IP Library › Granted Patent US 8,895,507
Granted Patent B2
US 8,895,507 · App. 12/148,166 · Granted Nov 25, 2014

Modulation of synaptogenesis

Inventors: Ben A. Barres (Palo Alto, CA); Cagla Eroglu (Burlingame, CA)
Assignee: The Board of Trustees of the Leland Stanford Junior University
A61K38/1709G01N33/5058C07K14/4702G01N33/5032G01N2333/4727A61K38/39
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Quick Facts
Patent No.
US 8,895,507
App. No.
12/148,166
Granted
Nov 25, 2014
Kind
B2
Abstract

Soluble proteins, e.g. Hevin, can trigger synapse formation; and other soluble proteins, e.g. SPARC antagonize this activity. Such proteins are synthesized in vitro and in vivo by astrocytes. Methods are provided for protecting or treating an individual suffering from adverse effects of deficits in synaptogenesis, or from undesirably active synaptogenesis.

Claims (5)

1. A method of enhancing synaptogenesis in an individual with glaucoma comprising the step of:

contacting a retinal ganglion cell in an individual with glaucoma with an effective dose of a SEQ ID NO:1 polypeptide; wherein the number of synapses is increased in said retinal ganglion cell relative to a retinal ganglion cell that is not contacted with a SEQ ID NO:1 polypeptide.

2. The method of claim 1 , wherein the SEQ ID NO:1 polypeptide comprises residues 16-431 of SEQ ID NO:1.

3. The method of claim 1 , further comprising administration of neural progenitors.

4. The method of claim 1 , wherein the increased number of synapses is measured as a recovery of sensory abilities.

Assignments (3)
CONFIRMATORY LICENSE Recorded Jan 12, 2015
From: STANFORD UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 034750/0813 →
CONFIRMATORY LICENSE Recorded Mar 27, 2009
From: STANFORD UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 022462/0669 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 11, 2008
From: BARRES, BEN A.; EROGLU, CAGLA
To: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Reel/Frame 021082/0148 →
Continuity (2)
Provisional Application 60923940 · Apr 16, 2007
Related Publication 20090029909A1 · Jan 29, 2009