Anti-inflammatory and anti-HIV compositions and methods of use
View Patent ↗The metabolic fingerprint and anti-inflammatory activity and anti-HIV activity of H. gentianoides is disclosed. High performance liquid chromatography (HPLC) analysis shows that H. gentianoides contains a family of compounds, including some not previously observed in other Hypericum species. H. gentianoides extracts and fractions from these extracts reduce prostaglandin E2 synthesis in mammalian macrophages and inhibit HIV in infected HeLa cells. The present invention provides extracts and fractions thereof from H. gentianoides for use in pharmaceutical compositions and methods for the treatment or inhibition of inflammation, prostaglandin E-mediated disease, disorder or condition, a cyclooxygenase-mediated disease, disorder or condition, or an HIV infection.
1. A method of treating inflammation in an animal comprising: administering to an animal in need thereof, an effective amount of an isolated acyl-phloroglucinol selected from the group consisting of saroaspidin A, uliginosin A and hyperbrasilol C.
2. The method of claim 1 wherein said acyl-phloroglucinol is isolated from a plant.
3. The method of claim 2 wherein said acyl-phloroglucinol is isolated from a plant of the genus Hypericum.
4. The method of claim 3 wherein said acyl-phloroglucinol is isolated from Hypericum gentianoides.
5. The method of claim 1 wherein said treatment for inflammation includes treatment for joint inflammation.