IP Library › Granted Patent US 8,858,946
Granted Patent B2
US 8,858,946 · App. 12/179,399 · Granted Oct 14, 2014

Method for inhibiting HIV-1 replication utilizing anti-GBV-C E2 antibodies

Inventors: Jack T. Stapleton (Iowa City, IA); Jinhua Xiang (Iowa City, IA); Donna Klinzman (Coralville, IA); James H. McLinden (Coralville, IA)
Assignees: The University of Iowa Research Foundation; The United States of America, as represented by the Secretary of the Department of Veterans Affairs
C07K16/109C07K2317/34A61K2039/505
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Quick Facts
Patent No.
US 8,858,946
App. No.
12/179,399
Granted
Oct 14, 2014
Kind
B2
Abstract

GB virus C (GBV-C or hepatitis G virus) is a flavivirus that frequently leads to chronic viremia in humans. The invention provides compositions and methods involving an anti-GBV-C antibody or other GBV-C binding agent, or a GBV-C antigen, for inhibiting and treating HIV infections.

Claims (8)

1. A method for inhibiting HIV-1 replication comprising providing to a subject an anti-GBV-C E2 antibody, wherein the antibody attenuates HIV-1 infectivity.

2. The method of claim 1 , wherein the antibody is a human antibody.

3. The method of claim 1 , wherein the antibody is a monoclonal antibody.

4. The method of claim 3 , wherein the antibody is a humanized antibody.

5. The method of claim 1 , further comprising administration of at least a second anti-HIV therapy.

6. The method of claim 5 , wherein the second anti-HIV-1 therapy is HAART therapy.

7. The method of claim 5 , wherein the second anti-HIV-1 therapy is AZT therapy.

8. The method of claim 1 , wherein the antibody is provided at least twice.

Assignments (3)
CONFIRMATORY LICENSE Recorded Nov 3, 2014
From: UNIVERSITY OF IOWA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 034117/0135 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 4, 2013
From: STAPLETON, JACK T.; XIANG, JINHUA; KLINZMAN, DONNA; MCLINDEN, JAMES H.
To: THE UNIVERSITY OF IOWA RESEARCH FOUNDATION; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMEN OF VETERANS AFFAIRS
Reel/Frame 030539/0627 →
CONFIRMATORY LICENSE Recorded Apr 22, 2009
From: UNIVERSITY OF IOWA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 022578/0228 →
Continuity (3)
Division 10862061 · Jun 4, 2004
Provisional Application 60475987 · Jun 5, 2003
Related Publication 20090010932A1 · Jan 8, 2009