Drug activation process and vibrational mill therefor
The invention comprises a process for activating drugs by means of high-energy co-grinding of the drug with a pharmaceutical carrier, characterized by the use of a vibrational mill equipped with means that regulate the vibration frequency. The process, performed by modifying the frequency of vibration and keeping its amplitude constant, produces drug/carrier composites with a constant particle size in which the degree of drug activation increases in proportion to the frequency applied. The invention also includes a vibrational mill suitably modified to perform the process described.
1. A method for activating a drug in pharmaceutical composites having particles of constant size, comprising subjecting a drug and a pharmaceutical carrier to co-grinding in a vibrational mill equipped with means to regulate vibration frequency while vibration amplitude is kept constant, wherein drug activation degree increases in proportion to the vibration frequency applied while particle size remains constant.
2. The method of claim 1 wherein said vibrational mill includes a motor and said vibration frequency is varied by varying a rotational speed of said motor.
3. The method of claim 2 wherein said rotational speed is between 200 and 4500 rpm.
4. The method of claim 2 wherein said rotational speed is between 500 and 4000 rpm.
5. The method of claim 2 wherein said rotational speed is between 700 and 3500 rpm.
6. The method of claim 1 further comprising providing a potentiometer connected to said vibrational mill, said potentiometer being adapted to determine said vibration frequency of said vibrational mill.
7. The method of claim 6 wherein said potentiometer is adapted to communicate said vibration frequency to an operator.
8. The method of claim 1 , wherein the vibration frequency is between 200 and 4500 rpm.
9. The method of claim 1 , wherein the vibration frequency is between 500 and 4000 rpm.
10. The method of claim 1 , wherein the vibration frequency is between 700 and 3500 rpm.
11. The method of claim 1 , wherein the said means designed to regulate the vibration frequency is a potentiometer connected to the motor of the mill, which can be suitably regulated by an operator.
12. The method of 1 , wherein the drug and carrier are used, optionally pre-mixed, in proportions of between 12:1 and 0.5:1 by weight.