Indole derivatives substituted with long-chain alcohols and medicaments containing them
Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R 1 , R 2 , R 3 and R 4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number from 0 to 20; and a medicinal composition comprising the same. The indole long-chain alcohol (I) exhibits an excellent nerve growth promoting effect, as well as potent antioxidative and anti-tumor effects, and is therefore useful as a prophylactic and/or therapeutic agent for cerebral diseases including dementia diseases, and malignant tumors including brain tumors.
1. A method for treating a cerebral dementia disease comprising:
administering to a patient in need thereof a therapeutically effective amount of an indole long-chain alcohol, according to the following formula (I):
wherein
R 1 , R 2 , R 3 , and R 4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and
n represents a number from 0 to 9.
2. The method according to claim 1 , wherein n represents a number from 0 to 3.
3. The method according to claim 1 , wherein n represents a number from 3 to 5.
4. The method according to claim 1 , wherein n represents a number from 5 to 7.
5. The method according to claim 1 , wherein n represents a number from 7 to 9.
6. The method according to claim 1 , wherein the therapeutically effective amount of the indole long-chain alcohol is from 0.001 to 1000 mg/day.
7. The method according to claim 1 , wherein the therapeutically effective amount of the indole long-chain alcohol is administered either once per day or in two to four divided doses per day.
8. The method according to claim 1 , wherein the therapeutically effective amount of the indole long-chain alcohol is administered orally or parenterally.
9. A method for treating a malignant brain tumor comprising:
administering to a patient in need thereof a therapeutically effective amount of an indole long-chain alcohol, according to the following formula (I):
wherein R 1 , R 2 , R 3 , and R 4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number from 0 to 9.
10. The method according to claim 9 , wherein n represents a number from 0 to 3.
11. The method according to claim 9 , wherein n represents a number from 3 to 5.
12. The method according to claim 9 , wherein n represents a number from 5 to 7.
13. The method according to claim 9 , wherein n represents a number from 7 to 9.
14. The method according to claim 9 , wherein the therapeutically effective amount of the indole long-chain alcohol is from 0.001 to 1000 mg/day.
15. The method according to claim 9 , wherein the therapeutically effective amount of the indole long-chain alcohol is administered either once per day or in two to four divided doses per day.
16. The method according to claim 9 , wherein the therapeutically effective amount of the indole long-chain alcohol is administered orally or parenterally.
17. The method according to claim 1 , wherein said indole long-chain alcohol is administered in combination with a pharmaceutically acceptable carrier.
18. The method according to claim 9 , wherein said indole long-chain alcohol is administered in combination with a pharmaceutically acceptable carrier.