Coating with antimicrobial agents
A coating with antimicrobial agents for use with medical devices. In one approach, a related method involves coating high temperature vulcanized silicone material with a room temperature vulcanized dispersion.
1. A method for coating a material with active drugs, comprising:
incorporating an active drug into a first material of silicone elastomer that is uncured;
stirring the active drug and the first material of silicone elastomer at 80° C. until a uniform color and uniform consistency is reached;
forming a coating composition including the active drug and the uncured material;
applying the coating composition to a second cured material of silicone elastomer, wherein the first material is the most external layer, and without swelling the cured silicone elastomer material.
2. The method of claim 1 , wherein the first uncured material is an uncured RTV silicone elastomer.
3. The method of claim 2 , wherein the second material is a cured HTV silicone elastomer.
4. The method of claim 1 , wherein the active drug is one or more of Rifampin and Minocycline.
5. The method of claim 1 , comprising coating in an amount to provide an effective concentration to prevent bacterial colonization.
6. The method of claim 5 , comprising coating a medical device.
7. The method of claim 6 , comprising coating a portion of a breast implant.
8. The method of claim 6 , comprising incorporating the active drug into an external layer of a silicone elastomer sheath of the device.
9. The method of claim 1 , comprising dissolving or dispersing the active drug into an organic solvent to form an antimicrobial solution or dispersion.
10. The method of claim 9 , wherein the organic solvent is one or more of acetic acid and xylene.
11. The method of claim 9 , comprising incorporating the antimicrobial solution or dispersion into an uncured RTV silicone elastomer dispersion to form a mixture.
12. The method of claim 11 , comprising applying the mixture onto cured HTV silicone elastomer surface of the device.
13. The method of claim 12 , comprising curing the uncured silicone elastomer.
14. The method of claim 13 , comprising curing for about 60 to 180 minutes at a temperature of 90 to 200 degrees Fahrenheit.