Eye therapy system
Heat is generated in corneal fibrils in a cornea of an eye according to a selected pattern. The heat causes the corneal fibrils corresponding to the selected pattern to transition from a first structure to a second structure. The second structure provides a desired reshaping of the cornea. A cross-linking agent is then activated in the region of corneal fibrils according to the selected pattern. The cross-linking agent prevents the corneal fibrils from changing from the second structure. Thus, embodiments stabilize corneal tissue and improve its biomechanical strength after desired structural changes have been achieved in the corneal tissue. Accordingly, the embodiments help to preserve the desired reshaping of the cornea.
1. A method for applying therapy to an eye, comprising:
generating heat to corneal fibrils in a cornea of an eye according to a selected pattern, the heat causing the corneal fibrils corresponding to the selected pattern to transition from a first structure to a second structure, the second structure providing a reshaping of the cornea; and
activating a cross-linking agent in the region of corneal fibrils according to the selected pattern, the cross-linking agent preventing the corneal fibrils from changing from the second structure.
2. The method according to claim 1 , further comprising applying the cross-linking agent in the region of corneal fibrils according to the selected pattern.
3. The method according to claim 2 , wherein applying the cross-linking agent according to the selected pattern comprises removing corneal epithelium according to the selected pattern and applying the cross-linking agent directly to the region of corneal fibrils below the epithelium.
4. The method according to claim 3 , wherein the initiating element comprises ultraviolet light.
5. The method according to claim 3 , wherein applying the initiating element according to the selected pattern comprises applying a mask, the mask limiting application of the initiating element according to the selected pattern.
6. The method according to claim 3 , wherein applying the initiating element according to the selected pattern comprises applying at least one optical device, the at least one optical device directing the initiating element to the eye according to the selected pattern.
7. The method according to claim 3 , wherein the cross-linking agent is Riboflavin.
8. The method according to claim 1 , wherein activating the cross-linking agent according to the selected pattern comprises applying an initiating element to the region of the corneal fibrils according to the selected pattern, the initiating element activating the cross-linking agent.
9. The method according to claim 1 , further comprising before the step of generating the heat, applying the cross-linking agent in the region of corneal fibrils.
10. The method according to claim 1 , further comprising applying heat-sensitive liposomes containing the cross-linking agent to the region of corneal fibrils.
11. The method according to claim 1 , wherein the step of applying the heat-sensitive liposomes occurs before the step of generating the heat, the heat causing release of the cross-linking agent from the heat-sensitive liposomes.
12. The method according to claim 1 , wherein the cross-linking agent comprises at least one of fibril associated collagens with interrupted triple helices (FACIT collagens) and leucine-rich repeat (LRR) proteoglycans.
13. The method according to claim 1 , wherein the cross-linking agent is in an ophthalmic solution or an ophthalmic ointment.