-(2-quinolin-6-ylpyrrolidin-1-yl)-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one;
4-(4-acetylpiperazin-1-yl)-8-propan-2-yl-2-(2-quinolin-3-ylpyrrolidin-1-yl)-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one (Enantiomer 1);
4-(4-acetylpiperazin-1-yl)-8-propan-2-yl-2-(2-quinolin-3-ylpyrrolidin-1-yl)-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one (Enantiomer 2);
4-(4-acetylpiperazin-1-yl)-8-propan-2-yl-2-(2-quinolin-6-ylpyrrolidin-1-yl)-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one (Enantiomer 1);
4-(4-acetylpiperazin-1-yl)-8-propan-2-yl-2-(2-quinolin-6-ylpyrrolidin-1-yl)-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one (Enantiomer 2);
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-[2-[(4-methoxyphenyl)methyl]pyrrolidin-1-yl]-5H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-[2-[(4-methoxyphenyl)methyl]pyrrolidin-1-yl]-5H-pyrrolo[3,4-d]pyrimidin-7-one (Enantiomer 1);
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-[2-[(4-methoxyphenyl)methyl]pyrrolidin-1-yl]-5H-pyrrolo[3,4-d]pyrimidin-7-one (Enantiomer 2);
2-(4-acetylpiperazin-1-yl)-4-[2-[(4-ethoxyphenyl)methyl]pyrrolidin-1-yl]-6-isopropyl-5H-pyrrolo[4,3-e]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-[2-[(2-methoxyphenyl)methyl]pyrrolidin-1-yl]-5H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-[2-[(3-methoxyphenyl)methyl]pyrrolidin-1-yl]-5H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-[2-(4-fluorophenyl)pyrrolidin-1-yl]-6-(1-methylethyl)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-{2-[4-(methoxymethyl)benzyl]pyrrolidin-1-yl}-6-(1-methylethyl)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
4-[2-(4-acetylbenzyl)pyrrolidin-1-yl]-2-(4-acetylpiperazin-1-yl)-6-(1-methylethyl)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-[2-(4-methoxy-3-methylphenyl)pyrrolidin-1-yl]-6-(1-methylethyl)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-(1-methylethyl)-4-[2-(4-methylphenyl)pyrrolidin-1-yl]-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-[2-(3,4-dichlorophenyl)pyrrolidin-1-yl]-6-(1-methylethyl)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-[2-(3,4-dimethylphenyl)pyrrolidin-1-yl]-6-(1-methylethyl)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-[2-(4-methoxyphenyl)pyrrolidin-1-yl]-6-(1-methylethyl)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-[(2R)-2-(4-ethoxy-3-fluorophenyl)pyrrolidin-1-yl]-6-(1-methylethyl)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
(4-chlorophenyl)methyl (2R)-1-[4-(4-acetylpiperazin-1-yl)-7-oxo-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-2-yl]pyrrolidine-2-carboxylate;
(2R)-1-[4-(4-acetylpiperazin-1-yl)-7-oxo-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-2-yl]-N-cyclohexyl-pyrrolidine-2-carboxamide;
4-(4-acetylpiperazin-1-yl)-2-[(2R)-2-(4-methylpiperidine-1-carbonyl)pyrrolidin-1-yl]-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-2,4,10-trien-7-one;
phenyl (2R)-1-[4-(4-acetylpiperazin-1-yl)-7-oxo-8-propan-2-yl-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-2-yl]pyrrolidine-2-carboxylate;
3-(4-acetylpiperazin-1-yl)-5-[[1-(4-fluorophenyl)-2-methyl-propan-2-yl]amino]-8-(oxan-4-yl)-2,4,8-triazabicyclo[4.3.0]nona-1,3,5-trien-9-one;
(+)-4-(4-acetylpiperazin-1-yl)-8-butan-2-yl-2-[(1-phenylpyrazol-4-yl)methylamino]-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one (Enantiomer 1);
(−)-4-(4-acetylpiperazin-1-yl)-8-butan-2-yl-2-[(1-phenylpyrazol-4-yl)methylamino]-3,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-7-one (Enantiomer 2);
(+)-2-(4-acetylpiperazin-1-yl)-4-(3-quinolylmethylamino)-6-sec-butyl-5H-pyrrolo[3,4-d]pyrimidin-7-one (Enantiomer 1);
(−)-2-(4-acetylpiperazin-1-yl)-4-(3-quinolylmethylamino)-6-sec-butyl-5H-pyrrolo[3,4-d]pyrimidin-7-one (Enantiomer 2);
(+)-2-(4-acetylpiperazin-1-yl)-4-(3-isoquinolylmethylamino)-6-sec-butyl-5H-pyrrolo[3,4-d]pyrimidin-7-one (Enantiomer 1);
(−)-2-(4-acetylpiperazin-1-yl)-4-(3-isoquinolylmethylamino)-6-sec-butyl-5H-pyrrolo[3,4-d]pyrimidin-7-one (Enantiomer 2);
2-(4-acetylpiperazin-1-yl)-6-sec-butyl-4-(1-(4-fluorophenyl)-2-methylpropan-2-ylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-(1-(4-fluorophenyl)-2-methylpropan-2-ylamino)-6-(3-methylbutan-2-yl)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-(1-(4-fluorophenyl)-2-methylpropan-2-ylamino)-6-(1-methoxypropan-2-yl)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-(2-chlorobenzyl)-4-(1-(4-fluorophenyl)-2-methylpropan-2-ylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-[(1S)-1-methylpropyl]-4-[(quinolin-3-ylmethyl)amino]-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-[ethyl(isoquinolin-3-ylmethyl)amino]-6-(1-methylpropyl)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one (Enantiomer 1);
2-(4-acetylpiperazin-1-yl)-4-[ethyl(isoquinolin-3-ylmethyl)amino]-6-(1-methylpropyl)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one (Enantiomer 2);
2-(4-acetylpiperazin-1-yl)-6-[(1S)-1-methylpropyl]-4-[methyl(quinolin-3-ylmethyl)amino]-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-{[(1R)-1-(4-ethoxy-3-fluorophenyl)ethyl]amino}-6-[(1S)-1-methylpropyl]-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-ethoxyphenyl)-2,2,2-trifluoroethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-(cyclopropylmethoxy)-3-fluorophenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-((2-methyl-2,3-dihydrobenzofuran-5-yl)methylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(1-(2-methyl-2,3-dihydrobenzofuran-5-yl)ethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(S)—N-(2-(4-acetyl-3-methylpiperazin-1-yl)-6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)-N-(isoquinolin-3-ylmethyl)acetamide;
(R)—N-(2-(4-acetyl-3-methylpiperazin-1-yl)-6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)-N-(isoquinolin-3-ylmethyl)acetamide;
(S)-2-(4-acetyl-3-methylpiperazin-1-yl)-6-isopropyl-4-(quinolin-3-ylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetyl-3-methylpiperazin-1-yl)-6-isopropyl-4-(quinolin-3-ylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
6-(1-methylethyl)-2-[4-(methylsulfonyl)piperazin-1-yl]-4-[(quinolin-3-ylmethyl)amino]-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(6-ethoxy-5-fluoropyridin-3-yl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(6-ethoxy-5-methylpyridin-3-yl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-(hydroxymethyl)phenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(2-methyl-1-m-tolylpropan-2-ylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-((4-ethoxy-2-methoxybenzyl)(methyl)amino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-(4-ethoxy-2-methoxybenzylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-((2-ethoxy-4-methoxybenzyl)(methyl)amino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-(4-isopropoxy-2-methoxybenzylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-({(1R)-1-[3-fluoro-4-(methoxymethyl)phenyl]ethyl}amino)-6-(1-methylethyl)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-[{[1-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl}(methyl)amino]-6-(1-methylethyl)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-4-{[2-(4-fluorophenyl)-1,1-dimethylethyl]amino}-6-(1-methylethyl)-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-4-(((7-chloroisoquinolin-3-yl)methyl)(methyl)amino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(methyl((6-methylisoquinolin-3-yl)methyl)amino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(quinolin-3-ylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(1-(quinolin-3-yl)ethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one (Enantiomer 1);
(S)-2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(1-(quinolin-3-yl)ethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one (Enantiomer 2);
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(methyl(quinolin-3-ylmethyl)amino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(methyl((2-methylquinolin-3-yl)methyl)amino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-(((6-chloroisoquinolin-3-yl)methyl)(methyl)amino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-(((6-fluoroisoquinolin-3-yl)methyl)(methyl)amino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-(((7-fluoroisoquinolin-3-yl)methyl)(methyl)amino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-4-(1-(2-(4-acetylpiperazin-1-yl)-6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-ylamino)ethyl)benzonitrile;
2-(4-Acetyl-2-methylpiperazin-1-yl)-6-isopropyl-4-(quinolin-3-ylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(methyl((7-methylisoquinolin-3-yl)methyl)amino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-6-(1-methylethyl)-4-{[(1-methyl-1H-indol-5-yl)methyl]amino}-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-(1-methylethyl)-4-{methyl[(1-methyl-1H-indol-6-yl)methyl]amino}-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
2-(4-acetylpiperazin-1-yl)-6-(1-methylethyl)-4-{[(1-methyl-1H-indol-6-yl)methyl]amino}-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(2,4-diethoxyphenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(4-((dimethylamino)methyl)phenyl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-2-(4-acetylpiperazin-1-yl)-4-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)ethylamino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-acetylpiperazin-1-yl)-4-(((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)(methyl)amino)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-4-(1-(4-ethoxyphenyl)ethylamino)-2-(4-ethyl-3-oxopiperazin-1-yl)-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
2-(4-ethyl-3-oxopiperazin-1-yl)-6-isopropyl-4-((isoquinolin-3-ylmethyl)(methyl)amino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
(R)-4-(1-(4-ethoxyphenyl)ethylamino)-6-isopropyl-2-(3-oxo-4-(2,2,2-trifluoroethyl)piperazin-1-yl)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one;
6-isopropyl-4-((isoquinolin-3-ylmethyl)(methyl)amino)-2-(3-oxo-4-(2,2,2-trifluoroethyl)piperazin-1-yl)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one; and pharmaceutically acceptable salts thereof.
17 - 20 . (canceled)
21 . A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier.
22 . A method for the therapy of pain in a warm-blooded animal, comprising the step of administering to said animal in need of such therapy a therapeutically effective amount of a compound according to claim 1 .
23 . A method for the therapy of over active bladder in a warm-blooded animal, comprising the step of administering to said animal in need of such therapy a therapeutically effective amount of a compound according to claim 1 .
24 . A method for preparing a compound of formula 1,
comprising reacting a compound of formula II with HNR 3 R 4
wherein:
X 1 is halogen;
R 1 and R 2 are independently selected from hydrogen, C 1-6 alkyl-C(═O)—, C 1-6 alkyl, C 2-6 alkenyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl-C 1-6 alkyl, C 3-7 cycloalkyl fused with a phenyl, —NR 7 R 8 , C 3-7 cycloalkyl fused with a phenyl and C 2-6 heteroaryl, C 1-14 heterocyclyl, C 1-14 heterocyclyl-C 1-6 alkyl, C 6-10 aryl, C 6-10 aryl-C 1-6 alkyl, or R 1 and R 2 together with the nitrogen connected thereto form a C 2-9 heterocyclyl; wherein said C 1-6 alkyl-C(═O)—, C 1-6 alkyl, C 2-6 alkenyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl-C 1-6 alkyl, C 3-7 cycloalkyl fused with a phenyl, C 1-14 heterocyclyl, C 1-14 heterocyclyl-C 1-6 alkyl, C 6-10 aryl, C 6-10 aryl-C 1-6 alkyl and C 2-9 heterocyclyl are optionally substituted by one or more groups selected from, halogen, cyano, nitro, C 1-6 alkoxy, C 1-4 haloalkoxy, C 1-6 alkyl, halogenated C 1-6 alkyl, C 3-6 -cycloalkyl, C 3-6 cycloalkoxy, C 3-6 cycloalkyl-C 1-4 alkoxy, —(CH 2 ) m —C(═O)NR 7 R 8 , —(CH 2 ) m —S(═O) 2 NR 7 R 8 , —(CH 2 ) m NH—C(═O)NR 7 R 8 , —(CH 2 ) m —N(R 7 )C(═O)R 8 , —(CH 2 ) m —N(R 7 )C(═O)—OR 8 , —(CH 2 ) m —C(═O)—OR 7 , —(CH 2 ) m —C(═O)R 7 , —(CH 2 ) m —S(═O) 2 R 7 , —(CH 2 ) m —S(═O)R 7 , —(CH 2 ) m —SR 7 , —(CH 2 ) m —O—C(═O)—R 7 , —(CH 2 ) m —OR 7 , —(CH 2 ) m —NR 7 R 8 hydroxy, C 1-14 heterocyclyl-C 0-4 -alkyl, phenyl, benzyl, phenylethyl, wherein said C 1-14 heterocyclyl-C 0-4 -alkyl, phenyl, benzyl or phenethyl optionally substituted by one or more groups selected from halogen, cyano, nitro, oxo, C 1-6 alkoxy, C 1-4 haloalkoxy, C 1-6 alkyl, halogenated C 1-6 alkyl, C 3-6 -cycloalkyl, C 3-6 cycloalkoxy, —(CH 2 ) m —C(═O)NR 7 R 8 , —C(═O)—(CH 2 ) m —NR 7 R 8 , —(CH 2 ) m —S(═O) 2 NR 7 R 8 , —(CH 2 ) m NH—C(═O)NR 7 R 8 , —(CH 2 ) m —N(R 7 )C(═O)R 8 , —(CH 2 ) m —N(R 7 )C(═O)—OR 8 , —(CH 2 ) m —C(═O)—OR 7 , —(CH 2 ) m —C(═O)R 7 , —(CH 2 ) m —S(═O) 2 R 7 , —(CH 2 ) m —S(═O)R 7 , —(CH 2 ) m —SR 7 , —(CH 2 ) m —O—C(═O)—R 7 , —(CH 2 ) m —OR 7 , —(CH 2 ) m —NR 7 R 8 and hydroxy;
R 3 and R 4 are independently selected from hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl-C 1-6 alkyl, C 6-10 aryl, C 6-10 aryl-C 1-6 alkyl, C 3-6 heterocyclyl, and C 3-6 heterocyclyl-C 1-6 alkyl; or R 3 and R 4 together with the nitrogen connected thereto form a C 2-9 heterocyclyl; wherein said C 1-6 alkyl, C 2-6 alkenyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl-C 1-6 alkyl, C 6-10 aryl, C 6-10 aryl-C 1-6 alkyl, C 3-6 heterocyclyl, C 3-6 heterocyclyl-C 1-6 alkyl and C 2-9 heterocyclyl are optionally substituted by one or more groups selected from C 1-6 alkyl, halogenated C 1-6 alkyl, carboxy, halogen, cyano, nitro, oxo, C 1-4 -alkoxy, C 1-4 haloalkoxy, hydroxy, C 3-6 cycloalkyl-C 1-4 alkoxy, C 3-6 heterocycloalkyl, —(CH 2 ) m —C(═O)NR 7 R 8 , —C(═O)—(CH 2 ) m —NR 7 R 8 , —(CH 2 ) m —S(═O) 2 NR 7 R 8 , —(CH 2 ) m NH—C(═O)NR 7 R 8 , —(CH 2 ) m —N(R 7 )C(═O)R 8 , —(CH 2 ) m —N(R 7 )C(═O)—OR 8 , —(CH 2 ) m —C(═O)—OR 7 , —(CH 2 ) m —C(═O)R 7 , —(CH 2 ) m —S(═O) 2 R 7 , —(CH 2 ) m —O—C(═O)—R 7 , —(CH 2 ) m —R 7 , and —(CH 2 ) m —NR 7 R 8 ;
R 5 is selected from hydrogen and C 1-6 alkyl, C 3-7 -cycloalkyl, C 1-6 heterocyclyl, heteroaryl and C 6-10 aryl, optionally substituted with one or more groups selected from OH, C 1-4 alkoxy, halogenated C 1-4 alkoxy, and halogen;
R 7 and R 8 are independently selected from —H, C 1-6 alkyl, C 6-10 aryl, C 1-5 heterocyclyl, and C 3-6 cycloalkyl-C 0-4 alkyl, wherein said C 1-6 alkyl, C 6-10 aryl, C 1-5 heterocyclyl, and C 3-6 cycloalkyl-C 0-4 alkyl are optionally substituted with one or more groups selected from —OH, methoxy, ethoxy and halogen; and
m is 0, 1, 2 or 3,
with a proviso that at least one of R 1 , R 2 , R 3 and R 4 is not hydrogen.
25 . A method for preparing a compound of formula II,
comprising reacting a compound of formula III with HNR 1 R 2
wherein:
X 1 and X 2 are independently halogens;
R 1 and R 2 are independently selected from hydrogen, C 1-6 alkyl-C(═O)—, C 1-6 alkyl, C 2-6 alkenyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl-C 1-6 alkyl, C 3-7 cycloalkyl fused with a phenyl, C 3-7 cycloalkyl fused with a phenyl and C 2-6 heteroaryl, C 1-14 heterocyclyl, C 1-14 heterocyclyl-C 1-6 alkyl, C 6-10 aryl, C 6-10 aryl-C 1-6 alkyl, or R 1 and R 2 together with the nitrogen connected thereto form a C 2-9 heterocyclyl; wherein said C 1-6 alkyl-C(═O)—, C 1-6 alkyl, C 2-6 alkenyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl-C 1-6 alkyl, C 3-7 cycloalkyl fused with a phenyl, C 1-14 heterocyclyl, C 1-14 heterocyclyl-C 1-6 alkyl, C 6-10 aryl, C 6-10 aryl-C 1-6 alkyl and C 2-9 heterocyclyl are optionally substituted by one or more groups selected from, halogen, cyano, nitro, C 1-6 alkoxy, C 1-4 haloalkoxy, C 1-6 alkyl, halogenated C 1-6 alkyl, C 3-6 -cycloalkyl, C 3-6 cycloalkoxy, C 3-6 cycloalkyl-C 1-4 alkoxy, —(CH 2 ) m —C(═O)NR 7 R 8 , —(CH 2 ) m —S(═O) 2 NR 7 R 8 , —(CH 2 ) m NH—C(═O)NR 7 R 8 , —(CH 2 ) m —N(R 7 )C(═O)R 8 , —(CH 2 ) m —N(R 7 )C(═O)—OR 8 , —(CH 2 ) m —C(═O)—OR 7 —(CH 2 ) m —C(═O)R 7 , —(CH 2 ) m —S(═O) 2 R 7 , —(CH 2 ) m —S(═O)R 7 , —(CH 2 ) m —SR 7 , —(CH 2 ) m —O—C(═O)—R 7 , —(CH 2 ) m —OR 7 , —(CH 2 ) m —NR 7 R 8 hydroxy, C 1-14 heterocyclyl-C 0-4 -alkyl, phenyl, benzyl, phenylethyl, wherein said C 1-14 heterocyclyl-C 0-4 -alkyl, phenyl, benzyl or phenethyl optionally substituted by one or more groups selected from halogen, cyano, nitro, oxo, C 1-6 alkoxy, C 1-4 haloalkoxy, C 1-6 alkyl, halogenated C 1-6 alkyl, C 3-6 -cycloalkyl, C 3-6 cycloalkoxy, —(CH 2 ) m —C(═O)NR 7 R 8 , —C(═O)—(CH 2 ) m —NR 7 R 8 , —(CH 2 ) m —S(═O) 2 NR 7 R 8 , —(CH 2 ) m NH—C(═O)NR 7 R 8 , —(CH 2 ) m —N(R 7 )C(═O)R 8 , —(CH 2 ) m —N(R 7 )C(═O)—OR 8 , —(CH 2 ) m —C(═O)—OR 7 , —(CH 2 ) m —C(═O)R 7 , —(CH 2 ) m —S(═O) 2 R 7 , —(CH 2 ) m —S(═O)R 7 , —(CH 2 ) m —SR 7 , —(CH 2 ) m —O—C(═O)—R 7 , —(CH 2 ) m —OR 7 , —(CH 2 ) m —NR 7 R 8 and hydroxy;
R 5 is selected from hydrogen and C 1-6 alkyl, C 3-7 -cycloalkyl, C 1-6 heterocyclyl, heteroaryl and C 6-10 aryl, optionally substituted with one or more groups selected from OH, C 1-4 alkoxy, halogenated C 1-4 alkoxy, and halogen;
R 7 and R 8 are independently selected from —H, C 1-6 alkyl, C 6-10 aryl, C 1-5 heterocyclyl, and C 3-6 cycloalkyl-C 0-4 alkyl, wherein said C 1-6 alkyl, C 6-10 aryl, C 1-5 heterocyclyl, and C 3-6 cycloalkyl-C 0-4 alkyl are optionally substituted with one or more groups selected from —OH, methoxy, ethoxy and halogen; and
m is 0, 1, 2 or 3.
26 - 28 . (canceled)