METHOD FOR AMELIORATING OF POST-ANESTHETIC RECOVERY
The invention describes use of injectable form of Idebenone to improve recovery after general anesthesia and of cognitive functions, suppress disorientation and other signs of neuronal damage.
1 . Method of treatment or prevention of post-operative cognitive dysfunction (POCD) syndrome or delirium and improvement in post-anesthesia recovery by the parenteral administration of a pharmaceutical composition, comprising at least one physiologically acceptable ubiquinone.
2 - 6 . (canceled)
7 . A method as set forth in claim 1 wherein said ubiquinone is 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone (Idebenone).
8 . A method as set forth in claim 1 wherein said composition is administrated parenterally via intravenous injection, intravenous infusion, intra-arterial, intramuscular, subcutaneous or intra-peritoneal injection.
9 . A method as set forth in claim 7 wherein said Idebenone is administrated in doses from 0.5 to 50 mg/kg per day.
10 . A method as set forth in claim 1 wherein said composition is a colloidal delivery system, selected from micellar preparations, emulsions, solid lipid nanoparticles or suspensions, wherein said ubiquinone is associated with the hydrophobic phase of the colloidal system.
11 . A method as set forth in claim 10 wherein said colloidal delivery system is an oil-in-water emulsion.