Compositions and methods for inhibiting cell migration
The finding that Dickkopf1 (Dkk1) is a dual function protein demonstrates a mechanism for the coordination of cell migration and antagonism of Wnt/β-catenin signaling during developmental and pathological processes. The profile of Dkk proteins expressed by human breast cancers correlates with indicators of outcome: Dkk1 associates with markers of poor prognosis whereas expression of single function Dkk2 or Dkk3 (which inhibit Wnt/β-catenin signaling and promote migration, respectively) correlates with phenotypes reflective of good prognosis. Therefore, the pro-migratory activities of Dkk1 and 3 identified here offer new insights into breast cancer progression and a potential avenue for therapeutic intervention.
1. A method of mobilizing cells comprising contacting the cells with an effective amount of a Dickkopf-1 (Dkk1) protein selected from the group consisting of SEQ ID NO: 8 and SEQ ID NO: 19.
2. The method of claim 1 , wherein the cells do not express endogenous Dkk1.
3. The method of claim 1 , wherein the cells contacted with the Dkk1 protein migrate to the site of a wound.