Microwave heating of aqueous samples on a micro-optical-electro-mechanical system
View Patent ↗Apparatus for heating a sample includes a microchip; a microchannel flow channel in the microchip, the microchannel flow channel containing the sample; a microwave source that directs microwaves onto the sample for heating the sample; a wall section of the microchannel flow channel that receives the microwaves and enables the microwaves to pass through wall section of the microchannel flow channel, the wall section the microchannel flow channel being made of a material that is not appreciably heated by the microwaves; a carrier fluid within the microchannel flow channel for moving the sample in the microchannel flow channel, the carrier fluid being made of a material that is not appreciably heated by the microwaves; wherein the microwaves pass through wall section of the microchannel flow channel and heat the sample.
1. A micro-optical-electro-mechanical system apparatus for heating a sample, comprising:
a microchip;
a microchannel flow channel in said microchip, said microchannel flow channel including a wall section made of silicon or glass;
a chilled emulsifier carrier fluid source connected to said microchannel flow channel that introduces a chilled emulsifier carrier fluid into said microchannel flow channel,
a microreactor maker connected to said microchannel flow channel that produces microreactors containing the sample and introduces said microreactors containing the sample into said microchannel flow channel and into said chilled emulsifier carrier fluid, a microwave source that directs 18 to 26 GHz microwaves onto the sample in said microreactors in said microchannel flow channel for heating the sample in said microreactors; and
a heating area in said microchannel flow channel, said heating area including said wall section made of silicon or glass;
said microwave source being positioned to direct said 18 to 26 GHz microwaves to said heating area and said wall section of said microchannel flow channel so that said wall section of said microwave flow channel receives said 18 to 26 GHz microwaves and said wall section of said microwave flow channel enables said 18 to 26 GHz microwaves to pass through said wall section of said microchannel flow channel in said heating area to the sample in said microreactors, wherein said wall section of said microchannel flow channel is made of silicon or glass that does not absorb said 18 to 26 GHz microwaves and is not heated;
wherein said chilled emulsifier carrier fluid within said microchannel flow channel moves said microreactors containing the sample in said microchannel flow channel, wherein said chilled emulsifier carrier fluid does not absorb said 18 to 26 GHz microwaves and is not heated by said microwaves; wherein said 18 to 26 GHz microwaves pass through said wall section of said microchannel flow channel and heat the sample in said microreactors.
2. The micro-optical-electro-mechanical system apparatus for heating a sample of claim 1 wherein said microreactor maker that produces microreactors containing the sample is a droplet maker that produces microreactors and wherein said microreactors are droplets containing the sample and wherein said microreactor maker directs said microreactors containing the sample into said microchannel flow channel.
3. The micro-optical-electromechanical system apparatus for heating a sample of claim 1 wherein said chilled emulsifier carrier fluid source connected to said microchannel flow channel that introduces a chilled emulsifier carrier fluid into said microchannel flow channel is a chilled emulsifier carrier fluid source that includes a chilled emulsifier wherein said chilled emulsifier carrier fluid source directs said chilled emulsifier into said microchannel flow channel.
4. A method of heating a pie on a microchip, comprising the steps of:
providing a microchannel flow channel in the microchip said microchannel flow channel having a wall section made of silicon or glass and a heating area proximate said wall section;
providing a chilled emulsifier carrier fluid source connected to said microchannel flow channel that introduces a chilled emulsifier carrier fluid into said microchannel flow channel in the microchip,
providing a microreactor maker connected to said microchannel flow channel that produces microreactors containing the sample and introduces said microreactors containing the sample into said microchannel flow channel thereby positioning said microreactors containing the sample within said microchannel flow channel and in said chilled emulsifier carrier fluid in said heating area proximate said wall section,
heating the sample by providing a microwave source that produces 18 to 26 GHz microwaves and positioning said microwave source so that said microwave source directs said 18 to 26 GHz microwaves to said heating area proximate said wall section by directing said 18 to 26 GHz microwaves through said wall section of said microchannel flow channel onto said microreactors containing the sample for heating the sample;
wherein said microchannel flow channel with a wall section receives said 18 to 26 GHz microwaves and enables said 18 to 26 GHz microwaves to pass through said wall section of said microchannel flow channel and said wall section does not absorb said 18 to 26 GHz microwaves and wherein said said microreactors containing the sample within said microchannel flow channel receive said 18 to 26 GHz microwaves and the sample in said microreators is heated by said 18 to 26 GHz microwaves; and
wherein said chilled emulsifier carrier fluid in said microchannel flow channel moves said microreactors containing the sample in said microchannel flow channel wherein said chilled emulsifier carrier fluid does not absorb said 18 to 26 GHz microwaves and is not heated by said microwaves.