Methods for treatment of cancer
A method for treating or preventing cancer in a subject comprising administering a treatment effective amount of a chemotype 4 compound.
1. A method for treating cancer in which cancerous cells express MUC1* in a subject comprising assaying for presence of MUC1* in the cancer cells, and administering a treatment effective amount of a compound comprised of the formula below to the subject in which cancer cells express MUC1*:
or a steroisomer, tautomer, pharmaceutically acceptable salt, or ester thereof, wherein,
R3 is carbocycloalkyl;
R4 is selected from alkyl, branched alkyl, cycloalkyl, and H; and
R5 is halogen, lower alkyl, haloalkyl, alkylether, —NH 2 , mono-substituted amine, di-substituted amine, cyclic amine, or H.
2. The method according to claim 1 , wherein R5 is selected from halogen, lower alkyl, haloalkyl, alkylether, and H.
3. The method according to claim 1 , wherein R5 is H, F, Cl, OCH 3 , CH 3 , CN, NO 2 , or NH 2 .
4. The method according to claim 1 , wherein R5 is selected from H, F, and Cl.
5. The method according to claim 1 , wherein R5 is H.
6. A method for treating cancer in which cancerous cells express MUC1* in a subject comprising assaying for presence of MUC1* in the cancer cells, and administering a treatment effective amount of a compound comprised of the formula below to the subject in which cancer cells express MUC1*:
or a steroisomer, tautomer, pharmaceutically acceptable salt, or ester thereof, wherein,
R3 is carbocycloalkyl;
R4 is selected from alkyl, branched alkyl, cycloalkyl, and H;
R5 is halogen, lower alkyl, haloalkyl, alkylether, —NH 2 , mono-substituted amine, di-substituted amine, cyclic amine, or H;
R6 is H or alkyl;
R7 is H or alkyl; and
R8 is H or alkyl.
7. The method according to claim 6 , wherein R5 is selected from halogen, lower alkyl, haloalkyl, alkylether, and H.
8. The method according to claim 6 , wherein R5 is H, F, Cl, OCH 3 , CH 3 , CN, NO 2 , or NH 2 .
9. The method according to claim 6 , wherein
R5 is H, F, or Cl;
R6 is H or CH 3 ;
R7 is H or CH 3 ; and
R8 is H or CH 3 .
10. The method according to claim 6 , wherein
R5 is H;
R6 is H;
R7 is H; and
R8 is H.
11. The method according to claim 1 , wherein R5 is is morpholine, pyrrolidine, piperazine or piperidine.
12. The method according to claim 1 , wherein R5 is —OCH 3 .
13. The method according to claim 2 , wherein R5 is F, Cl, Br or I.
14. The method according to claim 2 , wherein R5 is CF3.
15. The method according to claim 2 , wherein R5 is methyl, ethyl or propyl.
16. The method according to claim 6 , wherein R5 is morpholine, pyrrolidine, piperazine or piperidine.
17. The method according to claim 6 , wherein R5 is —OCH 3 .
18. The method according to claim 7 , wherein R5 is CF3.
19. The method according to claim 7 , wherein R5 is methyl, ethyl or propyl.
20. The method according to claim 7 , wherein R5 is —OCH 3 .