IP Library Granted Patent US 8,144,958
Granted Patent B2
US 8,144,958 · App. 12/331,874 · Granted Mar 27, 2012

Medical systems and methods

Assignee: Carl Zeiss Meditec AG
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Quick Facts
Patent No.
US 8,144,958
App. No.
12/331,874
Granted
Mar 27, 2012
Kind
B2
Abstract

This disclosure generally relates to medical systems and methods. In one aspect of the invention, a method includes determining a fluorescent light intensity at one or more points on each of multiple recorded images, and producing an image based on the determined fluorescent light intensity at the one or more points.

Claims (49)

1. A method, comprising:

providing a plurality of images of tissue of a subject;

determining a fluorescent light intensity at one or more points in each of the plurality of the images of the tissue of the subject; and

producing an image based on the determined fluorescent light intensity at the one or more points in each of the plurality of images of the tissue of the subject.

2. The method of claim 1 , further comprising recording the plurality of images of the tissue of the subject.

3. The method of claim 1 , wherein determining the fluorescent light intensity at the one or more points in each of the plurality of images comprises analyzing each of the plurality of images.

4. The method of claim 1 , further comprising displaying the image based on the determined fluorescent light intensity at the one or more points in each of the plurality of images of the tissue of the subject.

5. The method of claim 1 , wherein determining the fluorescent light intensity at the one or more points in each of the plurality of images comprises determining a maximum fluorescent light intensity at the one or more points in each of the plurality of images.

6. The method of claim 5 , wherein the image that is produced based on the determined fluorescent intensity at the one or more points in each of the plurality of images of the tissue of the subject is a representation of the maximum fluorescent intensity determined at the one or more points.

7. The method of claim 6 , wherein the one or more points in each of the plurality of images comprises multiple points in each of the plurality of images.

8. The method of claim 7 , wherein the maximum fluorescent light intensity at each of the multiple points is represented by a brightness, and the brightness increases as the maximum fluorescent light intensity increases.

9. The method of claim 1 , further comprising determining a time at which a predetermined fluorescent light intensity was reached at each of the one or more points.

10. The method of claim 9 , wherein the image that is produced based on the determined fluorescent intensity at the one or more points in each of the plurality of images of the tissue of the subject represents an amount of time for each of the one or more points to reach the predetermined fluorescent light intensity after introducing a fluorescent substance into the tissue of the subject.

11. The method of claim 10 , wherein the amount of time required for each of the one or more points to reach the predetermined fluorescent light intensity after introducing the fluorescent substance into the tissue of the subject is represented by a color on the produced image.

12. The method of claim 11 , wherein the one or more points in each of the plurality of images comprises multiple points in each of the plurality of images.

13. The method of claim 12 , wherein the greatest amount of time required to reach the predetermined fluorescent light intensity among the multiple points is represented as a first color, and the least amount of time required to reach the predetermined fluorescent light intensity among the multiple points is represented as a second color that is different than the first color.

14. The method of claim 1 , wherein the image that is produced based on the determined fluorescent intensity at the one or more points in each of the plurality of images of the tissue of the subject comprises a graph illustrating the determined fluorescent intensity at the one or more points over a period of time.

15. The method of claim 14 , wherein the one or more points in each of the plurality of images comprises multiple points in each of the plurality of images.

16. The method of claim 1 , wherein the plurality of images of the tissue of the subject are recorded by a camera.

17. The method of claim 16 , wherein the plurality of images of the tissue of the subject are analyzed by a microprocessor connected to the camera.

18. The method of claim 1 , wherein the tissue of the subject comprises a blood vessel of the subject.

19. The method of claim 18 , further comprising introducing a fluorescent substance into the blood vessel.

20. The method of claim 19 , further comprising applying light having a wavelength of 400 nm to 780 nm to the blood vessel.

21. The method of claim 20 , wherein the plurality of images are recorded with a fluorescent light camera.

22. The method of claim 1 , wherein the plurality of images are analyzed by a processor.

23. The method of claim 1 , wherein the multiple points in each of the plurality of images comprise all of the points in each of the plurality of images.

24. The method of claim 1 , further comprising treating the tissue of the subject.

25. The method of claim 24 , wherein the plurality of images are images of the tissue of the subject before the tissue of the subject is treated.

26. The method of claim 25 , further comprising determining a fluorescent light intensity at one or more points in each of a second plurality of images of the tissue of the subject after treatment of the tissue of the subject; and producing an image based on the determined fluorescent light intensity at the one or more points in each of the plurality of images of the tissue of the subject.

27. The method of claim 26 , further comprising comparing the produced images to assess the success of the treatment.

28. A system, comprising:

a computer system comprising

a processor for executing instructions; and

memory storing a non-transitory computer program product which, when executed by the processor, performs a method comprising:

providing a plurality of images of tissue of a subject;

determining a fluorescent light intensity at one or more points in each of the plurality of images of the tissue of the subject; and

producing an image based on the determined fluorescent light intensity at the one or more points in each of the plurality of images of the tissue of the subject.

29. The system of claim 28 , further comprising a camera adapted to record the plurality of images of the tissue of the subject.

30. The system of claim 28 , further comprising a display adapted to display the image based on the fluorescent intensity at the one or more points.

31. The system of claim 30 , wherein the processor is adapted to transmit to the display a signal containing the image based on the fluorescent intensity at the one or more points.

32. The system of claim 28 , wherein the processor is adapted to adjust the series of images so that corresponding points in each of the images are aligned with one another.

33. The system of claim 28 , further comprising a fluorescent light source that can be arranged to direct fluorescent light to the site.

34. The system of claim 28 , wherein the system is an operating microscope.

35. The system of claim 28 , wherein the computer program product is software.

36. A system, comprising:

a non-transitory computer program product to:

provide a plurality of images of tissue of a subject;

determine a fluorescent light intensity at one or more points in each of the plurality of images of the tissue of the subject; and

produce an image based on the determined fluorescent light intensity at the one or more points in each of the plurality of images of the tissue of the subject.

Assignments (3)
TRADE REGISTER Recorded Feb 29, 2012
From: CARL ZEISS SURGICAL GMBH
To: CARL ZEISS MEDITEC AG
Reel/Frame 027786/0425 →
MERGER Recorded Feb 29, 2012
From: CARL ZEISS SURGICAL GMBH
To: CARL ZEISS MEDITEC AG
Reel/Frame 027786/0444 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 3, 2009
From: NAHM, WERNER; GUCKLER, ROLAND; HOLZHAUER, THOMAS
To: CARL ZEISS SURGICAL GMBH
Reel/Frame 022195/0222 →
Continuity (2)
Provisional Application 61191748 · Sep 11, 2008
Related Publication 20100061604A1 · Mar 11, 2010