Medical adhesives for surgery
The present invention relates to novel, rapidly curing adhesives based on hydrophilic polyisocyanate prepolymers for use in surgery.
1. A process for the closure or binding of cellular tissues, comprising applying at least one adhesive system comprising
A) prepolymers comprising isocyanate groups obtained from
A1) aliphatic isocyanates; and
A2) polyols with number-averaged molecular weights of ≧400 g/mol and average OH group contents of from 2 to 6;
and
B) amino group-containing aspartate esters of general formula (I)
wherein
X is an n-valent organic radical obtained by removal of the primary amino groups of an n-functional amine;
R 1 and R 2
are, identically or differently, organic radicals comprising no Zerevitinov active hydrogen; and
n is a whole number of at least 2;
and/or
C) reaction products of prepolymers comprising isocyanate groups with aspartate
esters according to B)
to the cellular tissue to be closed or bound.
2. The process of claim 1 , wherein said aliphatic isocyanates in A1) have only aliphatically or cycloaliphatically bound isocyanate groups.
3. The process of claim 1 , wherein said aliphatic isocyanates in A1) have an average NCO group content of from 2 to 2.4.
4. The process of claim 1 , wherein said polyols in A2) have number-averaged molecular weights of from 4000 to 8500 g/mol.
5. The process of claim 1 , wherein said polyols in A2) have average OH group contents of from 3 to 4.
6. The process of claim 1 , wherein A2) comprises polyalkylene oxide polyethers.
7. The process of claim 6 , wherein said polyalkylene oxide polyethers have a content of ethylene oxide-based units of from 60 to 90% based on the total quantity of alkylene oxide units contained in said polyalkylene oxide polyethers.
8. The process of claim 1 , wherein X is derived from 4-diaminobutane, 1,6-diaminohexane, 1,5-diaminopentane, or 2-methyl-1,5-diaminopentane as n-functional amines; R 1 and R 2 are, independently of one another, a C 1 to C 10 alkyl radical; and n is 2.
9. The process of claim 1 , wherein said two-component adhesive system does not comprise B).
10. The process of claim 1 , wherein said reaction products of C) are obtained by reaction of said prepolymers with said aspartate esters in a ratio of isocyanate-reactive groups to isocyanate groups of between 15 to 1 and 4 to 1.
11. The process of claim 1 , wherein said cellular tissue is human or animal tissue.