Method of stimulating the motility of the gastrointestinal system using ipamorelin
The present invention provides a method of stimulating the motility of the gastrointestinal system in a subject in need thereof, wherein the subject suffers from maladies (i.e., disorders, diseases, conditions, or drug- or surgery-induced dysfunction) of the gastrointestinal system, by administering to the subject a ghrelin mimetic, or pharmaceutically acceptable salt thereof. The invention also provides a method of treating a gastrointestinal malady by co-administering a ghrelin mimetic with a laxative, a H 2 receptor antagonist, a serotonin receptor agonist, pure or mixed, an antacid, an opioid antagonist, a proton pump inhibitor, a motilin receptor agonist, dopamine antagonist, a cholinergic agonist, a cholinesterase inhibitor, somatostatin, octreotide, or any combination thereof.
1. A method of treating opioid-induced gastroparesis in a human subject in need thereof comprising administering to said subject a therapeutically effective amount of a compound represented by the structural Formula I:
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the subject is using an opioid for post-surgical pain management.
3. The method of claim 1 , wherein the subject is using an opioid for chronic pain management.
4. The method of claim 3 , wherein the opioid is selected from the group consisting of morphine, codeine, oxycodone, hydromorphone, hydrocodone, methadone, and fentanyl.
5. The method of claim 1 , wherein the compound is administered in a manner in order to achieve an effective plasma concentration.
6. A method of stimulating the motility of the gastrointestinal system in a human subject suffering from opioid-induced gastroparesis comprising administering to said subject a therapeutically effective amount of a compound represented by the structural Formula I:
or a pharmaceutically acceptable salt thereof.
7. The method of claim 6 , wherein the compound is administered in a manner to achieve an effective plasma concentration.
8. The method of claim 1 , consisting essentially of administering said compound or a pharmaceutically acceptable salt thereof.
9. The method of claim 6 , consisting essentially of administering said compound or a pharmaceutically acceptable salt thereof.
10. The method of claim 1 , wherein said administration is via injection.
11. The method of claim 6 , wherein said administration is via injection.