Nematodes as model organisms for the investigation of neurodegenerative diseases, in particular parkinsons disease, uses and methods for the discovery of substances and genes which can used in the treatment of the above disease states and identification of a nematode gene
The invention relates to nematodes as model organisms for the investigation of neurodegenerative diseases, in particular, Parkinsons disease, uses and methods for the discovery of substances and genes which can be used in the treatment of the above disease states and identification of a nematode gene, From C elegans , which is homologous to the human parkin gene associated with Parkinsons disease. The invention further relates to those nematodes which contain an aberrant or missing expression of at least one gene, preferably a parkin gene and/or a α-synucleine gene, which is connected with Parkinsons disease. According to the invention, the above organisms can be used for the identification and characterization of medicaments for the treatment of said disease states.
1. A genetically modified nematode belonging to the genus Caenorhabditis said nematode expressing human α-synuclein under the control of a Caenorhabditis neuronal promoter, wherein the human α-synuclein is aggregated in Caenorhabditis neurons after expression.
2. The genetically modified nematode of claim 1 further comprising a phenotype associated with the expression of said α-synuclein gene, said phenotype selected from the group consisting of:
a defect in egglaying;
a defect in the formation of the vulva;
a retarded development; and
a decreased number of descendants.