Anti-CD79B antibodies and immunoconjugates and methods of use
The present invention is directed to anti-CD79b antibody, huMA79b.v28, and compositions of matter thereof useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
1. An antibody which binds to CD79b comprising:
(i) an HVR-L1 sequence of KASQSVDYEGDSFLN (SEQ ID NO: 194)
(ii) an HVR-L2 sequence of AASNLES (SEQ ID NO: 195)
(iii) an HVR-L3 sequence of QQSNEDPLT (SEQ ID NO: 196)
(iv) an HVR-H1 sequence of GYTFSSYWIE (SEQ ID NO: 202)
(v) an HVR-H2 sequence of GEILPGGGDTNYNEIFKG (SEQ ID NO: 203), and
(vi) an HVR-H3 sequence of TRRVPIRLDY (SEQ ID NO: 204).
2. An antibody of claim 1 comprising the heavy chain variable domain sequence of SEQ ID NO: 208.
3. An antibody of claim 1 comprising the light chain variable domain sequence of SEQ ID NO: 207.
4. An antibody of claim 1 comprising the heavy chain variable domain sequence of SEQ ID NO: 208 and the light chain variable domain sequence of SEQ ID NO: 207.
5. A composition comprising the antibody of any of claim 1 , 2 , 3 or 4 .