Wise binding agents and epitopes
The present invention relates to binding agents for WISE, and includes for their manufacture and use.
1. An isolated antibody or fragment thereof that binds WISE, wherein the heavy chain of said antibody comprises SEQ ID NO: 24.
2. An antibody or fragment thereof according to claim 1 in combination with one or more of a pharmaceutically acceptable excipient, diluent or carrier.
3. An antibody or fragment thereof according to claim 1 conjugated to at least one of Fc, PEG, albumin, and transferrin.
4. An antibody or fragment thereof of claim 1 comprising a light chain selected from the group consisting of SEQ ID NOs: 22, 46, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 116, 118, 120, and 122.
5. An antibody or fragment thereof of claim 1 that inhibits WISE activity.