Method for the preparation of (
A method of preparation of (S)-N-methyl-3-(1-naphthyloxy)-3-(2-mienyl)propylamine of Formula (I) and its pharmaceutically acceptable salts, comprising a) reaction of (RS)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine with optically active D-tartaric acid or an acid salt derived from D-tartaric acid forming a mixture of diastereoisomeric salts of N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine and D-tartaric acid (2:1), b) isolation of the salt (S)-N,N-dimethyl-3-(naphthyloxy) -3-(2-thienyl)propylamine/D-tartrate (2:1) from the mixture of diastereoisomeric salts in an organic solvent, water or a mixture thereof and release of (S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine by action of an inorganic or organic base, c) demethylation of (S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine by action of an alkylchloroformate of formula ClCOOR (R=C 1 -C 5 alkyl, or C 6 -C 12 aryl or alkylraryl), especially phenyl, ethyl or methyl chloroformate, and d) hydrolytic release of the duloxetine base of formula I and optionally conversion of the base to a salt with the respective acid, or salt of a weak base.
1. A method of preparation of (S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine of formula I
and its pharmaceutically acceptable salts, comprising
a) reaction of (RS)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine of formula III
with optically active D-tartaric acid or an acid salt derived from D-tartaric acid forming a mixture of diastereoisomeric salts of N,N-dimethyl-3-(1-naphthyloxy)-3-(2- thienyl) propylamine and D-tartaric acid (2:1),
b) isolation of the salt (S)-N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl) propylamine/D-tartrate (2:1) from the mixture of diastereoisomeric salts in an organic solvent, water or a mixture thereof and release of (S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine of formula (S)-(III) by action of an inorganic or organic base
c) demethylation of (S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-hienyl)propylamine by action of an alkylchloroformate of formula ClCOOR, wherein R is a C 1 -C 5 alkyl, or C 6 -C 12 aryl or alkylaryl, and
d) hydrolytic release of the duloxetine base of formula I and optionally conversion of the base to a salt with the respective acid, or salt of a weak base,
wherein the optically active substance in step (a) is D-tartaric acid in the molar ratio 1:2 relative to the substance of formula III, an alkali metal acid D-tartrate, ammonium tartrate, or alkylammonium tartrate of formula IV
in the molar ratio 1:1 relative to the substance of formula III.
2. The method according to claim 1 , wherein the reaction in step a) is performed in the presence of water.
3. The method according to claim 2 , wherein the reaction is performed in a solvent mixture composed of water and a polar aprotic solvent in a 2-fold to 10-fold (by volume) excess of water relative to the polar aprotic solvent.
4. The method according to claim 3 , wherein the polar aprotic solvent is dimethylsulfoxide.
5. The method according to claim 1 , wherein one uses, in step (b), for isolation of the salt (S)-N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl)propylamine/D-tartrate (2:1) from the mixture of diastereoisomeric salts, a solvent selected from the group of aliphatic and cyclic ethers, C 3 -C 6 ketones, C 1 -C 3 alcohols and water, or a mixture therof, and a temperature of from 0 to 80° C.
6. The method according to claim 5 , wherein the solvent is an aqueous solution of THF containing from 0 to 10% of water.
7. The method according to claim 1 , wherein in step (d), the substance of formula I is converted to its hydrochloride via reaction with hydrochloric acid in an environment of the solvent ethylmethylketone and the obtained duloxetine hydrochloride is crystallized from said solvent.
8. The method according to claim 1 , wherein R is phenyl, ethyl or methyl.