Granted Patent
B2
US 8,309,528 · App. 12/299,852 · Granted Nov 13, 2012
Two pore channels as regulators of proliferation in cancer
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Abstract
The present invention relates to the discovery that two pore K+ channel (2PK) gene expression is increased in tumors and tumor cell lines, especially prostate tumor cells. The present invention encompasses methods for disease diagnosis, drug screening and the treatment of cancer.
Claims (2)
1. A method of reducing proliferation of cancer cells overexpressing TREK-1, comprising contacting the cancer cell with a nucleic acid sequence encoding a dominant negative TREK-1 ion selectivity filter.
2. The method of claim 1 wherein the cancer is selected from the group comprising prostate cancer, bladder cancer, breast cancer, and colon cancer.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 22, 2011
From: FEINMARK, STEVEN J.; ROBINSON, RICHARD B
To: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Reel/Frame 026483/0532 →
CONFIRMATORY LICENSE
Recorded Sep 29, 2010
From: COLUMBIA UNIVERSITY NEW YORK MORNINGSIDE
To: US ARMY, SECRETARY OF THE ARMY
Reel/Frame 025059/0836 →
Continuity (3)
Provisional Application
60799486
· May 10, 2006
Provisional Application
60835336
· Aug 2, 2006