Morpholinyl and pyrrolidinyl analogs

1. A compound of Formula (I):

wherein

R 1 is:

A is (CH 2 ) n ;

n is 1 or 2;

the group (a) may be unsubstituted or substituted by one, two, or three substituents chosen from: halo, OC 1-3 alkyl, OH, CN, C(O)OH, NR 7 R 8 , OCF 3 , C(O)NR 9 R 10 , SO 2 C 1-3 alkyl, SO 2 C 3-6 cycloalkyl, SO 2 -phenyl, SO 2 NR 9 R 10 , CF 3 , and NO 2 ;

R 2 is hydrogen, halo, OC 1-3 alkyl, NHC(O)C 1-3 alkyl, NHSO 2 C 1-3 alkyl, NHSO 2 -phenyl, NHC(O)C 3-6 cycloalkyl, or NHC(O)-phenyl;

R 3 is C 1-3 alkyl or C 3-6 cycloalkyl;

R 4 , R 5 , and R 6 are independently hydrogen or CH 3 ;

R 7 and R 8 are independently hydrogen, C(O)C 1-3 alkyl, C(O)C 3-6 cycloalkyl, C(O)-phenyl, C 1-6 alkyl, phenyl, SO 2 C 1-3 alkyl, SO 2 C 3-6 cycloalkyl, SO 2 -phenyl, or C(O)NHC 1-3 alkyl;

R 9 and R 10 are independently hydrogen, C 1-3 alkyl, C 3-6 cycloalkyl, phenyl;

or taken together R 9 and R 10 may form a 5 to 7 member ring optionally containing one or two heteroatoms chosen from O, N, and S;

X is O or a bond;

B is:

R 14 is hydrogen, halo, C 1-3 alkyl, OC 1-3 alkyl, OCF 3 , CF 3 , C(O)NR 15 R 16 , or C(O)OC 1-3 alkyl; and

R 15 and R 16 are independently hydrogen, C 1-3 alkyl, C 3-6 cycloalkyl, or phenyl;

or a pharmaceutically acceptable salt thereof.

2. A compound of claim 1 wherein:

R 1 is phenyl substituted by one or two halo, OC 1-3 alkyl, CN, C(O)OH, NR 7 R 8 , C(O)NR 9 R 10 , SO 2 C 1-3 alkyl, or SO 2 NR 11 R 12 ;

R 2 is hydrogen or halo;

R 3 is methyl;

R 4 is hydrogen or CH 3 ;

R 5 and R 6 are hydrogen;

R 7 and R 8 are independently hydrogen, C(O)C 1-3 alkyl, C 1-6 alkyl, SO 2 C 1-3 alkyl, or C(O)NHC 1-3 alkyl;

R 9 and R 10 are independently H, C 1-3 alkyl;

or taken together R 9 and R 10 form a pyrrolidine, morpholine, or piperidine group;

X is O or a bond;

B is:

R 14 is hydrogen or halo;

or a pharmaceutically acceptable salt thereof.

3. A compound of claim 1 wherein:

R 1 is phenyl substituted by one or two OC 1-3 alkyl, C(O)OH, or C(O)NR 9 R 10 ;

R 2 is hydrogen or halo;

R 3 is methyl;

R 4 is hydrogen or CH 3 ;

R 5 and R 6 are hydrogen;

R 9 and R 10 are independently hydrogen, C 1-3 alkyl;

or taken together R 9 and R 10 form a pyrrolidine, morpholine, or piperidine group;

X is O or a bond;

B is:

R 14 is hydrogen or halo;

or a pharmaceutically acceptable salt thereof.

4. A compound of claim 1 selected from:

N-[1-(4-biphenyl)-1)-2-(1-pyrrolidinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

N-(1-biphenyl-4-yl-2-pyrrolidin-1-ylethyl)-2-(6,7-dibromo-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

N-[1-(4-biphenylyl)-2-(1-pyrrolidinyl)ethyl]-2-(6,7-dimethyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

(N-[1-(4-biphenylyl)-2-(4-morpholinyl)ethyl]-2-(6,7-dibromo-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

N-[1-(4-biphenylyl)-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

N-[1-[3′,4′-bis(methyloxy)-4-biphenylyl]-2-(1-pyrrolidinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

4′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(1-pyrrolidinyl)ethyl]-4-biphenylcarboxylic acid;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-{3′-[(1-methylethyl)oxy]-4-biphenylyl}-2-(1-pyrrolidinyl)ethyl]acetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-{3′-[(methylsulfonyl)amino]-4-biphenylyl}-2-(1-pyrrolidinyl)ethyl]acetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-[1-[4′-(dimethylamino)-4-biphenylyl]-2-(1-pyrrolidinyl)ethyl]-N-methylacetamide;

N-[1-[4′-(acetylamino)-4-biphenylyl]-2-(1-pyrrolidinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-[3′-(methyloxy)-4-biphenylyl]-2-(1-pyrrolidinyl)ethyl]acetamide;

4′-[1-[[(6,7-dimethyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(1-pyrrolidinyl)ethyl]-4-biphenylcarboxylic acid;

2-(6,7-dimethyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-{3′-[(1-methylethyl)oxy]-4-biphenylyl}-2-(1-pyrrolidinyl)ethyl]acetamide;

2-(6,7-dimethyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-{3′-[(methylsulfonyl)amino]-4-biphenylyl}-2-(1-pyrrolidinyl)ethyl]acetamide;

N-[1-[4′-(dimethylamino)-4-biphenylyl]-2-(1-pyrrolidinyl)ethyl]-2-(6,7-dimethyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

N-[1-[4′-(acetylamino)-4-biphenylyl]-2-(1-pyrrolidinyl)ethyl]-2-(6,7-dimethyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

2-(6,7-dimethyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-[3′-(methyloxy)-4-biphenylyl]-2-(1-pyrrolidinyl)ethyl]acetamide;

N-[1-[3′,4′-bis(methyloxy)-4-biphenylyl]-2-(1-pyrrolidinyl)ethyl]-2-(6,7-dimethyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

N-[1-(4′-chloro-3-biphenylyl)-2-(1-pyrrolidinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-[1-[4′-(dimethylamino)-3-biphenylyl]-2-(1-pyrrolidinyl)ethyl]-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-[3′-(methyloxy)-3-biphenylyl]-2-(1-pyrrolidinyl)ethyl]acetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-[1-(2′-hydroxy-3-biphenylyl)-2-(1-pyrrolidinyl)ethyl]-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-[1-(4′-hydroxy-3-biphenylyl)-2-(1-pyrrolidinyl)ethyl]-N-methylacetamide;

N-[1-[4′-(acetylamino)-3-biphenylyl]-2-(1-pyrrolidinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-{4′-[(methylsulfonyl)amino]-4-biphenylyl}-2-(4-morpholinyl)ethyl]acetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-{4′-(methylsulfonyl)-4-biphenylyl}-2-(4-morpholinyl)ethyl]acetamide;

N-{1-[3′-(acetylamino)biphenyl-4-yl]-2-morpholin-4-ylethyl}-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-{2′-[(methylsulfonyl)amino]-4-biphenylyl}-2-(4-morpholinyl)ethyl]acetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-[1-[4′-(ethylsulfonyl)-4-biphenylyl]-2-(4-morpholinyl)ethyl]-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-{2-(4-morpholinyl)-1-[3′-(1-piperidinylcarbonyl)-4-biphenylyl]ethyl}acetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-{2-(4-morpholinyl)-1-[4′-(4-morpholinylcarbonyl)-4-biphenylyl]ethyl}acetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-{2-(4-morpholinyl)-1-[3′-(4-morpholinylcarbonyl)-4-biphenylyl]ethyl}acetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-[1-[3′-(ethyloxy)-4-biphenylyl]-2-(4-morpholinyl)ethyl]-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-[1-[5′-(ethyloxy)-2′-fluoro-4-biphenylyl]-2-(4-morpholinyl)ethyl]-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-[1-[4′-(dimethylamino)-4-biphenylyl]-2-(4-morpholinyl)ethyl]-N-methylacetamide;

N-[1-[2′,3′-bis(methyloxy)-4-biphenylyl]-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

4′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-3-biphenylcarboxamide;

4′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-N-methyl-3-biphenylcarboxamide;

4′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-N,N-dimethyl-3-biphenylcarboxamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-{3′-[(methylsulfonyl)amino]-4-biphenylyl}-2-(4-morpholinyl)ethyl]acetamide;

4′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-2-biphenylcarboxamide;

4′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-4-biphenylcarboxamide;

4′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-N-methyl-4-biphenylcarboxamide;

4′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-N,N-dimethyl-4-biphenylcarboxamide;

N-cyclopropyl-4′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl] (methyl)amino]-2-(4-morpholinyl)ethyl]-3-biphenylcarboxamide;

4′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl] (methyl)amino]-2-(4-morpholinyl)ethyl]-N-(1-methylethyl)-3-biphenylcarboxamide;

4′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl] (methyl)amino]-2-(4-morpholinyl)ethyl]-5-fluoro-N-methyl-3-biphenylcarboxamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-{2-(4-morpholinyl)-1-[3′-(1-pyrrolidinylcarbonyl)-4-biphenylyl]ethyl}acetamide;

N-[1-[2′-(acetylamino)-4-biphenylyl]-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-{4′-[(methylamino)sulfonyl]-4-biphenylyl}-2-(4-morpholinyl)ethyl]acetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-[1-{4′-[(dimethylamino)sulfonyl]-4-biphenylyl}-2-(4-morpholinyl)ethyl]-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-[1-{2′-[(dimethylamino)sulfonyl]-4-biphenylyl}-2-(4-morpholinyl)ethyl]-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-{2-(4-morpholinyl)-1-[3′-(1-piperidinylcarbonyl)-3-biphenylyl]ethyl}acetamide;

N-[1-[3′,4′-bis(methyloxy)-3-biphenylyl]-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-{4′-[(methylsulfonyl)amino]-3-biphenylyl}-2-(4-morpholinyl)ethyl]acetamide;

N-[1-[4′-(acetylamino)-3-biphenylyl]-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-[4′-(methylsulfonyl)-3-biphenylyl]-2-(4-morpholinyl)ethyl]acetamide;

N-[1-[4′-(acetylamino)-3-biphenylyl]-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

3′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl] (methyl)amino]-2-(4-morpholinyl)ethyl]-3-biphenylcarboxamide;

N-[1-[2′-(acetylamino)-3-biphenylyl]-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

N-[1-(4′-cyano-3-biphenylyl)-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-{3′-[(methylsulfonyl)amino]-3-biphenylyl}-2-(4-morpholinyl)ethyl]acetamide;

3′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-2-biphenylcarboxamide;

N-[1-(2′-cyano-3-biphenylyl)-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-[1-[4′-(ethylsulfonyl)-3-biphenylyl]-2-(4-morpholinyl)ethyl]-N-methylacetamide;

3′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-N-methyl-4-biphenylcarboxamide;

3′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-N,N-dimethyl-4-biphenylcarboxamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-{2′-[(methylsulfonyl)amino]-3-biphenylyl}-2-(4-morpholinyl)ethyl]acetamide;

N-[1-[4′-(aminosulfonyl)-3-biphenylyl]-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

3′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-4-biphenylcarboxamide;

3′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-N,N-dimethyl-3-biphenylcarboxamide;

3′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-N-methyl-3-biphenylcarboxamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-{2-(4-morpholinyl)-1-[4′-(1-pyrrolidinylcarbonyl)-3-biphenylyl]ethyl}acetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-{2-(4-morpholinyl)-1-[4′-(4-morpholinylcarbonyl)-3-biphenylyl]ethyl}acetamide; 2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-[1-[3′-(dimethylamino)-3-biphenylyl]-2-(4-morpholinyl)ethyl]-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-[1-{2′-[(dimethylamino)sulfonyl]-3-biphenylyl}-2-(4-morpholinyl)ethyl]-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-{2-(4-morpholinyl)-1-[3′-(1-pyrrolidinylcarbonyl)-3-biphenylyl]ethyl}acetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-{2-(4-morpholinyl)-1-[4′-(1-piperidinylcarbonyl)-3-biphenylyl]ethyl}acetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-[3′-(methylsulfonyl)-3-biphenylyl]-2-(4-morpholinyl)ethyl]acetamide;

3-chloro-3′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-4-biphenylcarboxamide;

N-cyclopropyl-3′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-4-biphenylcarboxamide;

3′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl] (methyl)amino]-2-(4-morpholinyl)ethyl]-N-(1-methylethyl)-3-biphenylcarboxamide;

3′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-4-biphenylcarboxylic acid;

2-(6,7-dimethyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-{3′-[(1-methylethyl)oxy]-4-biphenylyl}-2-(4-morpholinyl)ethyl]acetamide;

2-(6,7-dimethyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-{3′-[(methylsulfonyl)amino]-4-biphenylyl}-2-(4-morpholinyl)ethyl]acetamide;

N-[1-[3′,4′-bis(methyloxy)-4-biphenylyl]-2-(4-morpholinyl)ethyl]-2-(6,7-dimethyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-[3′-(methyloxy)-4-biphenylyl]-2-(4-morpholinyl)ethyl]acetamide;

N-[1-[3′,4′-bis(methyloxy)-4-biphenylyl]-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

4′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-4-biphenylcarboxylic acid;

N-[1-[4′-(acetylamino)-4-biphenylyl]-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

N-[1-(4′-amino-4-biphenylyl)-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

N-{4′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-4-biphenylyl}propanamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-[1-{4′-[(ethylsulfonyl)amino]-4-biphenylyl}-2-(4-morpholinyl)ethyl]-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-[1-(4′-{[(ethylamino)carbonyl]amino}-4-biphenylyl)-2-(4-morpholinyl)ethyl]-N-methylacetamide;

N-[1-(4-biphenylyl)-2-(1-pyrrolidinyl)ethyl]-N-methyl-2-[7-(methyloxy)-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetamide;

(R) N-[1-(4-biphenylyl)-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

N-[1-(4-biphenylyl)-2-(1-pyrrolidinyl)ethyl]-N-methyl-2-[6-(methyloxy)-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetamide; and

N-[1-(4-biphenylyl)-2-(1-pyrrolidinyl)ethyl]-N-methyl-2-{3-oxo-6-[(trifluoromethyl)oxy]-2,3-dihydro-4H-1,4-benzoxazin-4-yl}acetamide;

or a pharmaceutically acceptable salt thereof.

5. A compound of claim 1 selected from:

N-[1-(4-biphenylyl)-2-(4-morpholinyl)ethyl]-2-(6,7-dimethyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

3-chloro-4′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-N-methyl-4-biphenylcarboxamide;

3-chloro-4′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-N,N-dimethyl-4-biphenylcarboxamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-{2-(4-morpholinyl)-1-[2′-(trifluoromethyl)-4-biphenylyl]ethyl}acetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-{2-(4-morpholinyl)-1-[3′-(trifluoromethyl)-4-biphenylyl]ethyl}acetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-{2-(4-morpholinyl)-1-[4′-(trifluoromethyl)-4-biphenylyl]ethyl}acetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-[1-(2′-fluoro-4-biphenylyl)-2-(4-morpholinyl)ethyl]-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-[1-(3′-fluoro-4-biphenylyl)-2-(4-morpholinyl)ethyl]-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-[1-(4′-fluoro-4-biphenylyl)-2-(4-morpholinyl)ethyl]-N-methylacetamide;

N-[1-(4-biphenylyl)-2-(4-morpholinyl)ethyl]-2-(6,7-dimethyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

N-[1-(3′-cyano-4-biphenylyl)-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

N-cyclopropyl-4′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-4-biphenylcarboxamide;

4′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-N-(1-methylethyl)-4-biphenylcarboxamide;

3-chloro-4′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-4-biphenylcarboxamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-{2-(4-morpholinyl)-1-[4′-(1-piperidinylcarbonyl)-4-biphenylyl]ethyl}acetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-[4-(4-methyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl)phenyl]-2-(4-morpholinyl)ethyl]acetamide;

N-[1-[4′-(aminosulfonyl)-4-biphenylyl]-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

N-[1-(3′-cyano-3-biphenylyl)-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

N-[1-(3-biphenylyl)-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-[1-{4′-[(dimethylamino)sulfonyl]-3-biphenylyl}-2-(4-morpholinyl)ethyl]-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-[1-[4′-(dimethylamino)-3-biphenylyl]-2-(4-morpholinyl)ethyl]-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-{2-(4-morpholinyl)-1-[3′-(1-piperidinylcarbonyl)-3-biphenylyl]ethyl}acetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[2-(4-morpholinyl)-1-(3′-nitro-3-biphenylyl)ethyl]acetamide;

N-[1-(4-biphenylyl)-2-(4-morpholinyl)ethyl]-2-(6,7-dimethyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

N-[1-[4′-(dimethylamino)-4-biphenylyl]-2-(4-morpholinyl)ethyl]-2-(6,7-dimethyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-{3′-[(1-methylethyl)oxy]-4-biphenylyl}-2-(4-morpholinyl)ethyl]acetamide;

1,1-dimethylethyl {4′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-4-biphenylyl}carbamate;

[N-[1-(4-biphenylyl)-2-(1-pyrrolidinyl)ethyl]-N-methyl-2-[7-methyl-6-(methyloxy)-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetamide;

N-[1-(4-biphenylyl)-2-(4-morpholinyl)ethyl]-N-methyl-2-[7-methyl-6-(methyloxy)-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetamide;

N-[1-(4-biphenylyl)-1-methyl-2-(1-pyrrolidinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

(S) N-[1-(4-biphenylyl)-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

Ethyl 4-{2-[[1-(4-biphenylyl)-2-(1-pyrrolidinyl)ethyl](methyl)amino]-2-oxoethyl}-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate;

Ethyl 4-{2-[[1-(4-biphenylyl)-2-(4-morpholinyl)ethyl](methyl)amino]-2-oxoethyl}-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate;

4-{2-[[1-(4-biphenylyl)-2-(1-pyrrolidinyl)ethyl] (methyl)amino]-2-oxoethyl}-N-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide;

4-{2-[[1-(4-biphenylyl)-2-(1-pyrrolidinyl)ethyl] (methyl)amino]-2-oxoethyl}-N,N-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide;

4-{2-[[1-(4-biphenylyl)-2-(1-pyrrolidinyl)ethyl] (methyl)amino]-2-oxoethyl}-N-ethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide;

4-{2-[[1-(4-biphenylyl)-2-(1-pyrrolidinyl)ethyl] (methyl)amino]-2-oxoethyl}-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide;

4-{2-[[1-(4-biphenylyl)-2-(4-morpholinyl)ethyl] (methyl)amino]-2-oxoethyl}-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide;

2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-[1-(3-fluoro-4-biphenylyl)-2-(4-morpholinyl)ethyl]-N-methylacetamide;

N-[1-(3-chloro-4-biphenylyl)-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide;

N-[1-(4-biphenylyl)-2-(4-morpholinyl)ethyl]-N-methyl-2-{3-oxo-6-[(trifluoromethyl)oxy]-2,3-dihydro-4H-1,4-benzoxazin-4-yl}acetamide; and

N-[1-(4-biphenylyl)-2-(1-pyrrolidinyl)ethyl]-N-methyl-2-[7-(methyloxy)-3-oxo-6-(trifluoromethyl)-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetamide; and

or a pharmaceutically acceptable salt thereof.

6. A compound of claim 1 selected from:

4′-[(1R)-1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl] (methyl)amino]-2-(1-pyrrolidinyl)ethyl]-3-biphenylcarboxamide; and

4′-[(1R)-1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl] (methyl)amino]-2-(1-pyrrolidinyl)ethyl]-4-biphenylcarboxamide;

or a pharmaceutically acceptable salt thereof.

7. A compound of claim 1 which is 4′-[(1R)-1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(1-pyrrolidinyl)ethyl]-3-biphenylcarboxamide Trifluoroacetate salt.

8. A pharmaceutical composition comprising a compound of formula (I) claim 1 and a pharmaceutically acceptable carrier or excipient.

9. A method of treating congestive heart failure, stroke, ischemic heart disease, angina, myocardial ischemia, overactive bladder, or cardiac arrhythmia which comprises administering to a patient in need thereof, a compound of Formula I of claim 1 .

10. A method of treating hypertension which comprises administering to a patient in need thereof, a compound of Formula I of claim 1 .