IP Library › Granted Patent US 8,232,098
Granted Patent B2
US 8,232,098 · App. 12/283,347 · Granted Jul 31, 2012

p49/STRAP is a novel protein involved in gene regulation and cell proliferation

Assignees: The Board of Trustees of the University of Arkansas; The United States of America as represented by the Department of Veterans Affairs
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Quick Facts
Patent No.
US 8,232,098
App. No.
12/283,347
Granted
Jul 31, 2012
Kind
B2
Abstract

The invention provides isolated p49/STRAP protein, and isolated nucleic acids encoding a p49/STRAP protein. The inventors have discovered a new protein, named p49/STRAP that is expressed in cardiac tissue and other tissues in mammals. The p49/STRAP protein binds to serum response factor (SRF) and regulates transcription of SRF-responsive genes in the heart. p49/STRAP is also discovered to inhibit tumor cell proliferation, and thus the invention provides a method of inhibiting cancer cell proliferation by contacting the cells with p49/STRAP.

Claims (3)

1. An isolated nucleic acid comprising a p49/STRAP gene and adapted to express a p49/STRAP protein from the p49/STRAP gene in a recombinant host cell; wherein the p49/STRAP gene encodes a protein at least 90% identical to SEQ ID NO:1 or at least 90% identical to SEQ ID NO:2.

2. The isolated nucleic acid of claim 1 wherein the p49/STRAP gene encodes a protein at least 90% identical to SEQ ID NO:2.

3. The isolated nucleic acid of claim 1 wherein the p49/STRAP gene encodes a protein at least 90% identical to SEQ ID NO:1.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 20, 2019
From: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
To: BIOVENTURES, LLC
Reel/Frame 051071/0811 →
CONFIRMATORY LICENSE Recorded Jun 29, 2012
From: UNIVERSITY OF ARKANSAS MED SCIS LTL ROCK
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 028466/0277 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 30, 2009
From: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
To: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS; THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
Reel/Frame 022180/0220 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 30, 2009
From: WEI, JEANNE Y.; ZHANG, XIAOMIN
To: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
Reel/Frame 022180/0288 →
Continuity (4)
Continuation 11726699 · Mar 22, 2007
Division 11225270 · Sep 13, 2005
Provisional Application 60610070 · Sep 15, 2004
Related Publication 20090035850A1 · Feb 5, 2009