Multifunctional Antioxidants and methods of use thereof
View Patent ↗Compositions comprising multifunctional agents and methods of use thereof are provided. Particularly, a series of analogs of 1-N, N′-dimethylsulfamoyl-4-(2-pyrimidyl)piperazine are provided which are useful for treating and/or preventing cataract, macular degeneration, neurodegenerative disorders, and/or injury or symptoms associated with radiation exposure.
1. A compound of the formula:
wherein R 1 is =O or comprises two moieties independently selected from the group consisting of H, halo, thiol, carboxy, nitro, amino, cyano, hydroxyl, alkyl, and aryl, wherein R 2 is selected from the group consisting of H, halo, thiol, carboxy, nitro, amino, cyano, hydroxyl, alkyl, and aryl, and wherein R 3 is OH.
2. The compound of claim 1 , wherein at least one R 2 is selected from the group consisting of H, halo, thiol, carboxy, nitro, amino, cyano, hydroxyl, and a lower alkyl.
3. The compound of claim 1 , wherein at least one R 1 is =O.
4. The compound of claim 1 , wherein at least one R 1 is H, H or =O; and at least one R 2 is selected from the group consisting of H, —R, —OR, —SR, and —NHR, wherein R is H or a lower alkyl.
5. The compound of claim 1 , wherein at least one R 1 is =O; and at least one R 2 is selected from the group consisting of H, —R, —OR, —SR, and —NHR, wherein R is H or a lower alkyl.
6. The compound of claim 1 , wherein both R 1 groups are H,H and both R 2 groups are H.
7. The compound of claim 1 , wherein both R 1 groups are =O and both R 2 groups are H.
8. The compound of claim 1 , wherein both R 1 groups are H, H and both R 2 groups are —OCH 3 .
9. The compound of claim 1 , wherein both R 1 groups are =O and both R 2 groups are —OCH 3 .
10. A composition comprising at least one compound of claim 1 and at least one pharmaceutically acceptable carrier.