DEUTERIUM-ENRICHED MK-0812

1 . A deuterium-enriched compound of formula I or a pharmaceutically acceptable salt thereof:

wherein R 1 -R 34 are independently selected from H and D; and

the abundance of deuterium in R 1 -R 34 is at least 3%.

2 . A deuterium-enriched compound of claim 1 , wherein the abundance of deuterium in R 1 -R 34 is selected from at least 3%, at least 6%, at least 12%, at least 18%, at least 24%, at least 29%, at least 35%, at least 41%, at least 47%, at least 53%, at least 59%, at least 65%, at least 71%, at least 76%, at least 82%, at least 88%, at least 94%, and 100%.

3 . A deuterium-enriched compound of claim 1 , wherein the abundance of deuterium in R 1 is selected from at least 100%.

4 . A deuterium-enriched compound of claim 1 , wherein the abundance of deuterium in R 2 -R 9 is selected from at least 13%, at least 25%, at least 38%, at least 50%, at least 63%, at least 75%, at least 88%, and 100%.

5 . A deuterium-enriched compound of claim 1 , wherein the abundance of deuterium in R 10 -R 23 is selected from at least 7%, at least 14%, at least 21%, at least 29%, at least 36%, at least 43%, at least 50%, at least 57%, at least 64%, at least 71%, at least 79%, at least 86%, at least 93%, and 100%.

6 . A deuterium-enriched compound of claim 1 , wherein the abundance of deuterium in R 24 -R 31 is selected from at least 13%, at least 25%, at least 38%, at least 50%, at least 63%, at least 75%, at least 88%, and 100%.

7 . A deuterium-enriched compound of claim 1 , wherein the abundance of deuterium in R 32 -R 34 is selected from at least 33%, at least 67%, and 100%.

8 . A deuterium-enriched compound of claim 1 , wherein the compound is selected from compounds 1-6 of Table 1.

9 . A deuterium-enriched compound of claim 1 , wherein the compound is selected from compounds 7-12 of Table 2.

10 . An isolated deuterium-enriched compound of formula I or a pharmaceutically acceptable salt thereof:

wherein R 1 -R 34 are independently selected from H and D; and

the abundance of deuterium in R 1 -R 34 is at least 3%.

11 . An isolated deuterium-enriched compound of claim 10 , wherein the abundance of deuterium in R 1 -R 34 is selected from at least 3%, at least 6%, at least 12%, at least 18%, at least 24%, at least 29%, at least 35%, at least 41%, at least 47%, at least 53%, at least 59%, at least 65%, at least 71%, at least 76%, at least 82%, at least 88%, at least 94%, and 100%.

12 . An isolated deuterium-enriched compound of claim 10 , wherein the abundance of deuterium in R 1 is selected from at least 100%.

13 . An isolated deuterium-enriched compound of claim 10 , wherein the abundance of deuterium in R 2 -R 9 is selected from at least 13%, at least 25%, at least 38%, at least 50%, at least 63%, at least 75%, at least 88%, and 100%.

14 . An isolated deuterium-enriched compound of claim 10 , wherein the compound is selected from compounds 1-6 of Table 1.

15 . An isolated deuterium-enriched compound of claim 10 , wherein the compound is selected from compounds 7-12 of Table 2.

16 . A mixture of deuterium-enriched compounds of formula I or a pharmaceutically acceptable salt thereof:

wherein R 1 -R 34 are independently selected from H and D; and

the abundance of deuterium in R 1 -R 34 is at least 3%.

17 . A mixture of deuterium-enriched compound of claim 16 , wherein the compound is selected from compounds 1-6 of Table 1.

18 . A mixture of deuterium-enriched compound of claim 16 , wherein the compound is selected from compounds 7-12 of Table 2.

19 . A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt form thereof.

20 . A method for treating a disease selected from rheumatoid arthritis, multiple sclerosis, and/or atherosclerosis comprising: administering, to a patient in need thereof, a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt form thereof.