Titanate nanowire, titanate nanowire scaffold, and processes of making same
View Patent ↗In one aspect, the present invention relates to a synthetic nanostructure. In one embodiment, the synthetic nanostructure has a top region substantially comprising titanate nanowires, a middle region substantially comprising titanate nanoparticles and titanate nanowires, and a bottom region substantially comprising titanium, wherein some of the titanate nanowires of the top region are extending into the middle region, wherein the middle region is between the top region and the bottom region, and wherein some of the titanate nanowires of the top region are substantially perpendicular to the bottom surface of the titanium substrate. At least some of the titanate nanowires in the top region form 3D macroporous scaffolds with interconnected macropores.
1. A synthetic nanostructure, comprising:
(a) a top region comprising titanate nanowires;
(b) a middle region comprising titanate nanoparticles and titanate nanowires;
(c) a bottom region comprising titanium and having a bottom surface,
wherein the titanate nanowires are solid and are formed at a reaction temperature not less than about 180 ° C.,
wherein the middle region is between the top region and the bottom region, and some of the titanate nanowires of the top region are substantially perpendicular to the bottom surface of the bottom region and extending into the middle region, and
wherein some of the titanate nanowires in the middle region are vertically rooted on corresponding titanate nanoparticles and extend from the corresponding titanate nanoparticles in a downward direction that is substantially perpendicular to the bottom surface of the bottom region.
2. The synthetic nanostructure of claim 1 , wherein at least some of the titanate nanowires in the top region form 3D macroporous scaffolds with interconnected macropores.
3. The synthetic nanostructure of claim 1 , wherein the bottom region comprises a titanium substrate that is selected from the group consisting of commercially pure titanium, a titanium alloy, and a titanium compound, and wherein the bottom surface of the titanium substrate is the bottom surface of the bottom region.
4. The synthetic nanostructure of claim 1 , wherein the bottom region comprises a titanium substrate having morphology selected from the group consisting of foil, plate, wire, mesh, grid, sphere, and tube, and wherein the bottom surface of the titanium substrate is the bottom surface of the bottom region.
5. The synthetic nanostructure of claim 1 , wherein the titanate nanowires have an average diameter ranging from about 10 nm to about 100 nm and an average length ranging from about 1 μm to about 1 mm.
6. The synthetic nanostructure of claim 2 , wherein the interconnected macropores have an average diameter ranging from about 2 to about 10 μm when the average nanowire length is about 5 μm.
7. The synthetic nanostructure of claim 1 , wherein the thickness of the middle region ranges from about 4 to about 30 μm.
8. The synthetic nanostructure of claim 2 , further comprising a therapeutic molecule within one or more of the macropores.
9. A synthetic nanostructure, comprising a plurality of titanate nanowires formed on a titanium substrate having a top surface and a bottom surface, wherein at least some of the plurality of titanate nanowires form 3D macroporous scaffolds with interconnected macropores, and further comprising three regions:
(a) a top region comprising titanate nanowires;
(b) a middle region comprising titanate nanoparticles and titanate nanowires; and
(c) a bottom region comprising titanium,
wherein the titanate nanowires are solid and formed at a reaction temperature not less than about 180 ° C.,
wherein some of the titanate nanowires of the top region are extending into the middle region, and substantially perpendicular to the bottom surface of the titanium substrate, and
wherein some of the titanate nanowires in the middle region are vertically rooted on corresponding titanate nanoparticles and extend from the corresponding titanate nanoparticles in a downward direction that is substantially perpendicular to the bottom surface of the titanium substrate.
10. The synthetic nanostructure of claim 9 , wherein the titanium substrate is selected from the group consisting of commercially pure titanium, a titanium alloy, and a titanium compound.
11. The synthetic nanostructure of claim 9 , wherein the titanium substrate has morphology selected from the group consisting of foil, plate, wire, mesh, grid, sphere, and tube, wherein the substrate may be any size.
12. The synthetic nanostructure of claim 9 , wherein the titanate nanowires have an average diameter ranging from about 10 nm to about 100 nm and an average length ranging from about 1 μm to about 1 mm.
13. The synthetic nanostructure of claim 9 , wherein the interconnected macropores have an average diameter ranging from about 2 to about 10 μm when the average nanowire length is about 5 μm.
14. The synthetic nanostructure of claim 9 , wherein the thickness of the middle region ranges from about 4 to about 30 μm.
15. The synthetic nanostructure of claim 9 , further comprising a therapeutic molecule, wherein the therapeutic molecule is substantially within the macropores.