Pulsatile flux drug delivery

1. A method of treating a mammal comprising the steps of:

a. introducing a catheter into a distensible tissue of a mammal, said catheter being operably connected to a drug delivery pump, and

b. intermittently operating said drug delivery pump for one or more predetermined intervals of time to generate a pulsatile flux of drug through said catheter into said tissue,

wherein said time intervals of intermittent pump operation allow sufficient time for said distensible tissue to recoil around said catheter, thereby preventing backflow of said drug along an outer wall of said catheter.

2. The method of claim 1 , wherein said one or more predetermined time intervals of pump operation are comprised of equal intervals of operational and non-operational time intervals.

3. The method of claim 1 , wherein said one or more predetermined time intervals of pump operation are comprised of non-equal time intervals of operational and non-operational time intervals.

4. The method of claim 3 wherein the non-operational time intervals are greater than the operational time intervals.

5. The method of claim 1 , wherein said one or more predetermined time intervals of pump operation are comprised of two or more different intervals of non-operational time intervals.

6. The method of claim 1 , wherein said one or more predetermined time intervals of pump operation are comprised of two or more different time intervals of pump operation.

7. The method of claim 1 , wherein said one or more predetermined time intervals of pump operation are comprised of two or more different intervals of operational time intervals and two or more non-operational time intervals.

8. The method of claim 1 , wherein said one or more predetermined time intervals of pump operation are repetitively performed to generate a pulsatile flux of drug exiting the catheter into said tissue.

9. The method of claim 1 further comprised of the step of controlling the flux exiting the catheter by altering a number and size of ports on said catheter.

10. The method of claim 1 wherein said distensible tissue is selected from the group consisting of brain, liver, kidney, lung, spleen, and pancreatic tissue.

11. The method of claim 10 wherein said distensible tissue is brain tissue.

12. A method of treating a mammal comprising the steps of:

a. introducing a catheter into a distensible tissue of a mammal, said catheter being operably connected to a drug delivery pump, and

b. operating said drug delivery pump at two or more predetermined rates of flow over two or more predetermined time intervals to generate a pulsatile flux of drug through said catheter into said tissue,

wherein the combination of said two or more predetermined rates of flow over two or more predetermined time intervals allow sufficient time for said distensible tissue to recoil around said catheter, thereby preventing backflow of said drug along an outer wall of said catheter.

13. The method of claim 12 wherein said distensible tissue is selected from the group consisting of brain, liver, kidney, lung, spleen, and pancreatic tissue.

14. The method of claim 13 wherein said distensible tissue is brain tissue.