Skin care compositions
Dermatological and cosmetic compositions and methods are provided to reduce the appearance of biological and/or environmentally-caused aging.
1. A topical cosmetic or dermatological composition for human use comprising:
(a) one or more growth factors, wherein the one or more growth factors comprise a Transforming Growth Factor;
(b) at least two acylated peptides wherein one of said acylated peptides is a myristoylated peptide and the other acylated peptide is a palmitoylated peptide; and
(c) optionally, at least one skin benefit agent selected from the group consisting of antioxidants, humectants and moisturizing agents.
2. The composition of claim 1 wherein the one or more growth factors further comprise an Epidermal Growth Factor.
3. The compositions of claim 1 wherein the one or more growth factors are one or more recombinant growth factors.
4. The composition of claim 2 wherein the Epidermal Growth Factor is a human Epidermal Growth Factor.
5. The composition of claim 1 wherein the one or more growth factors further comprise one or more Fibroblast Growth Factors.
6. The composition of claim 1 wherein the one or more growth factors further comprise a Keratinocyte Growth Factor.
7. The composition of claim 6 wherein the Keratinocyte Growth Factor is a human Keratinocyte Growth Factor.
8. The composition of claim 6 wherein the Keratinocyte Growth Factor is KGF-1.
9. The composition of claim 6 wherein the Keratinocyte Growth Factor is KGF-2.
10. The composition of claim 1 wherein the Transforming Growth Factor-β1 is a human Transforming Growth Factor-β1.
11. The composition of claim 1 wherein the one or more growth factors further comprise a Vascular Endothelial Growth Factor.
12. The composition of claim 11 wherein the Vascular Endothelial Growth Factor is a human Vascular Endothelial Growth Factor.
13. The composition of claim 1 further comprising a third acylated peptide and optionally four or more acylated peptides.
14. The composition of claim 1 further comprising at least one antioxidant.
15. The composition of claim 14 wherein the at least one antioxidant is ubiquinone.
16. The composition of claim 14 wherein the at least one antioxidant is green tea extract.
17. The composition of claim 14 wherein the at least one antioxidant is tocopherol acetate.
18. The composition of claim 1 further comprising one or more humectants.
19. The composition of claim 18 wherein said one or more humectants are selected from the group consisting of D,L-panthenol, D-panthenol, sodium hyaluronate, methylsilanol mannuronate and butylene glycol.
20. The composition of claim 2 wherein the Epidermal Growth Factor comprises from about 0.000001% w/w to about 0.001% w/w of the composition.
21. The composition of claim 20 wherein the Epidermal Growth Factor comprises from about 0.00001% w/w to about 0.001% w/w of the composition.
22. The composition of claim 5 wherein the Fibroblast Growth Factor comprises from about 0.000001% to about 0.01% w/w of the composition.
23. The composition of claim 22 wherein the Fibroblast Growth Factor comprises from about 0.000001% w/w to about 0.0001% w/w of the composition.
24. The composition of claim 6 wherein the Keratinocyte Growth Factor comprises from about 0.000001% to about 0.01% w/w of the composition.
25. The composition of claim 24 wherein the Keratinocyte Growth Factor comprises from about 0.000001% w/w to about 0.0001% w/w of the composition.
26. The composition of claim 1 wherein the Transforming Growth Factor-β1 comprises from about 0.000001% w/w to about 0.01% w/w of the composition.
27. The composition of claim 26 wherein the Transforming Growth Factor-β1 comprises from about 0.000001% w/w to about 0.0001% w/w of the composition.
28. The composition of claim 11 wherein the Vascular Endothelial Growth Factor comprises from about 0.000001% w/w to about 0.001% w/w of the composition.
29. The composition of claim 1 wherein the myristoylated peptide comprises from about 0.001% w/w to about 2.0% w/w of the composition and the palmitoylated peptide comprises from about 0.500% w/w to about 6.00% w/w of the composition.
30. The composition of claim 1 further comprising at least two humectants.
31. A topical cosmetic or dermatological composition for human use comprising:
(a) an Epidermal Growth Factor;
(b) a Keratinocyte Growth Factor;
(c) a Transforming Growth Factor-β1;
(d) at least one myristoylated peptide;
(e) at least one antioxidant;
at least one humectant or moisturizing agent; and
(g) a cosmetically suitable vehicle.
32. A method for improving the appearance of skin comprising topically applying the composition of claim 1 to the skin.
33. A method for improving the appearance of skin comprising topically applying the composition of claim 31 to the skin.
34. The composition of claim 31 wherein the Epidermal Growth Factor comprises from about 0.000001% w/w to about 0.001% w/w of the composition.
35. The composition of claim 34 wherein the Epidermal Growth Factor comprises from about 0.00001% w/w to about 0.001% w/w of the composition.
36. The composition of claim 31 wherein the Kerotinocyte Growth Factor comprises from about 0.000001% w/w to about 0.01% w/w of the composition.
37. The composition of claim 31 wherein the Kerotinocyte Growth Factor comprises from about 0.000001% w/w to about 0.0001% w/w of the composition.
38. The composition of claim 31 wherein the Transforming Growth Factor-01 comprises from about 0.000001% w/w to about 0.01% w/w of the composition.
39. The composition of claim 31 wherein the Transforming Growth Factor-β1 comprises from about 0.000001% w/w to about 0.0001% w/w of the composition.
40. The composition of claim 31 wherein the myristoylated peptide comprises from about 0.001% w/w to about 2.0% w/w of the composition.
41. The composition of claim 31 wherein:
(a) the Epidermal Growth Factor comprises from about 0.000001% w/w to about 0.001% w/w of the composition;
(b) the Kerotinocyte Growth Factor comprises from about 0.000001% w/w to about 0.01% w/w of the composition;
(c) the Transforming Growth Factor-β1 comprises from about 0.000001% w/w to about 0.01% w/w of the composition; and
(d) the myristoylated peptide comprises from about 0.001% w/w to about 2.0% w/w of the composition.