Compounds for the treatment of inflammatory disorders
View Patent ↗This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.
1. A method of treating a condition or disease comprising: administering to a patient in need of such treatment a therapeutically effective amount of at least one compound or a pharmaceutically acceptable salt thereof, wherein the condition or disease is selected from the group consisting of septic shock, sepsis syndrome, post ischaemic reperfusion injury, meningitis, psoriasis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, inflammatory bowel disease, adults Still's disease, non-insulin dependent diabetes mellitus, asthma, and chronic obstructive pulmonary disease, and wherein the compound is selected from one of the following compounds:
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the condition or disease is rheumatoid arthritis.
3. The method of claim 1 , wherein the condition or disease is inflammatory bowel disease.
4. The method of claim 3 , wherein the inflammatory bowel disease is Crohn's disease.
5. The method of claim 3 , wherein the inflammatory bowel disease is colitis.
6. The method of claim 1 , wherein the condition or disease is chronic obstructive pulmonary disorder.
7. The method of claim 1 , wherein the condition or disease is psoriasis.
8. The method of claim 1 , wherein the condition or disease is ankylosing spondylitis.
9. The method of claim 1 , wherein the condition or disease is psoriatic arthritis.