METHODS FOR TREATMENT OF INTESTINAL CARCINOGENESIS WITH RICE BRAN
The present invention provides a method for treating colorectal cancer and reducing adenoma development in mammals by administering rice bran.
1 . A method for treating, reducing or preventing reoccurrence of adenoma development in a mammal, said method comprising:
administering rice bran to said mammal, thereby treating adenoma development.
2 . The method of claim 1 , wherein said mammal is a human being.
3 . The method of claim 2 , wherein the effective dose of rice bran is about 150 g to about 250 g pd per diem, per 70 kg body weight.
4 . The method of claim 1 , wherein said rice bran is stabilized rice bran.
5 . The method of claim 1 , wherein adenoma development is retarded or reduced.
6 . The method of claim 1 , wherein said rice bran exerts a physical effect, hastening fecal transit in said mammal.
7 . The method of claim 1 , wherein said rice bran changes the gastrointestinal microflora and luminal environment to alter the bacterial species population of said mammal.
8 . The method of claim 1 , wherein said rice bran undergo fermentation in the luminal environment, generating short chain fatty acids such as butyrate, which exert an anticarcinogenic effect.
9 . The method of claim 1 , wherein said adenoma is an adenocarcinoma.
10 . The method of claim 1 , wherein said adenoma size and/or distribution development is retarded.
11 . A method for treating or reducing the incidence of colorectal cancer in a mammal, said method comprising:
administering rice bran to said mammal, thereby treating colorectal cancer.
12 . The method of claim 11 , wherein said mammal is a human being.
13 . The method of claim 12 , wherein the effective dose of rice bran is about 150 g to about 250 g per diem, per 70 kg body weight.
14 . The method of claim 11 , wherein said rice bran is stabilized rice bran.
15 . The method of claim 11 , wherein adenocarcinoma development is retarded or reduced.
16 . The method of claim 11 , wherein said rice bran exerts a physical effect, hastening fecal transit in said mammal.
17 . The method of claim 11 , wherein said rice bran changes the gastrointestinal microflora and luminal environment to alter the bacterial species population of said mammal.
18 . The method of claim 11 , wherein said rice bran undergo fermentation in the luminal environment, generating short chain fatty acids such as butyrate, which exert an anticarcinogenic effect.
19 . The method of claim 11 , wherein said adenoma size and/or distribution development is retarded.
20 . A method of chemopreventive intervention in a human with existing intestinal polyps, said method comprising:
administrating rice bran at a dose of about 150 g to about 250 g per diem, per 70 kg body weight, thereby preventing or reducing cancer in said human with existing intestinal polyps.