IP Library Granted Patent US 7,982,462
Granted Patent B2
US 7,982,462 · App. 12/135,837 · Granted Jul 19, 2011

System, method and computer accessible medium for magnetic resonance spectroscopic imaging

Assignee: New York University
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Quick Facts
Patent No.
US 7,982,462
App. No.
12/135,837
Granted
Jul 19, 2011
Kind
B2
Abstract

An exemplary embodiment of system, method, and computer accessible medium for magnetic resonance spectroscopic imaging for improving signal-to-noise ratio per unit time and optimizing duty cycle in MRSI and/or for reducing chemical-shift artifacts can be provided. In one exemplary embodiment, an excitation pulse can be forwarded to the target and acquiring a signal from the target by multiplexing in time and space. The multiplexing procedure in time can involve (i) a segmentation of a field of view of the at least one portion of the target into a predetermined number of slabs that are acquired sequentially during each repetition time, and/or (ii) an acquisition of multiple voxels. Data can be generated based on the acquired signal. According to another exemplary embodiment, an excitation pulse can be provided to the target, and a signal can be acquired from the target. The excitation pulse can be a series of cascaded Hadamard pulse components. Data can be generated based on the acquired signal.

Claims (49)

1. A method for generating data associated with at least one portion of a target comprising:

forwarding at least one excitation pulse to the target;

acquiring a signal from the target resulting from the at least one excitation pulse, wherein the signal from the target is acquired by (i) segmenting a field of view of the at least one portion of the target into a predetermined number of slabs that are acquired sequentially during each repetition time, and wherein each of the slabs comprises a plurality of slices, and (ii) multiplexing the slabs in time and the slices in space; and

using a hardware processing arrangement, generating the data based on the acquired signal.

2. The method of claim 1 , wherein the predetermined number (M) is determined as follows: M=TR opt /T c , wherein TR opt is an optimal repetition time and T c is an acquisition cycle.

3. The method of claim 1 , wherein multiplexing in space comprises an acquisition of multiple voxels.

4. The method of claim 3 , wherein repetition time (TR) extends beyond an acquisition cycle of the signal.

5. The method of claim 1 , wherein the target is an anatomical structure.

6. The method of claim 1 , wherein the data is a magnetic resonance readout.

7. The method of claim 1 , wherein the data is image data, and wherein the image data is generated based on the acquired signal.

8. The method of claim 1 , wherein the excitation pulse is forwarded according to a magnetic resonance spectroscopy imaging pulse sequence.

9. The method of claim 1 , wherein the excitation pulse comprises a series of Hadamard pulse components and wherein the pulses components are cascaded.

10. The method of claim 1 , further comprising: at least one of displaying or storing the data in a storage arrangement in at least one of a user-accessible format or a user-readable format.

11. The method of claim 1 , wherein the plurality of slices are multiplexed in space and the predetermined number of slabs are multiplexed in time so that at least one of (i) the slices associated with each slab is proportional to a total number of the slices associated with the at least one portion of the target, or (ii) a total number of the slabs associated with the at least one portion of the target is independent of the total number of the slices associated with the at least one portion of the target.

12. A non-transitory computer accessible medium having stored thereon computer executable instructions for generating data associated with at least a portion of a target which, when the executable instruction are executed by a processing arrangement, configure the processing arrangement to perform a procedure comprising:

forwarding at least one excitation pulse to the target;

acquiring a signal from the target resulting from the at least one excitation pulse, wherein acquiring the signal from the target is performed by (i) segmenting a field of view of the at least one portion of the target into a predetermined number of slabs that are acquired sequentially during each repetition time, and wherein each of the slabs comprises a plurality of slices, and (ii) multiplexing the slabs in time and the slices in space; and

generating the data based on the acquired signal.

13. The computer accessible medium of claim 11 , wherein the predetermined number (M) is determined as follows: M=TR opt /T c , wherein TR opt is an optimal repetition time and T c is an acquisition cycle.

14. The computer accessible medium of claim 12 , wherein multiplexing in space comprises an acquisition of multiple voxels.

15. The computer accessible medium of claim 14 , wherein repetition time (TR) extends beyond an acquisition cycle of the signal.

16. The computer accessible medium of claim 12 , wherein the target is an anatomical structure.

17. The computer accessible medium of claim 12 , wherein the data is a magnetic resonance readout.

18. The computer accessible medium of claim 12 , wherein the data is image data, and wherein the image data is generated based on the acquired signal.

19. The computer accessible medium of claim 12 , wherein the excitation pulse is forwarded according to a magnetic resonance spectroscopy imaging pulse sequence.

20. The computer accessible medium of claim 12 , wherein the plurality of slices are multiplexed in space and the predetermined number of slabs are multiplexed in time so that at least one of (i) the slices associated with each slab is proportional to a total number of the slices associated with the at least one portion of the target, or (ii) a total number of the slabs associated with the at least one portion of the target is independent of the total number of the slices associated with the at least one portion of the target.

21. A method for generating data associated with at least one portion of a target, comprising:

providing at least one excitation pulse to the target, wherein the at least one excitation pulse comprises a series of Hadamard pulse components, and wherein the pulses components are cascaded;

acquiring a signal from the target resulting from the at least one excitation pulse; and

using a hardware processing arrangement, generating the data based on the acquired signal.

22. The method of claim 21 , wherein the signal from the target is acquired by (i) segmenting a field of view of the at least one portion of the target into a predetermined number of slabs that are acquired sequentially during each repetition time, and wherein each of the slabs comprises a plurality of slices, and (ii) multiplexing the slabs in time and the slices in space.

23. The method of claim 22 , wherein multiplexing in space comprises an acquisition of multiple voxels.

24. The method of claim 22 , wherein the target is an anatomical structure.

25. The method of claim 22 , wherein the data is a magnetic resonance readout.

26. The method of claim 22 , wherein the data is image data, and wherein the image data is generated based on the acquired signal.

27. The method of claim 22 , wherein the excitation pulse is forwarded according to a magnetic resonance spectroscopy imaging pulse sequence.

28. The method of claim 21 , wherein the plurality of slices are multiplexed in space and the predetermined number of slabs are multiplexed in time so that at least one of (i) the slices associated with each slab is proportional to a total number of the slices associated with the at least one portion of the target, or (ii) a total number of the slabs associated with the at least one portion of the target is independent of the total number of the slices associated with the at least one portion of the target.

29. The method of claim 21 , further comprising: at least one of displaying or storing the data in a storage arrangement in at least one of a user-accessible format or a user-readable format.

30. A non-transitory computer accessible medium having stored thereon computer executable instructions for generating data associated with at least a portion of a target which, when the executable instruction are executed by a processing arrangement, configure the processing arrangement to perform a procedure, comprising:

providing at least one excitation pulse to the target, wherein the at least one excitation pulse comprises a series of Hadamard pulse components, and wherein the pulses components are cascaded;

acquiring a signal from the target resulting from the at least one excitation pulse; and

generating the data based on the acquired signal.

31. The computer accessible medium of claim 30 , wherein the signal from the target is acquired by (i) segmenting a field of view of the at least one portion of the target into a predetermined number of slabs that are acquired sequentially during each repetition time, and wherein each of the slabs comprises a plurality of slices, and (ii) multiplexing the slabs in time and the slices in space.

32. The computer accessible medium of claim 31 , wherein multiplexing in space comprises an acquisition of multiple voxels.

33. The computer accessible medium of claim 29 , wherein the plurality of slices are multiplexed in space and the predetermined number of slabs are multiplexed in time so that at least one of (i) the slices associated with each slab is proportional to a total number of the slices associated with the at least one portion of the target, or (ii) a total number of the slabs associated with the at least one portion of the target is independent of the total number of the slices associated with the at least one portion of the target.

34. The computer accessible medium of claim 30 , wherein the target is an anatomical structure.

35. The computer accessible medium of claim 30 , wherein the data is a magnetic resonance readout.

36. The computer accessible medium of claim 30 , wherein the data is image data, and wherein the image data is generated based on the acquired signal.

37. The computer accessible medium of claim 30 , wherein the excitation pulse is forwarded according to a magnetic resonance spectroscopy imaging pulse sequence.

Assignments (4)
CONFIRMATORY LICENSE Recorded Mar 27, 2015
From: NEW YORK UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 035279/0513 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 19, 2011
From: GOELMAN, GADI; GONEN, ODED
To: NEW YORK UNIVERSITY
Reel/Frame 026778/0518 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 11, 2008
From: GOELMAN, GADI; GONEN, ODED
To: NEW YORK UNIVERSITY
Reel/Frame 021966/0226 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 9, 2008
From: GONEN, ODED; GOELMAN, GADI
To: NEW YORK UNIVERSITY
Reel/Frame 021068/0167 →
Continuity (2)
Provisional Application 60942694 · Jun 8, 2007
Related Publication 20090085564A1 · Apr 2, 2009