Immunoglobulin variants and uses thereof
The invention provides humanized and chimeric anti-CD20 antibodies for treatment of CD20 positive malignancies and autoimmune diseases.
1. A method of treating multiple sclerosis, comprising administering to a patient suffering from multiple sclerosis, a therapeutically effective amount of a humanized antibody that binds human CD20 or an antigen-binding fragment thereof, wherein the antibody comprises the V H sequence of SEQ ID NO.8 and the V L sequence of SEQ ID NO.2.
2. The method of claim 1 , wherein the antibody or the antigen-binding fragment is administered at a dosage selected from 2×10 mg, 2×50 mg, 2×200 mg and 2×500 mg.
3. The method of claim 1 , wherein the antibody or the antigen-binding fragment is administered by intravenous infusion.
4. The method of claim 1 , wherein the antibody comprises the heavy chain and light chain amino acid sequences of SEQ ID NO. 39 and 40, respectively.
5. The method of claim 1 , wherein the antibody comprises the light chain and heavy chain amino acid sequences of SEQ ID NO. 40 and 41, respectively.
6. The method of claim 1 , wherein the antibody or the antigen-binding fragment is administered subcutaneously.