N-oxides of venlafaxine and o-desmethylvenlafaxine as prodrugs
Embodiments of the invention relate to a compound of formula (1), or a tautomer, stereoisomer, hydrate, or solvate thereof, wherein R 1 is H or CH 3 . Other embodiments of the invention relate to a pharmaceutical composition containing these compound, to methods for preparing these compounds, and to methods for preparing compositions containing these compounds. Yet other embodiments of the invention relate to the uses of these compounds and compositions containing it, such as for the manufacture of medicaments and pharmaceutical compositions for treating a condition chosen from depression, major depressive disorder, generalized anxiety disorder, obsessive compulsive disorder, social anxiety disorder, panic disorder, general depressive disorders, diabetic neuropathy, migraine and hot flashes.
1. A compound of formula (1):
or a tautomer or stereoisomer thereof, wherein the asterisk (*) marks the asymmetric carbon atom, wherein R 1 is CH 3 .
2. The compound as claimed in claim 1 , wherein the compound is the (R)-enantiomer.
3. The compound as claimed in claim 1 , wherein the compound is the (S)-enantiomer.
4. A medicament comprising a compound of formula (1):
or a tautomer or stereoisomer thereof, wherein the asterisk (*) marks the asymmetric carbon atom, wherein R 1 is CH 3 .
5. A pharmaceutical composition comprising, at least one pharmaceutically acceptable carrier, at least one pharmaceutically acceptable auxiliary substance, or a combination thereof, and at least one compound of formula (1):
or a tautomer or stereoisomer thereof, wherein the asterisk (*) marks the asymmetric carbon atom, wherein R 1 is CH 3 .
6. A combination pharmaceutical preparation comprising:
(i) a compound of formula (1):
or a tautomer or stereoisomer thereof, wherein the asterisk (*) marks the asymmetric carbon atom, wherein R 1 is CH 3 , and
(ii) a second therapeutic agent, for simultaneous, separate or sequential use in treating a condition chosen from depression, major depressive disorder, generalized anxiety disorder, obsessive compulsive disorder, social anxiety disorder, panic disorder, general depressive disorders, diabetic neuropathy, migraine and hot flashes, wherein treating includes at least one of inhibiting the condition, relieving the condition, or stopping the symptoms of the condition.
7. The combination pharmaceutical preparation as claimed in claim 6 , wherein said second therapeutic agent is venlafaxine or O-demethylvenlafaxine.
8. A method for treating a condition chosen from depression, major depressive disorder, generalized anxiety disorder, obsessive compulsive disorder, social anxiety disorder, panic disorder, general depressive disorders, diabetic neuropathy, migraine and hot flashes, said method comprising administering a composition comprising compound of formula (1):
or a tautomer or stereoisomer thereof, wherein the asterisk (*) marks the asymmetric carbon atom, wherein R 1 is CH 3 , in a human or animal patient in need of such treating, wherein treating includes at least one of inhibiting the condition, relieving the condition, or stopping the symptoms of the condition.
9. A process for preparing a pharmaceutical composition comprising:
(i) combining a compound of formula (1):
or a tautomer or stereoisomer thereof, wherein the asterisk (*) marks the asymmetric carbon atom, wherein R 1 is CH 3 , with at least one pharmaceutically acceptable carrier, at least one pharmaceutically auxiliary substance, or a combination thereof; and
(ii) formulating the combination produced in (i) into a suitable dosage form.
10. A process for preparing a combination preparation comprising:
(i) combining a compound of formula (1):
or a tautomer or stereoisomer thereof, wherein the asterisk (*) marks the asymmetric carbon atom, wherein R 1 is CH 3 , a second therapeutic agent, and at least one pharmaceutically acceptable carrier, at least one pharmaceutically auxiliary substance, or a combination thereof; and
(ii) formulating the combination produced in (i) into a suitable dosage form.
11. A process for preparing a compound of formula (1):
or a tautomer or stereoisomer thereof, wherein the asterisk (*) marks the asymmetric carbon atom, wherein R 1 is CH 3 , the process comprising reacting a compound of formula (a) with an oxidizing agent: