Methods of treating cancer by administering antibodies to CD200
Methods and compositions for regulating immunity are disclosed. For enhancing an immune response, agents that inhibit OX-2 are administered. Such methods are useful in treating cancer. For suppressing an immune response, an OX-2 protein or a nucleic acid encoding an OX-2 protein is administered. Such methods are useful in preventing graft rejection, fetal loss, autoimmune disease, allergies and in inducing tumor cell growth.
1. A method of inhibiting or reducing leukemia cell growth comprising administering an effective amount of an antibody that binds to and inhibits a CD200 protein to a cell or an animal in need thereof.
2. A method of inhibiting or reducing leukemia cell growth comprising: determining whether CD200 is upregulated in a subject; and administering to the subject an antibody that binds to and inhibits CD200.
3. A method according to claim 2 wherein the step of administering an antibody comprises administering to the subject a monoclonal antibody that binds to and inhibits CD200.
4. A method of treating a leukemia comprising: determining whether CD200 is upregulated in a subject afflicted with leukemia; and administering to the subject an antibody that binds to and inhibits CD200.
5. A method as in claim 4 wherein the step of administering an antibody comprises administering to the subject a monoclonal antibody that binds to and inhibits CD200.
6. A method according to claim 1 wherein the antibody comprises a humanized antibody.
7. A method according to claim 1 wherein the antibody comprises an Fv, scFv, Fab′ or F(ab′)2 fragment.
8. A method according to claim 2 wherein the antibody comprises a humanized antibody.
9. A method according to claim 2 wherein the antibody comprises an Fv, scFv, Fab′ or F(ab′)2 fragment.
10. A method according to claim 4 wherein the antibody comprises a humanized antibody.
11. A method according to claim 4 wherein the antibody comprises an Fv, scFv, Fab′ or F(ab′)2 fragment.
12. A method according to claim 1 further comprising administering a chemotherapeutic agent.