Prostaglandin analog compositions and methods to treat epithelial-related conditions
The present invention relates to the formulation and delivery of prostaglandin analogs to treat epithelial-related condition. In some embodiments, the compositions of the invention are used to stimulate hair growth. In some embodiments, the compositions of the invention are used to restore hair color to depigmented hair.
1. A method for treating an epithelial-related condition wherein the epithelial-related condition is a condition selected from the group consisting of sparse hair growth, short hair growth, thin hair growth, and hair de-pigmentation, the method comprising the steps:
(a) preparing at least one compound of formula III or a salt of formula III:
wherein
the simple straight line represents a bond lying approximately in the surface plane; the wedge shaped bond is directed to the front of surface plane; and the hatched bond is directed in the back of the surface plane; and
wherein the compound has optically active isomers whenever chiral centers are present; and
(b) formulating a composition comprising the at least one compound of step (a) and a carrier; and
(c) topically applying onto an epithelial surface of a subject, including a human, in need thereof, a cosmetically effective amount of the composition; and
(d) stimulating hair growth.
2. The method according to claim 1 , wherein the at least one compound of formula III is 17-phenyl trinor PGF 2α cyclopropyl methyl amide.
3. The method according to claim 1 , wherein the composition is an ophthalmic composition.
4. The method according to claim 1 , further comprising the step of restoring pigmentation to depigmented hair.
5. The method according to claim 1 , wherein the epithelial-related condition is alopecia.
6. The method according to claim 1 , wherein the epithelial surface onto which the composition is applied topically is an eyelid.
7. The method according to claim 1 , wherein the epithelial-related condition is alopecia of at least one eyelash.
8. The method according to claim 1 , wherein the epithelial surface onto which the composition is applied topically is a face.
9. The method according to claim 1 , wherein the condition is alopecia of at least one eyebrow.
10. The method according to claim 1 , wherein the epithelial surface onto which the composition is applied topically is a scalp.
11. The method according to claim 1 , wherein the epithelial surface onto which the composition is applied topically is above a lip.