Antiseptic alginate preparation
An antiseptic preparation is provided for the production of wound dressings or bandages. The preparation includes at least one alginate and at least one antiseptically active substance selected from the group biguanide derivatives, octenidine and taurolidine. Processes for the production of the antiseptic preparations, and the use thereof, are also provided.
1. An antiseptic alginate preparation for production of a wound dressing, the preparation comprising calcium alginate fibers that are impregnated with at least one antiseptically active substance selected from the group consisting of polyhexamethylene biguanide and salts of polyhexamethylene biguanide, wherein the at least one antiseptically active substance is present in the antiseptic alginate preparation in an amount of 0.5% to 10% by weight relative to a dry weight of the antiseptic alginate preparation, and wherein the antiseptic activity of the antiseptically active substance is not inactivated by the presence of the calcium alginate fibers.
2. The preparation according to claim 1 , wherein the at least one antiseptically active substance is water-soluble.
3. The preparation according to claim 1 , wherein the preparation comprises at least one additional material selected from the group consisting of collagen-based materials, pectin, cellulose and cellulose derivatives, synthetic fibers, and superabsorbers.
4. The preparation according to claim 3 , wherein the additional material is present in an amount of 5 to 50 wt. %, relative to a weight of non-antiseptically active substances of the preparation.
5. The preparation according to claim 3 , wherein the additional material is present in an amount of 50 to 95 wt. %, relative to a weight of non-antiseptically active substances of the preparation.
6. The preparation according to claim 1 , wherein the preparation has a form selected from fibers, fiber composites, textile fabrics, solutions, gels, and lyophilizates.
7. A process for preparing an antiseptic alginate preparation, the process comprising:
impregnating calcium alginate fibers with at least one antiseptically active substance selected from the group consisting of polyhexamethylene biguanide and salts of polyhexamethylene biguanide, wherein the impregnating step comprises one of the following:
spraying, soaking or dripping the calcium alginate fibers, or products made from the calcium alginate fibers, with a solution of the at least one antiseptically active substance; and
obtaining the calcium alginate fibers from a precipitation bath containing the at least one antiseptically active substance;
and subsequently drying the calcium alginate fibers,
wherein the at least one antiseptically active substance is present in the obtained antiseptic alginate preparation in an amount of 0.5% to 10% by weight relative to a dry weight of the antiseptic alginate preparation, and wherein the antiseptic activity of the antiseptically active substance is not inactivated by the presence of the calcium alginate fibers.
8. The process according to claim 7 , wherein drying is effected by lyophilization.
9. The preparation according to claim 1 , wherein the preparation is present in one of a wound dressing and a bandage material.
10. A wound dressing or bandage comprising an antiseptic alginate preparation, the preparation comprising calcium alginate fibers that are impregnated with at least one antiseptically active substance selected from the group consisting of polyhexamethylene biguanide and salts of polyhexamethylene biguanide, wherein the at least one antiseptically active substance is present in the antiseptic alginate preparation in an amount of 0.5% to 10% by weight relative to a dry weight of the antiseptic alginate preparation, and wherein the antiseptic activity of the antiseptically active substance is not inactivated by the presence of the calcium alginate fibers.
11. The preparation according to claim 1 , wherein the calcium alginate fibers are impregnated with polyhexamethylene biguanide hydrochloride.
12. The preparation according to claim 1 , wherein the preparation exhibits antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa , and Candida albicans.
13. The process according to claim 7 , wherein the at least one antiseptically active substance comprises polyhexamethylene biguanide hydrochloride.
14. The preparation according to claim 1 , wherein the calcium alginate fibers are present in an amount of 50% to 95% by weight relative to a weight of non-antiseptically active substances.
15. The wound dressing or bandage according to claim 10 , wherein the calcium alginate fibers are present in an amount of 50% to 95% by weight relative to a weight of non-antiseptically active substances.
16. The preparation according to claim 1 consisting of calcium alginate fibers impregnated with polyhexamethylene biguanide, wherein polyhexamethylene biguanide is present in an amount of 0.5% to 10% by weight relative to a dry weight of the calcium alginate fibers.
17. The wound dressing or bandage according to claim 10 , wherein the antiseptic alginate preparation consists of calcium alginate fibers impregnated with polyhexamethylene biguanide, wherein polyhexamethylene biguanide is present in an amount of 0.5% to 10% by weight relative to a dry weight of the calcium alginate fibers.