Adjuvant for vaccines
Vaccine containing a first vaccine, adjuvated with an oil-in-water emulsion comprising 5% squalene, 0.5% polysorbate 80 and 0.5% sorbitan trioleate in aqueous citrate buffer pH 6.5, and a nonadjuvated second vaccine as combination partners for the simultaneous, separate or phased application for immunization against viral, bacterial or parasitic infectious diseases.
1 . A method for the contralateral administration of more than one vaccine composition, said method comprising:
(1) administering a first vaccine composition comprising a selected antigen and MF59 to a subject; and
(2) administering a second vaccine composition contralaterally to the subject, wherein said second vaccine composition comprises a selected antigen and does not include MF59.
2 . The method of claim 1 , wherein the antigen in said first vaccine composition and said second vaccine composition is a viral, bacterial or parasitic antigen.
3 . The method of claim 1 , wherein said second vaccine composition is administered substantially simultaneously with said first vaccine composition.
4 . The method of claim 1 , wherein said first vaccine composition is an influenza protein subunit vaccine.
5 . The method of claim 1 , wherein said second vaccine composition is a pneumococcal capsule polysaccharide vaccine or a pneumococcal polysaccharide conjugate vaccine.
6 . The method of claim 1 , wherein said second vaccine further comprises an adjuvant that comprises an aluminum compound.
7 . The method of claim 6 , wherein said adjuvant is alum.
8 . The method of claim 1 , wherein said first vaccine composition and/or said second vaccine composition comprises a polynucleotide encoding the selected antigen.
9 . The method of claim 1 , wherein said first vaccine composition and/or said second vaccine composition is a whole-cell vaccine.
10 . The method of claim 1 , wherein said first vaccine composition and/or said second vaccine composition is a protein subunit vaccine.
11 . The method of claim 1 , wherein said first vaccine composition and/or said second vaccine composition is a polysaccharide vaccine.
12 . The method of claim 1 , wherein said first vaccine composition and/or said second vaccine composition is a polysaccharide conjugate vaccine.
13 . The method of claim 1 , wherein said second vaccine composition is a vaccine selected from the group consisting of rabies, diphtheria, tetanus, meningococcus, HIV, HBV, Helicobacter pylori , early summer meningoencephalitis and typhus.
14 . A method for the contralateral administration of more than one vaccine composition, said method comprising:
(1) administering a first vaccine composition comprising an influenza protein subunit and MF59 to a subject; and
(2) administering a second vaccine composition contralaterally to the subject, wherein said second vaccine composition comprises a selected antigen and does not include MF59.
15 . The method of claim 14 , wherein the antigen in said second vaccine composition is a viral, bacterial or parasitic antigen.
16 . The method of claim 14 , wherein said second vaccine composition is administered substantially simultaneously with said first vaccine composition.
17 . The method of claim 14 , wherein said second vaccine further comprises an adjuvant that comprises an aluminum compound.
18 . The method of claim 17 , wherein said adjuvant is alum.
19 . The method of claim 14 , wherein said second vaccine composition comprises a polynucleotide encoding the selected antigen.
20 . The method of claim 14 , wherein said second vaccine composition is a whole-cell vaccine.
21 . The method of claim 14 , wherein said second vaccine composition is a protein subunit vaccine.
22 . The method of claim 14 , wherein said second vaccine composition is a polysaccharide vaccine.
23 . The method of claim 14 , wherein said second vaccine composition is a polysaccharide conjugate vaccine.
24 . The method of claim 14 , wherein said second vaccine composition is a vaccine selected from the group consisting of rabies, diphtheria, tetanus, meningococcus, HIV, HBV, Helicobacter pylori , early summer meningoencephalitis and typhus.
25 . A method for immunizing against influenza and pneumococcus infections, said method comprising:
(1) administering a first vaccine composition comprising an influenza protein subunit and MF59 to a subject; and
(2) administering a second vaccine composition contralaterally to the subject, wherein said second vaccine composition is a pneumococcal capsule polysaccharide vaccine or a pneumococcal polysaccharide conjugate and does not include MF59.
26 . The method of claim 25 , wherein said second vaccine composition is a pneumococcal capsule polysaccharide vaccine.
27 . The method of claim 25 , wherein said second vaccine composition is a pneumococcal polysaccharide conjugate vaccine.
28 . The method of claim 25 , wherein said second vaccine composition is administered substantially simultaneously with said first vaccine composition.
29 . The method of claim 25 , wherein said second vaccine further comprises an adjuvant that comprises an aluminum compound.
30 . The method of claim 29 , wherein said adjuvant is alum.